Could a Double-Dose of antibiotics in bone cement prevent infections after hip surgery?
NCT ID NCT05164081
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two types of antibiotic-loaded bone cement used during hip fracture surgery to see which better prevents joint infections. About 7000 patients aged 60 and older with displaced femoral neck fractures will be included. Hospitals are randomly assigned to use either a single antibiotic (gentamicin) or a dual antibiotic (gentamicin plus clindamycin) cement for two years, then switch to the other for another two years. The main goal is to see if the dual-antibiotic cement reduces infection rates within one year after surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- antibiotic-loaded bone cement (gentamicin with or without clindamycin)
- What this could lead to
- If it works, this could point toward a better way to prevent serious joint infections after hip fracture surgery, potentially reducing reoperations and deaths.
- What could go wrong
- This is a large trial, but results may not apply to all patients or hospitals. Adding another antibiotic could also increase side effects or antibiotic resistance.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Umeå University Hospital
Umeå, Västerbotten County, Sweden
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