Can a simple drink mix keep UTIs away? new trial seeks answers

NCT ID NCT07453693

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This 6-month study tests whether a daily D-Mannose drink mix (FLUSH) can help women with a history of recurrent UTIs have fewer infections and better urinary health. About 210 adult women will be randomly assigned to one of three groups. Researchers will track how long it takes for a UTI to return, symptom severity, and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
D-Mannose drink mix
What this could lead to
If it works, this could offer a simple, non-antibiotic option to help women with recurrent UTIs reduce flare-ups and improve urinary health.
What could go wrong
This is a dietary supplement trial, not a drug study, so results may be modest. The supplement may not prevent infections better than placebo, and individual responses can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 210 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Healthy biological females who are 18-75 years of age (inclusive). 2. Have a history of recurrent uncomplicated UTI (≥2 UTIs in the last 6 months and/or ≥3 UTIs in the last 12 months). 3. Are within 7 days of the enrollment trigger event (acute UTI). 4. In good general health (no active or uncontrolled diseases or conditions besides recurrent UTIs) and able to consume the study product. 5. BMI 18.5-39.9 kg/m\^2 6. Have reliable, stable access to Wi-Fi and a smart phone/device. 7. Willing and able to agree to the requirements and restrictions of this study, willing to give voluntary consent, able to understand and read questionnaires, and able to carry out all study-related procedures. Exclusion Criteria: 1. Individuals who are lactating, pregnant, or planning to become pregnant during the study. 2. Active participation in a clinical trial. 3. Use of any treatment for menopausal outcomes or other concomitant treatments. 4. Have a known sensitivity, intolerability, or allergy to any of the study products or their excipients. 5. History of hyperkalemia (high potassium). 6. History of Chronic Kidney Disease. 7. Introduction of antibiotics unrelated to a UTI occurrence during the trial period. 8. Current use of D-mannose (participants may complete a 2-week washout period). 9. Has previously used the FLUSH product. 10. Current use of antibiotic-based prophylaxis. 11. History of Diabetes mellitus (Type 1 and/or 2). 12. Use of vaginal and/or local estrogen therapy (permitted if stable dose longer than 90 days). 13. Active or suspected vaginitis. 14. Started a new nonantibiotic-based prophylaxis within the last 90 days. 15. Use of probiotics (permitted if orally administered with stable dose longer than 90 days). 16. Use of indwelling or intermittent urinary catheterization. 17. Diagnosis of overactive bladder (OAB) or interstitial cystitis /bladder pain syndrome (IC/BPS). 18. Urologic procedure within 6 months prior to trial enrollment. 19. History of structural urinary tract disease. 20. History of Lichen sclerosis. 21. Use of potassium-sparing medications. o E.g., Spironolactone (used for PCOS) (potassium-sparing diuretic); ACE inhibitors and ARBs; systemic calcineurin inhibitors.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

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  3. A doctor treating you

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Contacts and locations

Locations

  • Bonafide Health

    RECRUITING

    Harrison, New York, 10528, United States