New antibiotic mix aims to tame tough stomach bug with fewer side effects

NCT ID NCT06561711

Completed Disease control Sponsor: Shanghai Jiao Tong University School of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested different doses of the antibiotics minocycline and metronidazole, combined with bismuth and a stomach acid blocker, to treat Helicobacter pylori infections that didn't clear with previous treatments. 480 adults who had failed earlier therapy were randomly assigned to one of several 14-day regimens. The goal was to find a combination that kills the bacteria just as well as the standard treatment but causes fewer side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: minocycline and metronidazole (antibiotics) plus vonoprazan and bismuth potassium citrate
What this could lead to: If successful, this could provide a more tolerable and effective antibiotic combination for people with stubborn H. pylori infections that haven't cleared with earlier treatments.
What could go wrong: This is a Phase 4 trial comparing existing drugs, so no major breakthrough is expected. Side effects from the antibiotics are common, and the best regimen may still cause discomfort.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cyclopia sequence Helicobacter pylori infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HELICOBACTER PYLORI INFECTION

Contacts and locations

Locations

Peking University Third Hospital

Beijing, Beijing Municipality, 100191, China
Renji Hospital, School of Medicine, Shanghai Jiao Tong University

Shanghai, Shanghai Municipality, 200127, China
Songjiang Hospital, School of Medicine, Shanghai Jiao Tong University

Shanghai, Shanghai Municipality, China
The Second Affiliated Hospital of Zhejiang University school of Medicine

Hangzhou, Zhejiang, China

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