ER shock showdown: less fluid, early pressors vs. standard care
NCT ID NCT04569942
First seen Nov 21, 2025 · Last updated Jun 23, 2026 · Updated 29 times
Summary
This study tests two strategies for treating septic shock in the emergency department. One group gets less IV fluid and starts blood-pressure-raising drugs (vasopressors) early. The other group gets more IV fluid first, then vasopressors if needed. The trial includes 1000 patients across Australia and New Zealand and tracks how many days they are alive and out of the hospital up to 90 days later.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Alfred Hospital
Melbourne, Victoria, 3004, Australia
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Angliss Hospital
Ferntree Gully, Victoria, 3156, Australia
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Auckland City Hospital
Auckland, North Island, 1023, New Zealand
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Ballarat Base Hospital
Ballarat, Victoria, 3353, Australia
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Bankstown Hospital
Bankstown, New South Wales, 2200, Australia
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Barwon Health Geelong Hospital
Geelong, Victoria, 3220, Australia
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Bendigo Hospital
Bendigo, Victoria, 3550, Australia
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Box Hill Hospital
Box Hill, Victoria, 3128, Australia
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Bunbury Hospital
Bunbury, Western Australia, 6230, Australia
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Bundaberg Hospital
Bundaberg, Queensland, 4670, Australia
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Caboolture Hospital
Caboolture, Queensland, 4510, Australia
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Cairns Hospital
Cairns, Queensland, 4870, Australia
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Casey Hospital
Berwick, Victoria, 3806, Australia
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Dandenong Hospital
Dandenong, Victoria, Australia
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Dunedin Hospital
Dunedin, Otago, 9054, New Zealand
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Fiona Stanley Hospital
Perth, Western Australia, 6150, Australia
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Flinders Medical Centre
Streaky Bay, South Australia, 5025, Australia
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Gold Coast University Hospital
Southport, Queensland, 4215, Australia
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Hervey Bay Hospital
Hervey Bay, Queensland, 4655, Australia
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Ipswich Hospital
Ipswich, Queensland, 4305, Australia
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John Hunter Hospital
New Lambton Heights, New South Wales, 2305, Australia
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Mackay Base Hospital
Mackay, Queensland, 4740, Australia
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Maroondah Hospital
Ringwood East, Victoria, 3135, Australia
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Middlemore Hospital
Middlemore, Otahuhu, 1640, New Zealand
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Monash Medical Centre
Clayton, Victoria, 3168, Australia
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Nepean Hosital
Kingswood, New South Wales, 2747, Australia
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Northern Hospital
Epping, Victoria, 3076, Australia
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Port Macquarie Base Hospital
Port Macquarie, New South Wales, 2444, Australia
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QE II Jubilee Hospital
Brisbane, Queensland, 4108, Australia
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Robina Hospital
Robina, Queensland, 4226, Australia
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Royal Darwin & Palmerston Hospital
Darwin, Northern Territory, 0811, Australia
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Royal Melbourne Hospital
Parkville, Victoria, 3050, Australia
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Royal North Shore Hosptial
Sydney, New South Wales, 2065, Australia
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Royal Perth Hospital
Perth, Western Australia, 6000, Australia
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Royal Prince Alfred Hospital
Camperdown, New South Wales, 2050, Australia
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Ryde Hospital
Sydney, New South Wales, 2112, Australia
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St John of God Hospital
Midland, Western Australia, 6056, Australia
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St John of God Murdoch Hospital
Murdoch, Western Australia, 6150, Australia
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St. Vincent's Hospital
Fitzroy, Victoria, 3065, Australia
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St. Vincent's University Hospital
Elm Park, Dublin, D04 T6F4, Ireland
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Sunshine Coast university hospital
Sunshine Coast, Queensland, 4560, Australia
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Tamworth Hospital
Tamworth, New South Wales, 2340, Australia
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Taranki Hospital
Hawera, 4640, New Zealand
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The Prince Charles Hospital
Brisbane, Queensland, 4032, Australia
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The Queen Elizabeth Hospital
Adelaide, South Australia, 5011, Australia
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Toowoomba Hospital
Toowoomba, Queensland, 4350, Australia
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Townsville Hospital
Townsville, Queensland, 4810, Australia
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Wangaratta Hospital
Wangaratta, Victoria, 3677, Australia
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Wellington Hospital
Wellington, 2820, New Zealand
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Westmead Hospital
Westmead, New South Wales, 2145, Australia
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Vasopressors (e.g., noradrenaline) and IV fluids
What this could lead to
If it works, this could show that using vasopressors early with less fluid is a better way to treat septic shock, potentially improving survival and recovery.
What could go wrong
This is a large phase 3 trial, but results may not apply to all sepsis patients. The best approach may depend on individual patient factors, and there are risks from both too little fluid and from vasopressors.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.