Can a tailored antibiotic regimen shorten endocarditis treatment without risk?

NCT ID NCT05144399

Ongoing Disease control Sponsor: Herlev Hospital Source: ClinicalTrials.gov ↗

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This trial investigates whether a shorter course of antibiotics, tailored to each patient's response, can treat left-sided endocarditis as safely as the standard 4-6 week regimen. Adults with endocarditis caused by specific bacteria (Streptococci, Enterococcus faecalis, or Staphylococcus aureus) receive an accelerated treatment plan based on their individual clinical data. The goal is to reduce hospital stays and associated risks while maintaining effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: accelerated antibiotic treatment tailored to individual response
What this could lead to: If successful, this could shorten hospital stays and reduce risks like mental strain and loss of function for patients with endocarditis, while saving healthcare costs.
What could go wrong: This is an early-stage trial testing a non-inferiority approach, so the shorter treatment might prove less effective or safe than standard care. Results are not yet available.

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Conditions

The condition(s) this trial relates to.

bacterial endocarditis endocarditis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOCARDITIS

Contacts and locations

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Locations

Bispebjerg Hospital

Copenhagen, Denmark
Brigham and Womens Hospital

Boston, Massachusetts, 02115, United States
Gødstrup Regional Hospital

Gødstrup, Denmark
Herlev Hospital

Herlev, 2730, Denmark
Hillerød Hospital

Hillerød, Denmark
Hvidovre Hospital

Hvidovre, Denmark
Odense sygehus

Odense, Denmark
Rigshospitalet

Copenhagen, 2100, Denmark
Roskilde Sygehus, Zealand University hospital

Roskilde, Denmark
Skejby Sygehus

Aarhus, Denmark
Skåne University Hospital

Lund, Sweden
Vejle Hospital

Vejle, Denmark
Viborg Hospital

Viborg, Denmark

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