Can a week of antibiotics beat a kidney infection?
NCT ID NCT01390623
First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time
Summary
This trial tests whether a 7-day antibiotic course—starting with an intravenous dose of ceftriaxone followed by oral cefixime—can effectively treat acute uncomplicated pyelonephritis (a kidney infection) in women aged 18 to 65. The goal is to see if this shorter regimen works as well as longer standard treatments, while potentially reducing antibiotic use and resistance. Researchers will check for microbiological cure at day 9 and monitor for recurrence within a month.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- A 7-day antibiotic course: ceftriaxone given intravenously on the first day, followed by cefixime taken orally from the second to the seventh day.
- What this could lead to
- If successful, this shorter antibiotic regimen could offer a simpler, cost-effective treatment for kidney infections in women, potentially reducing the use of fluoroquinolones and slowing antibiotic resistance.
- What could go wrong
- This is a small, early-phase trial with only 39 participants, so results may not apply broadly. The shorter treatment might be less effective than standard longer courses, and there is a risk of infection recurrence or microbiological failure.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHU de Clermont-Ferrand
Clermont-Ferrand, 63003, France