Can a 2-Month TB prevention be as good as 4 months?

NCT ID NCT03988933

Completed Disease control Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether taking a higher dose of the drug rifampin for 2 months is as safe and effective as the standard 4-month dose for treating latent tuberculosis (TB) infection. Over 1,300 adults and children aged 10 and older with latent TB were randomly assigned to receive either the standard dose for 4 months, or a double or triple dose for 2 months. The goal is to find a shorter, easier-to-complete treatment that prevents latent TB from becoming active.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Rifampin
What this could lead to: If successful, this could lead to a shorter, 2-month treatment for latent TB, making it easier for people to complete therapy and prevent active TB.
What could go wrong: This is a Phase 2 trial, so results are preliminary. Higher doses may cause more side effects, and the shorter regimen might not be as effective as the standard 4-month course.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for LATENT TUBERCULOSIS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

latent tuberculosis infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LATENT TUBERCULOSIS

Contacts and locations

Locations

BCCDC TB clinic

Vancouver, British Columbia, Canada
Hai Ba Trung District Health Center, No. 16B

Hà Nội, Vietnam
Hanoi Lung Hospital

Hà Nội, Vietnam
MUHC

Montreal, Quebec, H4A 3J1, Canada
Nam Tu Liem District Health Center, No. 3

Hà Nội, Vietnam
Phoi Viet TB and Respiratory Diseases Clinic.

Ho Chi Minh City, Vietnam
The Governors of the University of Alberta

Edmonton, Alberta, T6G 2C8, Canada
Universitas Padjadjaran, Klinik Penelitian Tuberculosis (TB research clinic)

Bandung, Indonesia
Unviversity of Calgary

Calgary, Alberta, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.