TB prevention breakthrough? 6-Week regimen could replace months of treatment

NCT ID NCT03474029

Recruiting now Prevention Sponsor: Centers for Disease Control and Prevention Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares a new 6-week daily rifapentine regimen to the standard 12-16 week rifamycin-based treatment for latent tuberculosis infection (LTBI). The goal is to see if the shorter treatment is just as safe and effective at preventing active TB. About 3,400 people at higher risk for TB will participate and be followed for 2 years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

latent tuberculosis infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LATENT TUBERCULOSIS

Contacts and locations

Locations

British Columbia Centre for Disease Control
RECRUITING

Vancouver, British Columbia, Canada
Calgary TB Clinic
RECRUITING

Calgary, Alberta, T1Y 6H6, Canada
Denver Health and Hospital Authority
RECRUITING

Denver, Colorado, 80204, United States
Desmond Tutu TB Center
NOT_YET_RECRUITING

Stellenbosch, South Africa
Edmonton TB Clinic
RECRUITING

Edmonton, Alberta, Canada
George Washington University
RECRUITING

Washington D.C., District of Columbia, 20001, United States
Ho Chin Minh City-District 6 TB Unit
RECRUITING

Ho Chi Minh City, Vietnam
Ho Chin Minh City-Phoi Viet Resportory Centre
RECRUITING

Ho Chi Minh City, Vietnam
Joint Clinical Research Centre/ Makerere Univ Med Sch
RECRUITING

Kampala, Uganda
Les Centres Gheskio (INLR) CRS
RECRUITING

Port-au-Prince, Haiti
Liverpool Hospital
RECRUITING

Sydney, Australia
McGill University Health Centre
RECRUITING

Montreal, Quebec, H3A 0G4, Canada
National Referral University Hospital for Pneumo-physiology
ACTIVE_NOT_RECRUITING

Cotonou, Benin
New York City Bureau of TB Control
RECRUITING

New York, New York, 11201, United States
New York Harbor Healthcare System
RECRUITING

Manhattan, New York, 10001, United States
Paramatta Chest
RECRUITING

Sydney, Australia
Royal Prince Alfred Hospital
RECRUITING

Sydney, Australia
San Antonio VA
ACTIVE_NOT_RECRUITING

San Antonio, Texas, 78201, United States
Seattle King County Health Department
RECRUITING

Seattle, Washington, 98101, United States
Toronto Western Hospital
RECRUITING

Toronto, Ontario, M5P 1N5, Canada
Washington DC VA Medical Center
RECRUITING

Washington D.C., District of Columbia, 20001, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.