Sensorineural hearing loss disorder

This study tests whether programming a cochlear implant based on each person's unique inner ear structure improves hearing compared to the standard one-size-fits-all approach. Adults with severe to profound hearing loss who already have a MED-EL cochlear implant will receive both…

This phase 2 trial tests whether the drug SPI-1005 can prevent hearing loss and reduce side effects like tinnitus and vertigo in adults receiving a cochlear implant. Forty participants will take either the drug or a placebo for 6 months, starting 2 days before surgery. The study …

This study is testing a new type of cochlear implant that is completely hidden under the skin, with no visible parts outside the ear. It is for adults with severe hearing loss due to inner ear or nerve damage. The goal is to see if the implant helps people understand speech bette…

This trial tests an investigational drug called DX243 in people with mild to moderate age-related hearing loss. Participants receive daily injections of DX243 or a placebo for 29 days. The study checks whether the drug is safe and whether it improves hearing, using speech-in-nois…

This study tests an experimental device called the Tinnitus Implant System for adults with moderate to severe chronic tinnitus. The implant is placed behind the ear and sends electrical signals to the hearing nerve. Researchers will measure how much tinnitus loudness changes over…

This study tests whether a single injection of dexamethasone-loaded exosomes into the ear can improve hearing recovery better than standard steroid injections in adults with sudden sensorineural hearing loss. About 30 participants who did not improve with oral steroids will be ra…

This study tests whether placing a cochlear implant's ground electrode near the vagus nerve behind the ear works as well as the standard placement under a muscle. Twelve adults getting a cochlear implant will participate. The main goal is to see if speech understanding in noise i…

This study tests whether Yiyuancong, a traditional Chinese medicine made from food-like ingredients, can help people with sudden hearing loss. About 128 adults aged 18-60 will take the formula for 1-2 months, and their hearing will be measured with standard tests. The goal is to …

This trial tests a gene therapy called AAVAnc80-hOTOF for people with severe hearing loss caused by mutations in the otoferlin gene. The therapy is given as a single injection into the inner ear during surgery. The study will check if the treatment is safe and if it can improve h…

This study follows 300 deaf patients of all ages who receive cochlear implants, tracking their hearing, speech, and quality of life over time. Researchers aim to see how different age groups and treatment types respond, to personalize rehabilitation. Participants must have severe…

This study tests whether using a real-time hearing monitoring technique called ECochG during cochlear implant surgery helps preserve natural hearing and inner ear structure better than standard surgery. About 102 adults with severe-to-profound hearing loss will be randomly assign…

This study tests an auditory brainstem implant in 20 children who are deaf because they are missing the inner ear or the nerve that carries sound to the brain. The device is surgically placed to stimulate the brainstem directly, bypassing the missing parts. Researchers will monit…

This study looks at how well cochlear implants work over three years for people with single-sided deafness or asymmetric hearing loss. Participants receive a cochlear implant system to help them hear better in noisy situations. The goal is to confirm long-term safety and effectiv…

This study compares two common hearing screening methods—pure-tone audiometry and otoacoustic emissions—in over 13,000 preschool children. The goal is to determine which method is better at identifying hearing loss early, so children can get the help they need to avoid speech and…

This study aims to create a step-by-step guide for adapting a children's speech hearing test, called MATCH, into different languages. Researchers will test the adapted test on 120 children, including those with normal hearing and those with hearing loss, to make sure it works cor…

This study tests whether acetylcysteine, a drug often used for other purposes, can prevent hearing loss caused by cisplatin chemotherapy. About 40 adults receiving high-dose cisplatin will get either acetylcysteine or a placebo after each chemo session. Researchers will measure h…

This study tests whether injecting a special gel (sodium thiosulfate) into the ear before each round of cisplatin chemotherapy can prevent hearing loss. About 100 adults with head and neck cancer will receive the gel in one ear only, so the treated ear can be compared to the untr…

This study is testing whether changing the frequency settings on a cochlear implant can improve sound quality and speech understanding for people who use both a cochlear implant and a hearing aid. Thirteen experienced bimodal users will try an experimental frequency setting for o…

This study tests a new hearing aid device (RH210A) in 24 adults with self-perceived mild-to-moderate hearing loss. Participants will compare the investigational device to Apple AirPods Pro with a hearing aid feature. The goal is to see if the new device improves hearing and speec…

This study tests a new Bluetooth Low Energy Audio feature in Nucleus 8 and Kanso 3 sound processors for cochlear implants. Twenty experienced adult users will try wireless microphones at home and in the lab to see if they can hear speech better in noisy places like classrooms. Th…

This study tests whether Apple AirPods can help adults with mild-to-moderate hearing loss understand speech in noisy places. Twenty-four participants will compare AirPods, hearing aids, and wireless microphones in a single lab session. Researchers will measure how well people hea…

This study tests whether adding acupuncture to standard steroid treatment helps people recover hearing after sudden sensorineural hearing loss. 256 adults will receive either real or sham acupuncture three times a week for four weeks, along with oral steroids. The main goal is to…

This study compares two ways of tuning cochlear implants to see which helps adults with hearing loss understand speech better, especially in noisy settings. About 25 French-speaking adults who have had a cochlear implant for six months will try both settings. The goal is to find …

This study compares two methods for tuning cochlear implants: a standard tonotopic-based setting (FS4T) and a new setting adjusted by an evolutionary algorithm (EAFS4T). Researchers want to see which one helps 22 adults with hearing loss understand speech better, especially in no…

This study compares 3D-printed ear tips to standard ones for hearing aids in 32 adults with hearing loss. Participants will try each type for a week and rate comfort, sound quality, and fit. Researchers will also measure production time and cost to see if 3D printing is a practic…

This study is testing whether changing the low-frequency settings on a cochlear implant can improve hearing for people who are deaf in one ear but have normal hearing in the other. Twenty-two adults will try four different sound maps during their first month after implant activat…

This study tests whether a one-month treatment combining the allergy drug clemastine fumarate with engineered sound can improve the ability to hear speech in background noise for people aged 45-65 with age-related central auditory processing disorder (CAPD). About 344 participant…

This study tests a new way for hearing aids to process soft sounds, aiming to make quiet speech clearer. Sixteen adults with hearing loss will try two different hearing aid settings in a lab and rate which one sounds more natural and understandable. The goal is to improve hearing…

This study tests whether automatic sound processing in cochlear implants helps children with hearing loss understand speech in noisy environments. Twenty children aged 6 to 16 who use cochlear implants will compare three different sound settings. The goal is to see which setting …

This trial tests whether a set of three virtual-reality games, called BEARS, can improve hearing in noisy places for children aged 8 to 16 who have two cochlear implants. The games train the brain to pick out speech from background noise, locate where sounds come from, and enjoy …

This study tests whether a new AI-based noise reduction feature in Phonak hearing aids helps people with hearing loss or cochlear implants hear speech more clearly in noisy settings. Researchers will measure how well 500 participants repeat words and sentences in quiet and noisy …

This study looks at whether combining a non-invasive brain stimulation technique called rTMS with hearing aids can improve cognitive function in older adults with age-related hearing loss. About 189 participants, including those with and without hearing aids, will receive two 14-…

This study compares two ways of tuning cochlear implants for people who also use a hearing aid in the other ear. The new method aims to match the implant's sound processing to the natural pitch map of the ear. Twenty adults with hearing loss will try both tuning methods to see wh…

This study compares two fitting methods for people who use a cochlear implant in one ear and a hearing aid in the other. One method synchronizes the devices, the other does not. Researchers want to see if synchronization helps with sound localization and speech understanding in n…

This pilot study tests whether a new training program called SEBAR can improve confidence and success with over-the-counter (OTC) hearing aids. Twenty-seven adults with mild-to-moderate hearing loss who have never used hearing aids will wear OTC devices for a week and answer ques…

This study is testing a new software algorithm called SEDA that reduces background noise for cochlear implant users. Researchers will measure how well 60 participants (ages 12 and older) understand speech in quiet and noisy settings with and without the algorithm. The goal is to …

This study tests a new noise-reduction feature for hearing aids that uses deep neural networks to help people hear speech better in noisy settings. Fifty adults with mild-to-moderate hearing loss will listen to sentences at different noise levels while using three settings: no no…

This study tests whether a gentle electrical stimulation on the ear (taVNS) can improve speech understanding in noisy environments for older adults with age-related hearing loss. 36 participants aged 55-80 will receive either active or sham stimulation. The goal is to see if this…

This study tests a new hearing aid, Audiocap, in 100 adults with mild-to-moderate hearing loss who have never used a hearing aid before. The goal is to see if it improves hearing better than a placebo device after one month of use. Participants will undergo standard hearing tests…

This study tests whether six months of music therapy, starting right after cochlear implant surgery, can improve a person's ability to understand speech in noisy places. Thirty adults who speak German will be split into groups: some start music therapy immediately, some start lat…

This study compares using virtual reality glasses versus the standard 'show-do' technique to reduce dental anxiety in 54 children with moderate to severe hearing impairment. The children will have their pulse and anxiety scores measured during a dental cleaning. The goal is to se…

This study tests whether adding traditional Chinese medicine and acupuncture to standard Western treatment helps people with sudden hearing loss recover faster and feel better. Researchers will compare standard care alone versus combined treatment in 64 adults who recently lost h…

This study looks at whether stimulating deeper parts of the inner ear with a cochlear implant helps people hear music better. About 32 adults with hearing loss who already qualify for a cochlear implant will test two different stimulation depths. The goal is to see if the deeper …

This study tests three hearing aid adjustments to help people with hearing loss understand speech in noisy, multi-talker settings. Researchers will compare how well 220 participants (with normal hearing or hearing loss) can pick out words and sense where sounds come from, with an…

This study is testing whether joining a choir for 12 weeks can help older adults (60+) with mild-to-moderate untreated hearing loss understand speech better and improve their mood and social connections. 210 participants will be randomly assigned to either a weekly group singing …

This study tests whether community healthcare workers can effectively fit hearing aids using a smartphone app in low- and middle-income communities. 90 adults with mild to severe hearing loss will be randomly assigned to receive either a smartphone-based fitting, a pre-set fittin…

This study investigates whether brain imaging can predict how well children with cochlear implants will develop language skills. Researchers are building models to forecast long-term language outcomes in English- and Spanish-speaking children. They are also testing a parent-led c…

This study investigates whether older adults with age-related hearing loss (presbycusis) can still hear and enjoy the sound of a crunchy biscuit while eating. Researchers will compare a crunchy biscuit with a soft one in 100 seniors aged 65 and older, asking them if they hear the…

This study looks at whether listening to music with a steady beat can improve how older adults with age-related hearing loss process sentences. Researchers will have 55 participants aged 70 or older listen to regular or irregular rhythm music, then judge if sentences are grammati…

This study looks at why some people aged 60 and older have trouble understanding speech in noisy settings, even though their standard hearing tests are normal. Researchers will use hearing tests and brain scans to see if the problem is related to how the brain processes sound tim…

This study analyzes dried blood spots from 630 newborns to find protein and RNA markers that could predict which babies with congenital CMV will develop hearing loss or other problems. Researchers will compare samples from infected babies who had complications, those who did not,…

This study will follow 5,000 children and teens with hearing loss and normal hearing over time. Researchers will measure changes in hearing, speech, language, and brain scans to see how different treatments—like hearing aids, cochlear implants, or gene therapy—affect development.…

This study follows 180 children up to age 16 who have hearing loss caused by mutations in the GJB2 or OTOF genes. Researchers will regularly measure their hearing using standard tests and questionnaires to see how it changes over time. The goal is to better understand the natural…

This study looks at how people with normal hearing, hearing loss, or cochlear implants use nearby sounds to recognize speech. Researchers will test participants' ability to identify words and sentences in quiet and noisy settings. The goal is to better understand how hearing aids…

This study looks at whether programming a cochlear implant from home works as well as doing it in the clinic. About 51 adults with hearing loss will have their device adjusted both remotely and in-office to compare hearing test results. The goal is to see if remote programming is…

This study looks at whether people with new cochlear implants can have fewer follow-up appointments and still get good results. Researchers will test a new programming method that may make each visit shorter. About 48 adults who are getting a Cochlear Americas implant will take p…

This study uses PET scans to watch brain activity while people with cochlear implants try to understand speech in background noise. Researchers want to pinpoint which brain regions help make sense of sound in challenging listening situations. The study includes 120 cochlear impla…

This study looks at adults aged 30 to 55 who have hearing loss that started after age 16 and carry a mutation in the GJB2 gene. Researchers will track how their hearing changes over time using hearing tests and genetic analysis. The goal is to better understand this form of heari…

This study tests a patient navigation program to help rural adults in Kentucky get hearing tests. 500 participants from primary care clinics will receive guidance every two weeks to overcome barriers like travel and cost. The goal is to see if more people complete diagnostic hear…

This study looks at whether simpler hearing aid settings work better for older adults with Alzheimer's dementia or mild memory problems. Researchers will test two different hearing aid programs in 20 participants to see which one helps them understand speech in noisy settings and…

This observational study looks at how much mental energy children aged 6-18 with cochlear implants use when listening, and whether that extra effort slows their brain development over three years. Researchers will compare 240 children with cochlear implants to 120 children with n…

This study looks at how people with hearing aids perceive the timbre (quality) of sounds and understand complex sound scenes, like music or crowded rooms. Researchers will compare 75 adults aged 60-75 with and without hearing loss. Participants will listen to sounds and rate how …

This study follows up to 150 people with hearing loss caused by changes in the otoferlin gene. Researchers will measure hearing function using tests like auditory brainstem response (ABR) and otoacoustic emissions (OAE). The goal is to learn how this type of hearing loss changes …

This study aims to improve how children with cochlear implants perceive sound by testing new sound coding strategies. Researchers will compare hearing performance between children and adults, and between those with implants and those with normal hearing. The goal is to understand…

This study aims to find out why hearing aids work well in quiet labs but not in noisy real-world settings. About 45 adults with hearing loss who already use hearing aids will listen to different sound scenarios and rate their experience. The goal is to improve hearing aid perform…

This nationwide study aims to understand how hearing loss affects thinking, language, reading, and emotional wellbeing in 256 deaf or hard-of-hearing adolescents. Researchers will use tests and questionnaires to measure speech perception, cognitive skills, and school burnout. No …

This study is gathering information from 100 children and adults who use MED-EL hearing devices, including implants and non-implantable devices. Researchers will collect data on hearing ability, speech understanding, and quality of life through tests and questionnaires. The goal …

This study aims to understand why people with Turner syndrome often lose their hearing. Researchers will look at genetic and epigenetic markers in 150 adults aged 18-60. Participants will have hearing, balance, blood, and imaging tests. The goal is to find new ways to treat or de…

This study observes how children and adults with hearing loss who use cochlear implants and preserve some natural hearing process sound, especially in noisy settings. Researchers will measure hearing abilities over time in 200 participants, including those with normal hearing for…

This study collects information from 450 newborns who fail their initial hearing screening. Doctors will test them for congenital CMV, a common infection that can cause hearing loss and other problems. The goal is to see how often CMV is found and to improve follow-up care for af…

This research study looks at how children and adults who use cochlear implants or auditory brainstem implants hear and understand sounds. Participants will listen to words, sentences, and tones to see how well they identify speech and tell differences in loudness or pitch. The go…

This study explores whether a brain-scanning technique called fNIRS can measure how well hearing aids help young children with hearing loss. Researchers will compare brain activity in 40 infants (3-18 months old) with normal hearing and those using hearing aids. If fNIRS proves r…

This study looks at whether inner-ear balance (vestibular) problems make reading harder for children with hearing loss. Researchers will test 90 children, some with normal hearing and some with severe hearing loss, measuring their ability to see clearly during head movements and …

This study looks at how older adults with hearing loss understand speech in noisy settings, and how hearing aids can help. Researchers will test 121 people, including young and older adults with normal hearing and older adults with hearing loss. They will measure both behavior (l…

This study follows 19 adults with hearing loss who already received a cochlear implant that releases a steroid to reduce inflammation. Researchers will check how well the implant works over 5 years by measuring electrical signals and tracking any side effects. The goal is to see …

This study looks at how people with cochlear implants understand speech in everyday situations, like conversations with background noise. Researchers will test 460 adults (both with and without hearing loss) using listening tasks that measure effort and comprehension. The goal is…

This study explores whether a test that measures brain waves in response to visual images can be used in a new way for people with hearing loss. Researchers will compare these brain responses to standard hearing tests and thinking skills tests. The goal is to see if this test can…

This study looks at how children and adults with cochlear implants and some natural hearing understand speech in noisy environments and locate where sounds come from. Researchers will test 160 participants, including those with normal hearing and those with cochlear implants. The…

This study looks at how children and adults with cochlear implants understand and express emotions through speech. Researchers will measure how well participants recognize emotions in voices and how they produce emotional sounds. The goal is to find out why some implant users str…

This study tests whether a special monitoring tool called electrocochleography can help surgeons preserve a patient's remaining natural hearing while placing a cochlear implant. About 40 adults with severe hearing loss in both ears will be randomly assigned to receive the monitor…