Could a common antibiotic slash deaths from brain TB?
NCT ID NCT06446245
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether adding the antibiotic doxycycline to standard treatment can reduce deaths and severe brain damage in adults with tuberculosis of the brain or its lining. About 200 participants will receive either doxycycline or a placebo for 8 weeks, alongside usual TB drugs and steroids. The study builds on earlier work showing doxycycline may calm harmful inflammation in TB.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
doxycycline
What this could lead to
If it works, this could point toward a cheap, widely available add-on treatment to lower the high death and disability rates from brain tuberculosis.
What could go wrong
This is a mid-stage trial with only 200 participants, so results may not apply to everyone. Doxycycline can cause side effects like sun sensitivity and stomach upset.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Adam Malik Hospital
RECRUITINGMedan, Medan, Indonesia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Murni Teguh Memorial Hospital
RECRUITINGMedan, Indonesia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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National University Hospital
RECRUITINGSingapore, Singapore, 119228, Singapore
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sarawak General Hospital
NOT_YET_RECRUITINGKuching, Sarawak, Malaysia
Contact Email: •••••@•••••
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Tan Tock Seng Hospital
RECRUITINGSingapore, Singapore
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitas Sumatera Utara
RECRUITINGMedan, Medan, Indonesia
Contact Phone: •••-•••-•••• Email: •••••@•••••