Shanghai Jiao Tong University School Of Medicine

This study tests giving chemotherapy before surgery to men with high-risk prostate cancer. The goal is to see if this approach helps keep the cancer from coming back for at least 5 years. About 300 men aged 40-75 with early-stage but high-risk prostate cancer will receive one of …

This early study tests a personalized mRNA vaccine (mRNA-0523-L001) in 21 adults with advanced endocrine tumors, such as adrenal, thyroid, or pancreatic cancers, that have not responded to standard treatments. The vaccine is designed to train the immune system to attack each pati…

This study tests a new treatment called CS-121 for children aged 4 to 18 with a rare condition that causes extremely high levels of fat in the blood. The therapy uses gene editing to lower these fat levels and reduce the risk of serious health problems. The main goal is to check …

This study tests whether a combination of two drugs, Sac-TMT and KL-A167, can shrink or eliminate triple-negative breast tumors before surgery. About 40 adults with early-stage, non-metastatic triple-negative breast cancer will receive the treatment. The goal is to see if this ap…

This study compares two different drug combinations given before surgery for early or locally advanced HER2-positive breast cancer. About 60 adults will be randomly assigned to receive either pyrotinib plus trastuzumab and docetaxel or pertuzumab plus trastuzumab and docetaxel. R…

This study tests a treatment called Magnetic Seizure Therapy (MST) for people with psychotic disorders like schizophrenia. The therapy uses magnetic pulses to trigger a controlled seizure in the brain, aiming to improve symptoms when added to regular medication. About 50 adults a…

This study tests a new drug combination (trastuzumab deruxtecan plus pertuzumab) given before surgery to shrink tumors in people with HER2-positive breast cancer. If the tumor shrinks enough, they continue the same drugs; if not, they switch to another combo. The goal is to see h…

This study compares a reduced dose (35mg/kg) versus the standard dose (50mg/kg) of a drug called cyclophosphamide, given after a stem cell transplant to prevent graft-versus-host disease (GVHD). About 316 people receiving a transplant from a matched unrelated or half-matched dono…

This study tests a reduced-intensity chemotherapy combination (fludarabine, busulfan, and melphalan) given before a stem cell transplant in people aged 55 and older with certain blood cancers (AML, MDS, CMML). The goal is to see if this gentler approach can help patients stay fre…

This study tests whether Shenling Baishu Granule, a traditional Chinese medicine, can prevent low-risk colorectal adenomas (non-cancerous colon polyps) from returning after removal. About 624 adults who recently had polyps removed will take the granules or no treatment for 3 year…

This study tests a new system for teenagers with scoliosis who need to wear a back brace for many hours a day. The system uses small sensors in the brace, a home device with fun progress feedback, and a mobile app to track wear time and motivation. The goal is to see if this appr…

This study aims to create a standardized quality system for confocal enteroscopy, a technique that lets doctors see cells in real time during a small bowel exam. Researchers will enroll 600 people and their doctors to test how well the procedure works and how accurate the diagnos…

This study looks at whether taking common acid-reducing drugs (proton pump inhibitors, or PPIs) changes the accuracy of a stool DNA test for H. pylori infection. About 25 adults who need long-term PPI treatment will provide stool and stomach samples while on the drug and again af…

This study looks at 60 children with lupus to find early signs of heart problems using non-invasive ultrasound techniques. The goal is to identify those at higher risk for heart issues. Participants must be under 18 and meet lupus criteria. The study does not offer treatment but …

This study looks at 8,000 obese young adults in China to find out how genes and other factors contribute to obesity and related health problems like metabolic syndrome. Participants must have a BMI of 30 or higher and be from eastern China. The goal is to learn more about the cau…

This study will gather detailed information from 600 adults with adrenal diseases, such as Cushing's syndrome and adrenal tumors. The goal is to improve how these conditions are diagnosed and treated by studying patient data over time. Participants will not receive a new treatmen…

This study tests whether a special light during colonoscopy helps doctors find more precancerous polyps than the standard light. About 800 adults aged 45 to 85 getting a colonoscopy will take part. The goal is to see if the enhanced light improves detection without changing the p…