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Massive TB vaccine trial could save millions

NCT ID NCT06062238

Ongoing ⭐️ VACCINE ⭐️ Sponsor: Gates Medical Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This large study tests an experimental vaccine called M72/AS01E-4 to see if it can prevent tuberculosis (TB) in teens and adults. About 20,000 people will receive either the vaccine or a placebo. The goal is to find a safe and effective way to stop TB, a serious lung infection.

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Conditions

The condition(s) this trial relates to.

tuberculosis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TUBERCULOSIS

Contacts and locations

Locations

  • 1001-Gates MRI Investigational Site

    Paarl, 7626, South Africa

  • 1002-Gates MRI Investigational Site

    Mtubatuba, 3935, South Africa

  • 1003-Gates MRI Investigational Site

    Cape Town, 7700, South Africa

  • 1004-Gates MRI Investigational Site

    Middelburg, 1050, South Africa

  • 1005-Gates MRI Investigational Site

    Pretoria, 0152, South Africa

  • 1006-Gates MRI Investigational Site

    Cape Town, 7530, South Africa

  • 1007-Gates MRI Investigational Site

    Johannesburg, 2193, South Africa

  • 1008-Gates MRI Investigational Site

    Cape Town, 7925, South Africa

  • 1009-Gates MRI Investigational Site

    Durban, 3610, South Africa

  • 1010-Gates MRI Investigational Site

    East London, 5201, South Africa

  • 1011-Gates MRI Investigational Site

    Soweto, 1818, South Africa

  • 1012-Gates MRI Investigational Site

    Ladysmith, 3370, South Africa

  • 1013-Gates MRI Investigational Site

    Port Elizabeth, 6001, South Africa

  • 1014-Gates MRI Investigational Site

    Jouberton, 2574, South Africa

  • 1015-Gates MRI Investigational Site

    Soweto, 2013, South Africa

  • 1016-Gates MRI Investigational Site

    Brits, 0250, South Africa

  • 1017-Gates MRI Investigational Site

    Klerksdorp, 2570, South Africa

  • 1018-Gates MRI Investigational Site

    Johannesburg, 1864, South Africa

  • 1019-Gates MRI Investigational Site

    Rustenburg, 0299, South Africa

  • 1020-Gates MRI Investigational Site

    Johannesburg, 2001, South Africa

  • 1021-Gates MRI Investigational Site

    Cape Town, 7405, South Africa

  • 1022-Gates MRI Investigational Site

    Cape Town, 7784, South Africa

  • 1023-Gates MRI Investigational Site

    Worcester, 6850, South Africa

  • 1024-Gates MRI Investigational Site

    Cape Town, 7505, South Africa

  • 1025-Gates MRI Investigational Site

    Tembisa, 1632, South Africa

  • 1026-Gates MRI Investigational Site

    Durban, 4068, South Africa

  • 1027-Gates MRI Investigational Site

    Kimberley, 8301, South Africa

  • 1028-Gates MRI Investigational Site

    Johannesburg, 1401, South Africa

  • 1029-Gates MRI Investigational Site

    Durban, 4091, South Africa

  • 1030-Gates MRI Investigational Site

    Vereeniging, 1935, South Africa

  • 1031-Gates MRI Investigational Site

    Johannesburg, 1811, South Africa

  • 1032-Gates MRI Investigational Site #1

    Tembisa, 1632, South Africa

  • 1033-Gates MRI Investigational Site

    Bloemfontein, 9301, South Africa

  • 1034-Gates MRI Investigational Site

    Cape Town, 7750, South Africa

  • 1201-Gates MRI Investigational Site

    Nairobi, 00202, Kenya

  • 1202-Gates MRI Investigational Site

    Kisumu, 40100, Kenya

  • 1203-Gates MRI Investigational Site

    Homa Bay, 40300, Kenya

  • 1204-Gates MRI Investigational Site

    Mombasa, 80103, Kenya

  • 1205-Gates MRI Investigational Site

    Eldoret, 30100, Kenya

  • 1206-Gates MRI Investigational Site

    Kericho, 20200, Kenya

  • 1207-Gates MRI Investigational Site

    Kilifi, 80108, Kenya

  • 1208-Gates MRI Investigational Site

    Machakos, 90100, Kenya

  • 1209-Gates MRI Investigational Site

    Nairobi, 00100, Kenya

  • 1301-Gates MRI Investigational Site

    Lusaka, 50697, Zambia

  • 1302-Gates MRI Investigational Site

    Lusaka, 10101, Zambia

  • 1303-Gates MRI Investigational Site

    Lusaka, 412, Zambia

  • 1304-Gates MRI Investigational Site

    Ndola, 240262, Zambia

  • 2201-Gates MRI Investigational Site

    Bandung, 40161, Indonesia

  • 2202-Gates MRI Investigational Site

    Jakarta, 10430, Indonesia

  • 2203-Gates MRI Investigational Site

    Jakarta, 13230, Indonesia

  • 2204-Gates MRI Investigational Site

    Depok, 16424, Indonesia

  • 2205-Gates MRI Investigational Site

    Jakarta, 10510, Indonesia

  • 2401-Gates MRI Investigational Site

    Lilongwe, 0149, Malawi

  • 2402-Gates MRI Investigational Site

    Chichiri, 30096, Malawi

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