Cheap drug could tame Leprosy's painful Flare-Ups
NCT ID NCT03775460
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tests whether adding methotrexate to standard steroid treatment can help people with a painful leprosy complication called ENL. 550 adults with active ENL will receive either methotrexate or a placebo alongside prednisolone. The goal is to see if methotrexate reduces the need for extra steroids over 48 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
methotrexate
What this could lead to
If it works, this could provide a cheap, widely available treatment to control ENL flares and reduce reliance on steroids.
What could go wrong
This is a large trial, but methotrexate may not reduce steroid needs as hoped. Side effects of methotrexate include liver and lung issues.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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ALERT
Addis Ababa, Ethiopia
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Anandaban Hospital
Kathmandu, Nepal
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Bombay Leprosy Project
Mumbai, India
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FIOCRUZ
Rio de Janeiro, Brazil
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Soetomo Hospital
Surabaya, Indonesia
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TMLI Bangladesh/ DBLM hospital
Dhaka, Bangladesh
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The Leprosy Mission Trust
Delhi, India