Timing of dialysis in septic shock: early vs. delayed – study halted early

NCT ID NCT01682590

Terminated Disease control Sponsor: Centre Hospitalier Universitaire Dijon Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at 500 adults with septic shock and severe acute kidney injury to see if starting dialysis early (within 12 hours) or waiting (48-60 hours) affected survival at 90 days. The trial was terminated early, so the results are not conclusive. The goal was to find the best timing for dialysis in critically ill patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dialysis (renal replacement therapy)
What this could lead to: If successful, this could help doctors decide the best time to start dialysis for patients with septic shock and kidney failure, potentially improving survival.
What could go wrong: The trial was terminated early, so results are limited. It is unclear whether early or delayed dialysis is better, and findings may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute kidney injury toxic shock syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE RENAL FAILURE (AS DEFINED BY THE "FAILURE" STAGE OF THE RIFLE CLASSIFICATION) SEPTIC SHOCK

Contacts and locations

Locations

CH Avignon

Avignon, 84000, France
CH Belfort

Belfort, 90000, France
CH Dieppe

Dieppe, 76200, France
CH Périgueux

Périgueux, 24019, France
CH Sud Essonne - Site Etampes

Étampes, 91 150, France
CH de BOURG-EN-BRESSE

Bourg-en-Bresse, 01012, France
CH de LA ROCHE sur YON

La Roche-sur-Yon, 85000, France
CHG Mulhouse

Mulhouse, 68100, France
CHR Metz

Thionville, 57100, France
CHR d'Orléans

Orléans, 45100, France
CHRU Tours

Tours, France
CHU Besançon

Besançon, 25000, France
CHU Caen

Caen, 14003, France
CHU Clermont-Ferrand

Clermont-Ferrand, 63100, France
CHU Dijon

Dijon, 21000, France
CHU Grenoble

Grenoble, 38043, France
CHU Lapeyronie

Montpellier, 34295, France
CHU Lyon Sud

Pierre-Bénite, 69495, France
CHU Montpellier

Montpellier, 34000, France
CHU Nancy Brabois

Nancy, 54000, France
CHU Nîmes

Nîmes, 30000, France
CHU de Lyon

Lyon, 69000, France
CHU de Strasbourg - Nouvel hôpital civil

Strasbourg, 67000, France
Groupe Hospitalier de l'institut Catholique de LILLE

Lille, 59160, France
HOPITAL BICHAT Claude-Bernard

Paris, 75018, France
Hôpital Cochin

Paris, 75014, France
Hôpital Raymond-Poincaré GARCHES (AP-HP)

Garches, 92380, France

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