New 5-in-1 meningitis vaccine shows promise in early trial
NCT ID NCT06128733
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a new investigational vaccine (MenPenta) designed to protect against five types of meningococcal bacteria (A, B, C, W, Y) that cause meningitis and bloodstream infections. Around 1,200 healthy adolescents and adults received either the new vaccine or existing vaccines to compare safety and immune response. The goal is to see if a single shot can replace multiple vaccines.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Pentavalent Meningococcal ABCYW vaccine (MenPenta)
- What this could lead to
- If successful, this could lead to a single vaccine that protects against five meningococcal serogroups (A, B, C, W, Y), simplifying vaccination schedules.
- What could go wrong
- This is an early-phase trial (I/II) focused on safety and immune response, not yet proven to prevent disease. Results may not confirm broad protection or long-term safety.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AES Peoria- Site Number : 8400090
Peoria, Illinois, 61614, United States
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AMR - Newton- Site Number : 8400104
Newton, Kansas, 67114, United States
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AMR Evansville Site Number : 8400062
Evansville, Indiana, 47712, United States
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AMR Utah-Wee Care Pediatrics-Kaysville- Site Number : 8400106
Kaysville, Utah, 84037, United States
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Accel Clinical Research-Deland Clinical Research Unit- Site Number : 8400081
DeLand, Florida, 32720-0834, United States
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Accel Research - Nona Pediatric Center Site Number : 8400079
Orlando, Florida, 32829, United States
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Accel Research Site - Birmingham Clinical Research Unit- Site Number : 8400080
Birmingham, Alabama, 35216, United States
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Accel Research Sites-St. Petersburg-Largo- Site Number : 8400082
Largo, Florida, 33777, United States
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Advances in Health- Pearland- Site Number : 8400078
Pearland, Texas, 77584, United States
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Alivation Research (Primary Care) Site Number : 8400046
Lincoln, Nebraska, 68526, United States
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Alliance for Multispecialty Research- Phoenix- Site Number : 8400056
Tempe, Arizona, 85281, United States
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Alliance for Multispecialty Research- Site Number : 8400107
Murray, Utah, 84107, United States
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Apex Research Group Site Number : 8400071
Fair Oaks, California, 95628, United States
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Be Well Clinical Studies -Round Rock Site Number : 8400053
Round Rock, Texas, 78681, United States
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Be Well Clinical Studies- Site Number : 8400077
Lincoln, Nebraska, 68516, United States
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Charisma Medical and Research center Site Number : 8400097
Miami Lakes, Florida, 33014, United States
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Coastal Carolina Research Center - N Charleston- Site Number : 8400050
North Charleston, South Carolina, 29405, United States
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DM Clinical Research- Bellaire- Site Number : 8400052
Houston, Texas, 77081, United States
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Harrisburg Family Medical Center Site Number : 8400070
Harrisburg, Arkansas, 72432, United States
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Hope Clinical Research, LLC- Site Number : 8400001
Canoga Park, California, 91303, United States
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Investigational Site Number : 6300001
San Juan, 00918, Puerto Rico
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Lakeview Clinical Research Site Number : 8400029
Guntersville, Alabama, 35976-2206, United States
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Leavitt Clinical Research-Idaho Falls- Site Number : 8400075
Idaho Falls, Idaho, 83404, United States
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Life Arc Research-Miami Site Number : 8400094
Miami, Florida, 33126, United States
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Michael W. Simon, MD, PSC- Site Number : 8400026
Lexington, Kentucky, 40517, United States
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Monroe Biomedical Research - Site Number : 8400099
Monroe, North Carolina, 28112, United States
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New Horizon Medical Group-Houston Site Number : 8400069
Houston, Texas, 77063, United States
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Ormond Beach Clinical Research- Site Number : 8400073
Ormond Beach, Florida, 32174, United States
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PAS Research Site Number : 8400032
Tampa, Florida, 33613, United States
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Palm Harbor Dermatology- Site Number : 8400030
Tampa, Florida, 33609, United States
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Pediatric Clinical Trials Tullahoma- Site Number : 8400020
Tullahoma, Tennessee, 37388, United States
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Prime Global Research, Inc. Site Number : 8400043
The Bronx, New York, 10456, United States
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Progressive Clinical Research- Site Number : 8400028
Bountiful, Utah, 84010, United States
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Quality Clinical Research, Inc.- Site Number : 8400074
Omaha, Nebraska, 68114, United States
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SIMEDHealth, LLC- Site Number : 8400045
Gainesville, Florida, 32607, United States
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SPICA Clinical Research Site Number : 8400098
Columbia, South Carolina, 29223, United States
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Smart Cures Clinical Research Site Number : 8400072
Anaheim, California, 92806, United States
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Snake River Research, PLLC- Site Number : 8400100
Idaho Falls, Idaho, 83404, United States
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South Florida Research Organization Site Number : 8400086
Medley, Florida, 33166, United States
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Tribe Clinical Research at Parkside Pediatrics-Five Forks Site Number : 8400049
Simpsonville, South Carolina, 29681, United States
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VICIS Clinical Research-Tampa Site Number : 8400065
Tampa, Florida, 33614, United States
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Velocity Clinical Research, Omaha- Site Number : 8400066
Omaha, Nebraska, 68134, United States
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Velocity Clinical Research-Albuquerque- Site Number : 8400101
Albuquerque, New Mexico, 87107, United States
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Velocity Clinical Research-Washington DC Site Number : 8400102
Washington D.C., District of Columbia, 20016, United States
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Vida Clinical Studies Site Number : 8400084
Dearborn Heights, Michigan, 48127-2234, United States
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Vida Clinical Studies- Site Number : 8400084
Dearborn Heights, Michigan, 48127-2234, United States
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~Kentucky Pediatics / Adult Research- Site Number : 8400009
Bardstown, Kentucky, 40004, United States
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