Can a simple drink mix keep UTIs away? new trial seeks answers
NCT ID NCT07453693
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This 6-month study tests whether a daily D-Mannose drink mix (FLUSH) can help women with a history of recurrent UTIs have fewer infections and better urinary health. About 210 adult women will be randomly assigned to one of three groups. Researchers will track how long it takes for a UTI to return, symptom severity, and quality of life.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- D-Mannose drink mix
- What this could lead to
- If it works, this could offer a simple, non-antibiotic option to help women with recurrent UTIs reduce flare-ups and improve urinary health.
- What could go wrong
- This is a dietary supplement trial, not a drug study, so results may be modest. The supplement may not prevent infections better than placebo, and individual responses can vary.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 210 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jul 2025
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 75 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Healthy biological females who are 18-75 years of age (inclusive). 2. Have a history of recurrent uncomplicated UTI (≥2 UTIs in the last 6 months and/or ≥3 UTIs in the last 12 months). 3. Are within 7 days of the enrollment trigger event (acute UTI). 4. In good general health (no active or uncontrolled diseases or conditions besides recurrent UTIs) and able to consume the study product. 5. BMI 18.5-39.9 kg/m\^2 6. Have reliable, stable access to Wi-Fi and a smart phone/device. 7. Willing and able to agree to the requirements and restrictions of this study, willing to give voluntary consent, able to understand and read questionnaires, and able to carry out all study-related procedures. Exclusion Criteria: 1. Individuals who are lactating, pregnant, or planning to become pregnant during the study. 2. Active participation in a clinical trial. 3. Use of any treatment for menopausal outcomes or other concomitant treatments. 4. Have a known sensitivity, intolerability, or allergy to any of the study products or their excipients. 5. History of hyperkalemia (high potassium). 6. History of Chronic Kidney Disease. 7. Introduction of antibiotics unrelated to a UTI occurrence during the trial period. 8. Current use of D-mannose (participants may complete a 2-week washout period). 9. Has previously used the FLUSH product. 10. Current use of antibiotic-based prophylaxis. 11. History of Diabetes mellitus (Type 1 and/or 2). 12. Use of vaginal and/or local estrogen therapy (permitted if stable dose longer than 90 days). 13. Active or suspected vaginitis. 14. Started a new nonantibiotic-based prophylaxis within the last 90 days. 15. Use of probiotics (permitted if orally administered with stable dose longer than 90 days). 16. Use of indwelling or intermittent urinary catheterization. 17. Diagnosis of overactive bladder (OAB) or interstitial cystitis /bladder pain syndrome (IC/BPS). 18. Urologic procedure within 6 months prior to trial enrollment. 19. History of structural urinary tract disease. 20. History of Lichen sclerosis. 21. Use of potassium-sparing medications. o E.g., Spironolactone (used for PCOS) (potassium-sparing diuretic); ACE inhibitors and ARBs; systemic calcineurin inhibitors.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Bonafide Health
RECRUITINGHarrison, New York, 10528, United States