Could a simple pill replace daily IV drips for skin infections?

NCT ID NCT00323219

Completed Disease control Sponsor: University of British Columbia Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether an oral antibiotic (moxifloxacin) works as well as a standard intravenous (IV) antibiotic (cefazolin) for treating moderate skin infections (cellulitis) in the emergency department. 390 patients with moderate cellulitis were treated either with daily IV antibiotics for 3-5 days or with oral moxifloxacin. The goal was to see if the oral option could be just as effective, potentially saving patients from daily hospital visits.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: moxifloxacin (oral antibiotic) and cefazolin (intravenous antibiotic) with probenecid
What this could lead to: If oral moxifloxacin works as well as IV antibiotics, patients with moderate cellulitis could avoid daily hospital visits for IV treatment.
What could go wrong: This is a completed Phase 3 trial, so results are available. However, oral antibiotics may not be as effective for all types of infections, and some patients may still need IV therapy.

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Conditions

The condition(s) this trial relates to.

cellulitis Emergencies

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CELLULITIS

Contacts and locations

Locations

St. Paul's Hospital, Providence Healthcare, Emergency Medicine

Vancouver, British Columbia, V1Y 1Z1, Canada

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