New antibiotic mix aims to tame tough stomach bug with fewer side effects
NCT ID NCT06561711
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested different doses of the antibiotics minocycline and metronidazole, combined with bismuth and a stomach acid blocker, to treat Helicobacter pylori infections that didn't clear with previous treatments. 480 adults who had failed earlier therapy were randomly assigned to one of several 14-day regimens. The goal was to find a combination that kills the bacteria just as well as the standard treatment but causes fewer side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
minocycline and metronidazole (antibiotics) plus vonoprazan and bismuth potassium citrate
What this could lead to
If successful, this could provide a more tolerable and effective antibiotic combination for people with stubborn H. pylori infections that haven't cleared with earlier treatments.
What could go wrong
This is a Phase 4 trial comparing existing drugs, so no major breakthrough is expected. Side effects from the antibiotics are common, and the best regimen may still cause discomfort.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for HELICOBACTER PYLORI INFECTION are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Peking University Third Hospital
Beijing, Beijing Municipality, 100191, China
-
Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Shanghai, Shanghai Municipality, 200127, China
-
Songjiang Hospital, School of Medicine, Shanghai Jiao Tong University
Shanghai, Shanghai Municipality, China
-
The Second Affiliated Hospital of Zhejiang University school of Medicine
Hangzhou, Zhejiang, China