Could vitamin B3 help beat TB? new trial launches
NCT ID NCT07517445
First seen Jun 24, 2026 · Last updated Aug 11, 2026 · Updated 6 times
Summary
This phase 2 trial tests whether adding nicotinamide (a form of vitamin B3) to a standard three-drug regimen can safely and effectively treat drug-susceptible pulmonary tuberculosis. About 165 adults with newly diagnosed TB will receive one of two doses of nicotinamide plus the standard drugs, or the standard drugs alone. The study measures how quickly the bacteria clear from sputum and monitors for side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- nicotinamide (vitamin B3) combined with bedaquiline, pretomanid, and linezolid
- What this could lead to
- If successful, this could lead to a shorter, more effective treatment regimen for drug-susceptible tuberculosis.
- What could go wrong
- This is an early phase 2 trial with only 165 participants, so results may not apply to everyone. The combination may cause side effects or not work better than existing treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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TASK Clinical Research Centre
Cape Town, Western Cape, 7530, South Africa
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The Aurum Institute Clinical Research Site - Pretoria
Pretoria, Gauteng, 87, South Africa
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UCT Lung Institute (Pty) Ltd (Centre for TB Research Innovation)
Cape Town, Western Cape, 7700, South Africa
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Wits RHI - Shandukani Research
Johannesburg, Gauteng, 2001, South Africa
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