New antibody drug aims to calm painful skin condition

NCT ID NCT06993610

Ongoing Disease control Sponsor: Zura Bio Inc Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 2 times

Summary

This Phase 2 trial tests tibulizumab, a dual-action antibody, in 225 adults with hidradenitis suppurativa (HS), a chronic skin condition causing painful abscesses. Participants first receive either the drug or a placebo for 16 weeks, then everyone gets the drug for another 16 weeks. The goal is to see if tibulizumab reduces the number of abscesses and inflammatory nodules.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

tibulizumab (an antibody that targets BAFF and IL-17 to reduce inflammation)

What this could lead to

If successful, this could provide a new treatment option for hidradenitis suppurativa, potentially reducing painful flare-ups and improving quality of life.

What could go wrong

This is an early Phase 2 trial with only 225 participants, so results may not apply to everyone. The drug may cause side effects or fail to show significant benefit over placebo.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Acne Vulgaris dermatitis hidradenitis hidradenitis suppurativa skin disease caused by bacterial infection skin disorder sweat gland disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIDRADENITIS SUPPURATIVA (HS)

Contacts and locations

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Locations

Apex Clinical Research Center

Mayfield Heights, Ohio, 44124, United States
BRCR Global Texas

Katy, Texas, 77450, United States
Best Skin Research LLC

Camp Hill, Pennsylvania, 17011, United States
Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
Centre de recherche Saint-Louis

Québec, Quebec, G1W 4R4, Canada
Centrum Badawcze Panaceum Agnieszka Brzezicka, Magdalena Lenkiewicz Sp z .o.o

Malbork, 82200, Poland
ClinOhio Research Services

Columbus, Ohio, 43213, United States
Clinical Trials Management, LLC

Metairie, Louisiana, 70006, United States
DS Research of Kentucky, LLC

Louisville, Kentucky, 40241, United States
DelRicht LLC

Baton Rouge, Louisiana, 70809, United States
DelRicht Research

Mt. Pleasant, South Carolina, 29464, United States
DelRicht Research

Prosper, Texas, 75078, United States
Dermatology Specialists of Spokane

Spokane, Washington, 99202, United States
Dermatology Treatment and Research Center

Dallas, Texas, 75230, United States
Edificio IMIBIC, Reina Sofia University Hospital

Córdoba, 14004, Spain
Equity Medical

New York, New York, 10023, United States
Equity Medical LLC (Kentucky)

Bowling Green, Kentucky, 42104, United States
Fachklinik Bad Bentheim

Bad Bentheim, 48455, Germany
First OC Dermatology Research, Inc.

Irvine, California, 92614, United States
Florida Academic Dermatology Center

Coral Gables, Florida, 33134, United States
Frontier Dermatology

Mill Creek, Washington, 98012, United States
Georgia Skin & Cancer Clinic

Savannah, Georgia, 31419, United States
Gregorio Marañón General University Hospital

Madrid, 28007, Spain
Hospital Universitario La Paz

Madrid, 28046, Spain
Hospital Universitario Miguel Servet

Zaragoza, 50009, Spain
Indiana University School of Medicine

Indianapolis, Indiana, 46202, United States
International Clinical Research - Tennessee LLC

Murfreesboro, Tennessee, 37130, United States
Katholische Klinikum Bochum gGmbH

Bochum, 44791, Germany
Klinik und Poliklinik für Dermatologie und Allergologie

München, 80337, Germany
Klinikum Darmstadt

Darmstadt, 64283, Germany
Laser Clinic S.C.

Szczecin, 70-332, Poland
Manufaktura Zdrowia i Urody

Warsaw, 02-922, Poland
MediSearch Clinical Trials

Saint Joseph, Missouri, 64506, United States
Medical Dermatology Specialists (Phoenix)

Phoenix, Arizona, 85006, United States
NorCal Clinical Research

Rocklin, California, 95765, United States
North York Research Inc

North York, Ontario, M2J 5B2, Canada
Northridge Clinical Trials

Northridge, California, 91325, United States
OptiSkin Medical

New York, New York, 10128, United States
Optima Research

Boardman, Ohio, 44512, United States
Palmetto Clinical Trial Services

Anderson, South Carolina, 29625, United States
Progressive Clinical Research

San Antonio, Texas, 78213, United States
Provita Centrum Medyczne Sp. z o.o. Katowice

Katowice, 40-611, Poland
Provita Sp. z o. o.

Katowice, 40-611, Poland
RENEW Clinic

Bialystok, 15-797, Poland
Red River Research Partners

Fargo, North Dakota, 58103, United States
Ryan Clinical Research Inc.

Newmarket, Ontario, L3Y 5G8, Canada
SOLUMED

Poznan, 60-425, Poland
Saskatoon Dermatology Centre

Saskatoon, Saskatchewan, S7T 0G3, Canada
Semmelweis University

Budapest, 1085, Hungary
Skin Cancer and Dermatology Institute

Reno, Nevada, 89509, United States
Skin Care Research, LLC

Hollywood, Florida, 33021, United States
The Indiana Clinical Trials Center

Plainfield, Indiana, 46168, United States
University Clinic Dermatology Heidelberg

Heidelberg, 69120, Germany
University Hospital Dresden

Dresden, 01307, Germany
University Hospital Muenster - Münster

Münster, 48149, Germany
University of Debrecen

Debrecen, 4032, Hungary
University of Szeged

Szeged, 6720, Hungary
University of Washington Medical Center

Seattle, Washington, 98164, United States
Versorgungsforschung in der Dermatologie und bei Pflegeberufen (IVDP)

Hamburg, 20251, Germany
Wallace Medical Group, Inc.

Los Angeles, California, 90056, United States
York Dermatology Clinic & Research Centre

Richmond Hill, Ontario, L4B 1L1, Canada