New antibiotic combo aims to cut treatment time for stubborn lung infection

NCT ID NCT07213765

Recruiting now Disease control Sponsor: Bin Cao Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding the antibiotic contezolid to standard drugs can shorten treatment for Mycobacterium Avium Complex (MAC) lung disease. About 188 adults with the nodular bronchiectatic form of the disease will either receive contezolid plus standard therapy for 6 months, or standard therapy alone for 12 months. Researchers will check if the combination leads to faster clearance of bacteria and better quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Contezolid (an antibiotic) added to a standard regimen of azithromycin, ethambutol, and rifampicin
What this could lead to: If it works, this could lead to a shorter, more effective treatment for MAC lung disease, reducing the time patients need to take antibiotics.
What could go wrong: This is a Phase 4 trial with 188 participants, so results are not yet proven. Adding a new drug may cause side effects or not improve outcomes compared to standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Mycobacterium avium complex disease pulmonary non-tuberculous mycobacterial infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYCOBACTERIUM AVIUM COMPLEX PULMONARY DISEASE

Contacts and locations

Locations

Anhui Chest Hospital
RECRUITING

Hefei, Anhui, China
Beijing Chest Hospital, Capital Medical University
RECRUITING

Beijing, Beijing Municipality, China
China-Japan Friendship Hospital
RECRUITING

Beijing, Beijing Municipality, China
Guangzhou Chest Hospital
NOT_YET_RECRUITING

Guangzhou, Guangdong, China
Jiangxi Chest Hospital
RECRUITING

Nanchang, Jiangxi, China
Shanghai Pulmonary Hospital
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, China

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