Pfizer launches massive trial for c. diff vaccine in seniors

NCT ID NCT07282665

Recruiting now ⭐️ VACCINE ⭐️ Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jan 05, 2026 · Last updated May 11, 2026 · Updated 17 times

Summary

This study tests whether a vaccine can prevent C. difficile infection, a serious gut infection often linked to antibiotic use. About 32,000 adults aged 65 and older will receive either the vaccine or a placebo shot. Researchers will track how many people get C. diff diarrhea over up to 3.5 years to see if the vaccine works.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AMR Clinical
RECRUITING

Newton, Kansas, 67114, United States
Accellacare - Cary
RECRUITING

Cary, North Carolina, 27518, United States
Accellacare - Hickory
RECRUITING

Hickory, North Carolina, 28601, United States
Accellacare - McFarland
RECRUITING

Ames, Iowa, 50010, United States
Accellacare - Raleigh
RECRUITING

Raleigh, North Carolina, 27609, United States
Accellacare - Salisbury
RECRUITING

Salisbury, North Carolina, 28144, United States
Accellacare - Wilmington
RECRUITING

Wilmington, North Carolina, 28401, United States
Accellacare - Winston-Salem
RECRUITING

Winston-Salem, North Carolina, 27103, United States
Albuquerque Clinical Trials, Inc.
RECRUITING

Albuquerque, New Mexico, 87102, United States
Angels Clinical Research Institute
RECRUITING

Tampa, Florida, 33614, United States
Applied Research Center of Arkansas
RECRUITING

Little Rock, Arkansas, 72205, United States
Atrium Health Wake Forest Baptist Infectious Disease-High Point
RECRUITING

High Point, North Carolina, 27262, United States
Bay Pines VA Healthcare System
NOT_YET_RECRUITING

Bay Pines, Florida, 33744, United States
Brunel Medical Practice (St Marychurch)
NOT_YET_RECRUITING

Torquay, Devon, TQ1 4QX, United Kingdom
CDC Centro Médico
NOT_YET_RECRUITING

Lujan de Cuyo, Mendoza Province, 5505, Argentina
CTI Clinical Research Center
RECRUITING

Cincinnati, Ohio, 45212, United States
Capital Area Research, LLC
RECRUITING

Camp Hill, Pennsylvania, 17011, United States
Carbon Health - San Mateo - Hillsdale Mall
RECRUITING

San Mateo, California, 94403, United States
Care Research Inc
RECRUITING

Miami, Florida, 33130, United States
Cedar Health Research - Euless
RECRUITING

Euless, Texas, 76040, United States
Centricity Research Columbus Georgia Multispecialty
RECRUITING

Columbus, Georgia, 31904, United States
Centro Medico Barrio Parque
RECRUITING

Buenos Aires, 1425, Argentina
Charisma Medical and Research Center
RECRUITING

Miami Lakes, Florida, 33014, United States
Cheadle Community Hospital
RECRUITING

Cheadle, Staffordshire, ST10 1NS, United Kingdom
Clinica Del Niño Y La Madre
RECRUITING

Mar del Plata, Buenos Aires, 7600, Argentina
Clinica Privada del Sol S.A
RECRUITING

Córdoba, Córdoba Province, X5000IIH, Argentina
Clinical Neuroscience Solutions Inc.
RECRUITING

Memphis, Tennessee, 38119, United States
Clinical Neuroscience Solutions, Inc. dba CNS Healthcare
RECRUITING

Jacksonville, Florida, 32256, United States
Clinical Research Partners, LLC
NOT_YET_RECRUITING

Richmond, Virginia, 23226, United States
Columbia University Irving Medical Center
NOT_YET_RECRUITING

New York, New York, 10032, United States
DM Clinical Research - Chicago
RECRUITING

Melrose Park, Illinois, 60160, United States
DM Clinical Research - Detroit
RECRUITING

Southfield, Michigan, 48076, United States
DM Clinical Research - Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
DM Clinical Research- Cyfair
RECRUITING

Houston, Texas, 77065, United States
Diablo Clinical Research, Inc.
RECRUITING

Walnut Creek, California, 94598, United States
Duke University Health System
RECRUITING

Raleigh, North Carolina, 27609, United States
Duke Vaccine and Trials Unit
RECRUITING

Durham, North Carolina, 27703, United States
Dynamed Clinical Research, LP d/b/a DM Clinical Research
RECRUITING

Tomball, Texas, 77375, United States
Emory Steiner Building Research Center
NOT_YET_RECRUITING

Atlanta, Georgia, 30303, United States
Emory University Woodruff Extension Building (WEB)
NOT_YET_RECRUITING

Atlanta, Georgia, 30303, United States
Entrust Clinical Research
RECRUITING

Miami, Florida, 33176, United States
Epic Medical Research-Sun City
RECRUITING

Sun City, Arizona, 85351, United States
Equipo Ciencia
RECRUITING

Buenos Aires, Buenos Aires F.D., C1428BNF, Argentina
Family Health Watch - KeyPoint Clinical Research
RECRUITING

Dallas, Texas, 75237, United States
Fundación Huésped
RECRUITING

Buenos Aires, Buenos Aires F.D., 1427, Argentina
GW Vaccine Research Unit
RECRUITING

Washington D.C., District of Columbia, 20037, United States
HMH David Jurist Research Building
RECRUITING

Hackensack, New Jersey, 07601, United States
HMH Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
HOPE Tower at Jersey Shore University Medical Center
RECRUITING

Neptune City, New Jersey, 07753, United States
Hackensack Meridian Health Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Hackensack Meridian Jersey Shore University Medical Center
RECRUITING

Neptune City, New Jersey, 07753, United States
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Indago Research & Health Center, Inc
RECRUITING

Hialeah, Florida, 33012, United States
Innovation Medical Research Center
NOT_YET_RECRUITING

Palmetto Bay, Florida, 33157, United States
Investigaciones Clínicas Salta (ICSAL)
NOT_YET_RECRUITING

Salta, A4400, Argentina
J. Lewis Research, Inc. / Foothill Family Clinic South
RECRUITING

Salt Lake City, Utah, 84121, United States
Johns Hopkins Bloomberg School of Public Health
NOT_YET_RECRUITING

Baltimore, Maryland, 21205, United States
Kaiser Permanente - San Diego Medical Center
RECRUITING

San Diego, California, 92123, United States
Kaiser Permanente Center for Health Research
RECRUITING

Portland, Oregon, 97227, United States
Kaiser Permanente Daly City
RECRUITING

Daly City, California, 94015, United States
Kaiser Permanente Los Angeles Medical Center
RECRUITING

Los Angeles, California, 90027, United States
Kaiser Permanente Oakland
NOT_YET_RECRUITING

Oakland, California, 94611, United States
Kaiser Permanente Oncology Pharmacy #014C
RECRUITING

Los Angeles, California, 90027, United States
Kaiser Permanente Ontario Medical Center
RECRUITING

Ontario, California, 91761, United States
Kaiser Permanente Roseville
RECRUITING

Roseville, California, 95661, United States
Kaiser Permanente Sacramento
RECRUITING

Sacramento, California, 95815, United States
Kaiser Permanente San Jose
RECRUITING

San Jose, California, 95119, United States
Kaiser Permanente Santa Clara
RECRUITING

Santa Clara, California, 95051, United States
Kaiser Permanente South Sacramento
RECRUITING

Sacramento, California, 95823, United States
Kaiser Permanente Viewridge Medical Office
RECRUITING

San Diego, California, 92123, United States
Kaiser Permanente Walnut Creek
RECRUITING

Walnut Creek, California, 94596, United States
Kaiser Permanente Washington Health Research Institute (KPWHRI)
NOT_YET_RECRUITING

Seattle, Washington, 98101, United States
KeyPoint Clinical Research
RECRUITING

Dallas, Texas, 75240, United States
Knowle House Surgery
RECRUITING

Plymouth, Devon, PL5 3JB, United Kingdom
Lakeside Surgery
RECRUITING

Corby, Northamptonshire, NN17 2UR, United Kingdom
Lakeview Clinical Research
RECRUITING

Guntersville, Alabama, 35976, United States
Layton Medical Centre
RECRUITING

Blackpool, Lancashire, FY3 7EN, United Kingdom
M3 Wake Research - Lake City
RECRUITING

Lake City, Florida, 32055, United States
Manchester Royal Infirmary
NOT_YET_RECRUITING

Manchester, M13 9WU, United Kingdom
McFarland Clinic, PC
RECRUITING

Ames, Iowa, 50010, United States
Med Partners, Inc. dba Premiere Medical Center of Burbank, Inc.
RECRUITING

Toluca Lake, California, 91602, United States
Medical Affiliated Research Center
RECRUITING

Huntsville, Alabama, 35801, United States
Medication Management
RECRUITING

Greensboro, North Carolina, 27405, United States
Memorial Hermann Hospital - TMC
NOT_YET_RECRUITING

Houston, Texas, 77030, United States
Mercury Clinical Research - Santa Clara Family Clinic
RECRUITING

Houston, Texas, 77087, United States
Montefiore Medical Center
RECRUITING

The Bronx, New York, 10467, United States
Mount Sinai Morningside
RECRUITING

New York, New York, 10025, United States
Mount Sinai Queens
RECRUITING

Long Island City, New York, 11102, United States
Mount Sinai West
RECRUITING

New York, New York, 10019, United States
NYU Langone Health
RECRUITING

Brooklyn, New York, 11220, United States
NYU Langone Health
RECRUITING

Mineola, New York, 11501, United States
NYU Langone Health
RECRUITING

New York, New York, 10016, United States
New Phase Research and Development
RECRUITING

Knoxville, Tennessee, 37909, United States
Newquay Health Centre
RECRUITING

Newquay, Cornwall, TR7 1RU, United Kingdom
North Alabama Research Center
RECRUITING

Athens, Alabama, 35611, United States
North Shore University Hospital
RECRUITING

Manhasset, New York, 11030, United States
North Texas Infectious Diseases Consultants, P.A
RECRUITING

Dallas, Texas, 75246, United States
North Wales Clinical Research Facility
NOT_YET_RECRUITING

Wrexham, Wrexham [wrecsam Gb-wrc], LL13 7YP, United Kingdom
Northern Westchester Hospital
RECRUITING

Mount Kisco, New York, 10549, United States
Northwell Health Infectious Disease
RECRUITING

Manhasset, New York, 11030, United States
Northwest Houston Heart Center
RECRUITING

Tomball, Texas, 77375, United States
Ochsner Clinic Foundation - Kenner Clinical Trials Unit
NOT_YET_RECRUITING

Kenner, Louisiana, 70065, United States
Ochsner Lafayette General Medical Center
NOT_YET_RECRUITING

Lafayette, Louisiana, 70503, United States
Ochsner Medical Complex - The Grove
NOT_YET_RECRUITING

Baton Rouge, Louisiana, 70836, United States
Ormeau Clinical Trials
RECRUITING

Belfast, Northern Ireland, BT2 8BG, United Kingdom
Palm Springs Community Health Center
NOT_YET_RECRUITING

Miami Lakes, Florida, 33014, United States
Panthera Biopartners - Glasgow
RECRUITING

Glasgow, G51 4RY, United Kingdom
Panthera Biopartners - Manchester
RECRUITING

Rochdale, Manchester, OL11 4AU, United Kingdom
Panthera Biopartners - Preston
RECRUITING

Preston, England, PR2 9QB, United Kingdom
Panthera Biopartners - Sheffield
RECRUITING

Sheffield, S2 5FX, United Kingdom
Panthera Clinic - York
RECRUITING

York, North Yorkshire, YO24 4LJ, United Kingdom
Phelps Hospital Geriatric Medicine & Improvement Science
RECRUITING

Sleepy Hollow, New York, 10591, United States
Proactive Clinical Research,LLC
RECRUITING

Fort Lauderdale, Florida, 33308, United States
Providence Regional Medical Center Everett
NOT_YET_RECRUITING

Everett, Washington, 98201, United States
Renown Center for Advanced Medicine
RECRUITING

Reno, Nevada, 89502, United States
Renown Regional Medical Center
RECRUITING

Reno, Nevada, 89502, United States
Revive Research Institute, Inc.
RECRUITING

Southfield, Michigan, 48075, United States
Rochester Clinical Research, LLC
RECRUITING

Rochester, New York, 14609, United States
Royal Devon & Exeter Hospital
RECRUITING

Exeter, Devon, EX2 5DW, United Kingdom
Rutgers Robert Wood Johnson Medical School
NOT_YET_RECRUITING

New Brunswick, New Jersey, 08901, United States
Sacramento VA Medical Center
NOT_YET_RECRUITING

Mather, California, 95655, United States
Sanatorio Sagrado Corazón
RECRUITING

Buenos Aires, 1039, Argentina
South Florida Research Organization
RECRUITING

Medley, Florida, 33166, United States
South Jersey Infectious Disease
RECRUITING

Somers Point, New Jersey, 08244, United States
Southampton General Hospital
RECRUITING

Southampton, Hampshire, SO16 6YD, United Kingdom
Sundance Clinical Research
RECRUITING

St Louis, Missouri, 63141, United States
Synexus Manchester Clinical Research Centre
RECRUITING

Manchester, M15 6SE, United Kingdom
Synexus Midlands Clinical Research Centre
NOT_YET_RECRUITING

Birmingham, WEST Midlands, B15 2SQ, United Kingdom
Synexus Scotland Clinical Research Centre
NOT_YET_RECRUITING

Glasgow, Glasgow CITY, ML4 3NJ, United Kingdom
The GW Medical Faculty Associates
RECRUITING

Washington D.C., District of Columbia, 20037, United States
The Hope Clinic of Emory University
RECRUITING

Decatur, Georgia, 30030, United States
The University of Texas Health Science Center at Houston
NOT_YET_RECRUITING

Houston, Texas, 77030, United States
The University of Vermont Medical Center Inc.
NOT_YET_RECRUITING

Burlington, Vermont, 05401, United States
The Vanderbilt Vaccine Research Program Clinic at The Village at Vanderbilt
NOT_YET_RECRUITING

Nashville, Tennessee, 37212, United States
Tokyo-Eki Center-building Clinic
NOT_YET_RECRUITING

Chuo-ku, Tokyo, 103-0027, Japan
Trial Management Associates
RECRUITING

Myrtle Beach, South Carolina, 29572, United States
Trial Management Associates, LLC
RECRUITING

Myrtle Beach, South Carolina, 29572, United States
UT Physicians
NOT_YET_RECRUITING

Houston, Texas, 77030, United States
UVM Larner College of Medicine MMG/VCT
NOT_YET_RECRUITING

Burlington, Vermont, 05401, United States
University Health
RECRUITING

Reno, Nevada, 89519, United States
University Of Nebraska Medical Center
NOT_YET_RECRUITING

Omaha, Nebraska, 68198, United States
University of Nebraska Medical Center
NOT_YET_RECRUITING

Omaha, Nebraska, 68105, United States
University of Washington - Harborview Medical Center
RECRUITING

Seattle, Washington, 98104, United States
Upstate Global Health Institute
RECRUITING

East Syracuse, New York, 13057, United States
VA Northeast Ohio Healthcare System Louis Stokes Cleveland VA Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
Vanderbilt Investigational Drug Service (IDS)
NOT_YET_RECRUITING

Nashville, Tennessee, 37232, United States
Vanderbilt University Medical Center
NOT_YET_RECRUITING

Nashville, Tennessee, 37232, United States
Vanderbilt Vaccine Research Program
NOT_YET_RECRUITING

Nashville, Tennessee, 37232, United States
Vanderbilt Vaccine Research Program Laboratory
NOT_YET_RECRUITING

Nashville, Tennessee, 37232, United States
Velocity Clinical Research, Grand Island
RECRUITING

Grand Island, Nebraska, 68803, United States
Velocity Clinical Research, Omaha
RECRUITING

Omaha, Nebraska, 68134, United States
Velocity Clinical Research, San Bernardino
RECRUITING

San Bernardino, California, 92408, United States
Velocity Clinical Research, Savannah
RECRUITING

Savannah, Georgia, 31406, United States
Velocity Clinical Research, Sioux City
RECRUITING

Sioux City, Iowa, 51106, United States
Velocity Clinical Research, Spartanburg
RECRUITING

Spartanburg, South Carolina, 29303, United States
Wake Forest Baptist Health
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Walker Family Care
RECRUITING

Little River, South Carolina, 29566, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.

CLOSTRIDIOIDES DIFFICILE ASSOCIATED DISEASE