Hope for cancer patients: drug may shield ears from chemo damage

NCT ID NCT07364747

Recruiting now Prevention Sponsor: Siriraj Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether acetylcysteine, a drug often used for other purposes, can prevent hearing loss caused by cisplatin chemotherapy. About 40 adults receiving high-dose cisplatin will get either acetylcysteine or a placebo after each chemo session. Researchers will measure hearing changes over time to see if the drug offers protection.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: acetylcysteine (N-acetylcysteine)
What this could lead to: If it works, this could offer a simple way to prevent permanent hearing loss in patients receiving cisplatin chemotherapy.
What could go wrong: This is a small, early-phase trial with only 40 participants. The results may not apply to all patients, and acetylcysteine might not provide significant protection or could have side effects.

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Conditions

The condition(s) this trial relates to.

Hearing Loss, Sensorineural Ototoxicity sensorineural hearing loss disorder toxic labyrinthitis X-linked mixed hearing loss with perilymphatic gusher platinum-induced ototoxicity prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CISPLATIN-INDUCED OTOTOXICITY OTOTOXICITY OTOTOXICITY, DRUG-INDUCED SENSORINEURAL HEARING LOSS

Contacts and locations

Locations

Faculty of Medicine Siriraj Hospital, Mahidol University
RECRUITING

Bangkok, Bangkoknoi, 10700, Thailand

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