Plague treatment showdown: ciprofloxacin vs doxycycline
NCT ID NCT01243437
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether the antibiotic ciprofloxacin works as well as doxycycline for treating plague, a serious bacterial infection. Only 5 people in Uganda took part, and they were randomly assigned to one of the two drugs. The goal was to see if ciprofloxacin could be a good alternative treatment, especially in places where other options are limited.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ciprofloxacin and doxycycline
- What this could lead to
- If ciprofloxacin works as well as doxycycline, it could provide another treatment option for plague, especially in areas where doxycycline is hard to get or can't be used.
- What could go wrong
- This is a very small study (only 5 people) and early-stage (Phase 2), so results may not apply broadly. Ciprofloxacin's effectiveness against plague in humans is still not well proven.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Uganda Ministry of Health: selected Arua and Nebbi district health centres
Arua, Uganda
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Other studies related to the condition(s) this trial covers.