Cure My Disease

Don't miss your cure!

 Log in / Sign up

New Two-Drug combo aims to stop leprosy spread in its tracks

NCT ID NCT05597280

Recruiting now Prevention Sponsor: Institute of Tropical Medicine, Belgium Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether a combination of two antibiotics (bedaquiline and rifampicin) can better prevent leprosy than the current standard single dose of rifampicin. Over 124,000 people living near a leprosy patient in the Comoros will receive either the new two-dose regimen or the standard one-dose treatment. Researchers will track who develops leprosy over several years to see if the new combo is more effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
bedaquiline and rifampicin
What this could lead to
If successful, this could provide a more effective way to prevent leprosy in people living near a patient, reducing new cases in high-risk communities.
What could go wrong
This is a large trial, but the new regimen may cause more side effects (like nausea or dizziness) than the current single-dose treatment. It also requires two doses, which may be harder to deliver.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for LEPROSY are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

leprosy prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LEPROSY

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Email: •••••@•••••

Locations

  • Fondation Damien

    RECRUITING

    Moroni, Comoros

    Contact Email: •••••@•••••

More trials for these conditions

Other studies related to the condition(s) this trial covers.