Can a 2-Month TB prevention be as good as 4 months?
NCT ID NCT03988933
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether taking a higher dose of the drug rifampin for 2 months is as safe and effective as the standard 4-month dose for treating latent tuberculosis (TB) infection. Over 1,300 adults and children aged 10 and older with latent TB were randomly assigned to receive either the standard dose for 4 months, or a double or triple dose for 2 months. The goal is to find a shorter, easier-to-complete treatment that prevents latent TB from becoming active.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Rifampin
What this could lead to
If successful, this could lead to a shorter, 2-month treatment for latent TB, making it easier for people to complete therapy and prevent active TB.
What could go wrong
This is a Phase 2 trial, so results are preliminary. Higher doses may cause more side effects, and the shorter regimen might not be as effective as the standard 4-month course.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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BCCDC TB clinic
Vancouver, British Columbia, Canada
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Hai Ba Trung District Health Center, No. 16B
Hà Nội, Vietnam
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Hanoi Lung Hospital
Hà Nội, Vietnam
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MUHC
Montreal, Quebec, H4A 3J1, Canada
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Nam Tu Liem District Health Center, No. 3
Hà Nội, Vietnam
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Phoi Viet TB and Respiratory Diseases Clinic.
Ho Chi Minh City, Vietnam
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The Governors of the University of Alberta
Edmonton, Alberta, T6G 2C8, Canada
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Universitas Padjadjaran, Klinik Penelitian Tuberculosis (TB research clinic)
Bandung, Indonesia
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Unviversity of Calgary
Calgary, Alberta, Canada