Shanghai Jiao Tong University School Of Medicine

This study tests whether a drug called chiglitazar, combined with anti-inflammatory and liver-protecting therapies, can improve liver health in people who have both MASH (a severe fatty liver disease) and type 2 diabetes. About 300 adults will receive either the drug combo or a p…

This early study tests a personalized mRNA vaccine (mRNA-0523-L001) for people with advanced endocrine tumors like adrenal cancer, medullary thyroid cancer, and pancreatic neuroendocrine tumors who have no standard treatment left. The vaccine is made to target unique mutations in…

This study tests whether a new drug combination (pyrotinib + trastuzumab + docetaxel) works better than the standard combo (pertuzumab + trastuzumab + docetaxel) for shrinking early-stage HER2-positive breast tumors before surgery. Researchers will use a blood test to measure tum…

This study tests whether a lower dose of the drug cyclophosphamide can prevent graft-versus-host disease (GVHD) after stem cell transplants from unrelated or half-matched donors. About 316 participants will receive either a reduced dose (35 mg/kg) or the standard dose (50 mg/kg),…

This phase 2 trial tests a reduced-intensity chemotherapy regimen (fludarabine, busulfan, melphalan) before stem cell transplant in 61 patients aged 55 and older with myeloid cancers like AML, MDS, or CMML. The goal is to see if this gentler approach can improve disease-free surv…

This study tests whether a combination of two targeted drugs (trastuzumab deruxtecan and pertuzumab) can shrink or eliminate HER2-positive breast tumors before surgery. About 50 women with stage II-III breast cancer will receive the drugs for three cycles. If the tumor responds w…

This phase II trial is testing a combination of two drugs—Sac-TMT (a targeted chemotherapy) and KL-A167 (an immunotherapy)—given before surgery to 40 people with triple-negative breast cancer. The goal is to see if the combo can eliminate or shrink tumors enough to improve long-t…

This early-stage trial tests a new gene-editing treatment called CS-121 in 15 children and teens (ages 4-18) with a rare condition causing extremely high triglycerides. The therapy uses lipid nanoparticles to deliver a base editor that targets the APOC3 gene in the liver. The mai…

This study tests whether giving chemotherapy before surgery can help control high-risk prostate cancer and prevent it from coming back or spreading. About 300 men aged 40 to 75 will receive one of four chemo drugs followed by prostate removal. The goal is to see if this approach …

This study tests a new treatment called magnetic seizure therapy (MST) for people with psychotic disorders like schizophrenia. MST uses magnetic pulses to trigger a controlled seizure in the brain, aiming to improve symptoms when added to standard antipsychotic medications. The t…

This study tests whether Shenling Baizhu granules, a traditional Chinese medicine, can prevent low-risk colorectal adenomas from recurring after they are removed during a colonoscopy. About 624 adults aged 18-70 will take the granules three times daily for six months or receive n…

This study tests a new system to help teenagers with scoliosis wear their corrective brace more consistently. The system uses sensors to track wear time and provides fun, interactive feedback through a home device and mobile app. Researchers want to see if this approach improves …

This study looks at whether taking common acid-reducing drugs (proton pump inhibitors, or PPIs) affects the accuracy of a stool DNA test for H. pylori, a stomach bacteria. Researchers will test 25 adults who need PPIs, first while on the drug and then after stopping it for 4 week…

This study is recruiting 8,000 young Chinese adults with obesity (BMI 30 or higher) to investigate how genes and clinical features contribute to obesity and metabolic syndrome. Researchers aim to better understand the underlying causes, which could eventually lead to improved tre…

This study looks at 60 children with lupus to find early signs of heart problems using non-invasive ultrasound. The goal is to identify which children are at higher risk for heart issues. No new treatments are being tested.

This study aims to create a standardized quality system for confocal enteroscopy, a technique that lets doctors see cells in real time during a small bowel exam. Researchers will enroll 600 people aged 18-70 who need small bowel endoscopy, along with certified gastroenterologists…

This study is building a large group of 600 adults with various adrenal diseases, like Cushing's syndrome and adrenal tumors. Researchers will track their standard treatments (surgery, radiation, or medication) and outcomes. The goal is to learn more about these conditions, impro…