Could a Lower-Dose polio vaccine help eradicate the disease?
NCT ID NCT06413121
First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time
Summary
This study tests a hexavalent vaccine that protects against six diseases, including polio, but uses a lower dose of the inactivated polio vaccine (IPV). The goal is to see if this reduced-dose version works as well as the standard full-dose vaccine in infants. Around 1,500 healthy infants aged 6-8 weeks will receive three primary doses and a booster. If effective, this approach could lower costs and increase vaccine supply, aiding global polio eradication.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Hexavalent (DTwP-HepB-IPV-Hib) vaccine with reduced dose IPV
- What this could lead to
- If successful, this vaccine could help make polio protection more affordable and available worldwide, supporting global eradication efforts.
- What could go wrong
- This is a phase 3 trial, but reducing the IPV dose might still result in lower immune responses for some infants. Safety and effectiveness need confirmation.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Bharati Vidyapeeth Medical College and Hospital, Pune
Pune, Maharashtra, 411043, India
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Hamdard Institute of Medical Sciences and Research (HIMSR) with Centre for health research & Development, Society for applied studies, Hakeem Abdul Hameed Centenary Hospital (HAHCH)
New Delhi, National Capital Territory of Delhi, 110062, India
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Institute of Child Health, Kolkata
Kolkata, West Bengal, 700017, India
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International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Kamalapur Field office, Lichubagan Rd
Dhaka, Dhaka Division, 1204, Bangladesh
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International Centre for Diarrhoeal Disease Research, Bangladesh (Icddr,b), Clinical Trial Unit (CTU), Adjacent to the main center, 68, Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka
Dhaka, Dhaka Division, 1212, Bangladesh
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International Centre for Diarrhoeal Disease Research, Bangladesh (Icddr,b), Matlab Field office, MHRC Internal Road, Matlab Bazar
Chāndpur, 3640, Bangladesh
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JSS Medical College and Hospital
Mysore, Karnataka, 570004, India
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KEM Hospital and Research Centre, Vadu
Pune, Maharashtra, 412216, India
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Manipal Academy of Higher Education, Manipal
Mangalore, Karnataka, 576104, India
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Post Graduate Institute of Medical Education and Research (PGIMER)
Chandigarh, Chandigarh, 160012, India
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Sri Ramachandra Medical Centre, Chennai
Chennai, Tamil Nadu, 600116, India