Shanghai Jiao Tong University School Of Medicine

This study tests a new combination of drugs given before surgery for people with HER2-positive breast cancer. About 50 participants will receive the drugs to see if the tumor shrinks enough to avoid more chemotherapy. If the tumor does not shrink enough, patients will switch to a…

This study tests two different drug combinations given before surgery for early or locally advanced HER2-positive breast cancer. The goal is to see which combination clears cancer DNA from the blood faster, which may predict better outcomes. About 60 participants will be randomly…

This study tests a new treatment called CS-121 for children aged 4 to 18 with a rare condition that causes extremely high fat levels in the blood (hyperchylomicronemia). The treatment uses gene-editing technology to target a specific gene and lower fat levels. The goal is to see …

This study tests a new, faster version of magnetic seizure therapy (MST) for people with psychotic disorders like schizophrenia. The goal is to see if adding MST to standard antipsychotic medication can improve symptoms and thinking. Fifty adults aged 18-55 will receive the treat…

This study tests two drugs, Sac-TMT and KL-A167, given before surgery to people with early-stage triple-negative breast cancer. The goal is to see if the combination can eliminate or shrink the tumor enough to improve long-term outcomes. About 40 participants will receive the tre…

This study tests giving chemotherapy before surgery to men with high-risk prostate cancer. The goal is to see if this approach helps keep the cancer from coming back for at least 5 years. About 300 men aged 40-75 with early-stage but high-risk prostate cancer will receive one of …

This early study tests a personalized mRNA vaccine (mRNA-0523-L001) in 21 adults with advanced endocrine tumors, such as adrenal, thyroid, or pancreatic cancers, that have not responded to standard treatments. The vaccine is designed to train the immune system to attack each pati…

This study compares a reduced dose (35mg/kg) versus the standard dose (50mg/kg) of a drug called cyclophosphamide, given after a stem cell transplant to prevent graft-versus-host disease (GVHD). About 316 people receiving a transplant from a matched unrelated or half-matched dono…

This study tests a reduced-intensity chemotherapy combination (fludarabine, busulfan, and melphalan) given before a stem cell transplant in people aged 55 and older with certain blood cancers (AML, MDS, CMML). The goal is to see if this gentler approach can help patients stay fre…

This study tests whether Shenling Baishu Granule, a traditional Chinese medicine, can prevent low-risk colorectal adenomas (precancerous polyps) from returning after removal. About 624 adults who recently had polyps removed will take the granule or no treatment and be followed fo…

This study tests a new system for teenagers with scoliosis who need to wear a back brace for many hours a day. The system uses small sensors in the brace, a home device with fun progress feedback, and a mobile app to track wear time and motivation. The goal is to see if this appr…

This study is creating a large group of 600 adults with various adrenal diseases, such as Cushing's syndrome and adrenal tumors. The goal is to learn more about how these conditions work, improve how they are diagnosed, and find better ways to treat each person. Participants will…

This study looks at whether taking proton pump inhibitors (PPIs), common acid-reducing drugs, changes the accuracy of a stool DNA test for H. pylori infection. Researchers will test 25 adults who need long-term PPI therapy, comparing stool DNA test results while on PPIs and after…

This study looks at 8,000 young Chinese adults with obesity (BMI 30 or higher) to find genetic factors that may cause or contribute to obesity and related metabolic problems. Participants provide health information and samples for analysis. The goal is to better understand why so…

This study aims to create a standardized quality system for confocal enteroscopy, a technique that lets doctors see cells in real time during a small bowel exam. Researchers will enroll 600 people and their doctors to test how well the procedure works and how accurate the diagnos…

This study looks at 60 children with lupus to find early signs of heart problems using non-invasive ultrasound techniques. The goal is to identify those at higher risk for heart issues. Participants must be under 18 and meet lupus criteria. The study does not offer treatment but …

This study tests whether a special light during colonoscopy helps doctors find more precancerous polyps than the standard light. About 800 adults aged 45 to 85 getting a colonoscopy will take part. The goal is to see if the enhanced light improves detection without changing the p…