Hope for cancer patients: drug may shield ears from chemo damage

NCT ID NCT07364747

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether acetylcysteine, a drug often used for other purposes, can prevent hearing loss caused by cisplatin chemotherapy. About 40 adults receiving high-dose cisplatin will get either acetylcysteine or a placebo after each chemo session. Researchers will measure hearing changes over time to see if the drug offers protection.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

acetylcysteine (N-acetylcysteine)

What this could lead to

If it works, this could offer a simple way to prevent permanent hearing loss in patients receiving cisplatin chemotherapy.

What could go wrong

This is a small, early-phase trial with only 40 participants. The results may not apply to all patients, and acetylcysteine might not provide significant protection or could have side effects.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Hearing Loss, Sensorineural Ototoxicity sensorineural hearing loss disorder toxic labyrinthitis X-linked mixed hearing loss with perilymphatic gusher platinum-induced ototoxicity prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Faculty of Medicine Siriraj Hospital, Mahidol University

    RECRUITING

    Bangkok, Bangkoknoi, 10700, Thailand

    Contact Phone: •••-•••-•••• Email: •••••@•••••