New pill aims to stop hearing loss from lifesaving antibiotics
NCT ID NCT05730283
First seen Jun 27, 2026 · Last updated Jul 15, 2026 · Updated 4 times
Summary
This study tests whether the drug ORC-13661 can prevent hearing loss in people receiving intravenous amikacin for a lung infection called NTM. About 105 adults will take either a high dose, low dose, or placebo daily for up to 90 days. Researchers will compare hearing changes among the groups to see if the drug helps.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ORC-13661
- What this could lead to
- If it works, this could lead to a way to protect hearing in patients who need strong antibiotics like amikacin.
- What could go wrong
- This is a Phase 2 trial with only 105 people, so results may not apply to everyone. The drug might not prevent hearing loss better than a placebo.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Locations
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Johns Hopkins University
RECRUITINGBaltimore, Maryland, 21224, United States
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29425, United States
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National Jewish Health
RECRUITINGDenver, Colorado, 80206, United States
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Northwell Health
RECRUITINGManhasset, New York, 11030, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Oregon Health & Science University
RECRUITINGPortland, Oregon, 97239, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California, San Francisco
RECRUITINGSan Francisco, California, 94143, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Texas Health Science Center
RECRUITINGTyler, Texas, 75708, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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