Longer TB prevention pill cuts risk in HIV patients
NCT ID NCT00164281
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether taking the tuberculosis prevention drug isoniazid for 36 months instead of the usual 6 months could better prevent TB in adults with HIV. Nearly 2,000 participants in Botswana were randomly assigned to either short or long treatment. The goal was to see if longer therapy reduces new TB cases and deaths.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
isoniazid
What this could lead to
If successful, this could show that extending isoniazid preventive therapy beyond 6 months reduces tuberculosis cases in people with HIV.
What could go wrong
This is a completed Phase 4 trial, so results are already known. However, the benefit may not apply to all populations or settings, and isoniazid can cause liver side effects.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Gaborone and Francistown Health Clinics
Gaborone, Botswana