Auditory system disorder

This study tests a new gene therapy called DB-OTO for children with hearing loss caused by changes in the otoferlin gene. The treatment is injected into the inner ear to help restore hearing. Up to 30 children and infants will take part to check safety and how well it works.

This study tests a new whole-cell pneumococcal vaccine (wSp) in healthy children aged around 7 to 9 months who already received standard pneumonia vaccines. The goal is to see if wSp reduces pneumococcal bacteria in the nose and boosts immune protection. Researchers will compare …

This study tests whether programming a cochlear implant based on each person's unique inner ear structure improves hearing compared to the standard one-size-fits-all approach. Adults with severe to profound hearing loss who already have a MED-EL cochlear implant will receive both…

This study tests whether rimegepant, a dissolving tablet, can prevent migraines in children and adolescents ages 6 to under 18. About 640 participants will receive either the drug or a placebo for 12 weeks. The main goal is to see if the drug reduces the number of migraine days p…

This early-stage trial tests a new gene therapy called SKY-GJB2 for children aged 9 months to 7 years with hearing loss caused by changes in the GJB2 gene. The therapy is given as a single injection into the inner ear using a special delivery device. The study will enroll 10 chil…

This study is testing whether a cochlear implant is safe and effective for infants and toddlers who are deaf in one ear. Sixty children will receive the implant and be followed until age 5. Researchers will compare their hearing abilities to children with normal hearing and to th…

This phase 2 trial tests whether the drug SPI-1005 can prevent hearing loss and reduce side effects like tinnitus and vertigo in adults receiving a cochlear implant. Forty participants will take either the drug or a placebo for 6 months, starting 2 days before surgery. The study …

This study is testing a new type of cochlear implant that is completely hidden under the skin, with no visible parts outside the ear. It is for adults with severe hearing loss due to inner ear or nerve damage. The goal is to see if the implant helps people understand speech bette…

This study tests an experimental drug called REGN5093 in people with advanced non-small cell lung cancer that has a specific change in the MET gene. The first part finds a safe dose, and the second part checks if the drug can shrink tumors. About 231 participants will take part.

This trial tests an investigational drug called DX243 in people with mild to moderate age-related hearing loss. Participants receive daily injections of DX243 or a placebo for 29 days. The study checks whether the drug is safe and whether it improves hearing, using speech-in-nois…

This study tests a drug called SPI-1005 in 200 adults with Meniere's disease, a condition that causes hearing loss, ringing in the ears, and dizziness. Participants will take the drug twice a day for 6 or 12 months to see if it is safe and tolerable. The goal is to find a treatme…

This study tests an experimental device called the Tinnitus Implant System for adults with moderate to severe chronic tinnitus. The implant is placed behind the ear and sends electrical signals to the hearing nerve. Researchers will measure how much tinnitus loudness changes over…

This study tests whether a single injection of dexamethasone-loaded exosomes into the ear can improve hearing recovery better than standard steroid injections in adults with sudden sensorineural hearing loss. About 30 participants who did not improve with oral steroids will be ra…

This study tests whether placing a cochlear implant's ground electrode near the vagus nerve behind the ear works as well as the standard placement under a muscle. Twelve adults getting a cochlear implant will participate. The main goal is to see if speech understanding in noise i…

This study tests whether bisphosphonates, drugs commonly used to strengthen bones, can also treat hearing loss in people with Osteogenesis Imperfecta (OI) type I. Researchers will enroll 100 adults and children with OI, giving some the drug and comparing their hearing over time. …

This phase 2 trial tests whether anakinra (Kineret), an anti-inflammatory drug, can improve hearing in people with Meniere's disease or autoimmune inner ear disease who cannot take steroids. About 57 participants will receive daily injections of anakinra or a placebo for 42 days,…

This trial tests a gene therapy called EHT102 for children with congenital hearing loss caused by mutations in the OTOF gene. Up to 30 children will receive a single injection in one ear to see if it safely improves hearing. The study is early-stage, focusing on safety and whethe…

This early-stage trial tests a gene therapy given as a single injection into the inner ear for people with a non-cancerous tumor called vestibular schwannoma. The therapy uses a harmless virus to deliver a gene that blocks blood vessel growth to the tumor, potentially stopping it…

This study tests whether Yiyuancong, a traditional Chinese medicine made from food-like ingredients, can help people with sudden hearing loss. About 128 adults aged 18-60 will take the formula for 1-2 months, and their hearing will be measured with standard tests. The goal is to …

This study follows 15 adults (ages 22–90) with severe, long-term balance disorders caused by inner ear damage. Participants have already received a vestibular implant, a device that electrically stimulates the balance nerve to help restore steadiness and clear vision during movem…

This trial tests a gene therapy called AAVAnc80-hOTOF for people with severe hearing loss caused by mutations in the otoferlin gene. The therapy is given as a single injection into the inner ear during surgery. The study will check if the treatment is safe and if it can improve h…

This early-stage trial tests whether a substance called VSF1.01, made from stem cell secretions, can safely reduce trauma to the inner ear during cochlear implant surgery. Eleven adults with severe hearing loss will receive the treatment directly into the cochlea before the impla…

This study follows 300 deaf patients of all ages who receive cochlear implants, tracking their hearing, speech, and quality of life over time. Researchers aim to see how different age groups and treatment types respond, to personalize rehabilitation. Participants must have severe…

This study is testing a new, flexible hearing aid that sticks to the skin behind the ear or on the forehead. It is designed for people with conductive hearing loss, where sound doesn't travel properly to the inner ear. The trial will include 200 children and adults to see if the …

This phase 2 trial is testing whether giving the immunotherapy drug tislelizumab along with chemotherapy before surgery can shrink advanced squamous cell carcinoma of the ear canal. The goal is to make surgery easier and safer, especially to protect important nerves near the ear.…

This study tests a vestibular implant in 15 older adults (ages 65-90) with chronic balance issues due to bilateral vestibular hypofunction. The implant electrically stimulates the inner ear to improve balance and vision. Researchers will measure changes in gait and eye reflexes o…

This study tests the Sentio bone-anchored hearing system in 50 children aged 3 to 11 with hearing loss or single-sided deafness. The device is already approved for older kids and adults. Researchers want to see if it safely improves hearing compared to no aid. The trial is happen…

This study tests a vestibular implant, a device surgically placed in the inner ear to electrically stimulate balance nerves. It aims to improve balance, posture, and vision in up to 8 adults with bilateral vestibular hypofunction, a condition causing chronic dizziness and instabi…

This study tests whether using a real-time hearing monitoring technique called ECochG during cochlear implant surgery helps preserve natural hearing and inner ear structure better than standard surgery. About 102 adults with severe-to-profound hearing loss will be randomly assign…

This study is testing an experimental device called a vestibular implant, which is surgically placed behind the ear to stimulate the balance nerve. The goal is to see if it can improve walking and balance in adults with long-term dizziness that hasn't improved with other treatmen…

This study tests an auditory brainstem implant in 20 children who are deaf because they are missing the inner ear or the nerve that carries sound to the brain. The device is surgically placed to stimulate the brainstem directly, bypassing the missing parts. Researchers will monit…

This study looks at how well cochlear implants work over three years for people with single-sided deafness or asymmetric hearing loss. Participants receive a cochlear implant system to help them hear better in noisy situations. The goal is to confirm long-term safety and effectiv…

This study is testing the Sentio system, a bone-anchored hearing device, in 25 adolescents aged 12 to 17 with conductive or mixed hearing loss or single-sided deafness. The goal is to see if the device safely improves hearing on the implanted ear. Participants will be followed to…

This study tests the drug belzutifan in 100 people with von Hippel-Lindau (VHL) syndrome, a genetic condition that causes tumors in various organs. Researchers will track how well the drug shrinks tumors and how long it takes for the disease to progress, while also monitoring sid…

This study looks at two methods to help doctors prescribe fewer antibiotics for children with ear infections when they aren't needed. One method uses changes to electronic health records and feedback reports for doctors. The other adds a shared decision-making tool that involves …

This study tests a program that brings hearing screening and ear check-ups to children in rural Kentucky schools using mobile health tools and video doctor visits. The goal is to see if more children get screened and receive follow-up care compared to usual school screenings. Abo…

This study is testing a device called Wideband Tympanometry to see if it can measure how well the middle ear conducts speech without requiring the patient to respond. Researchers will compare these measurements with standard speech tests in 45 adults with normal hearing or conduc…

This study tests a new device that uses artificial intelligence to help diagnose ear infections, strep throat, and asthma flare-ups in children. About 84 kids aged 3 to 17 will either use the device at home with a doctor's video visit or receive standard in-person care. The goal …

This study tests a new device that uses special lights to look at the eardrum and detect fluid behind it, which is a sign of middle ear infection. The goal is to make diagnosis more accurate than current methods. The study will include 150 people of all ages who are scheduled for…

This study compares two common hearing screening methods—pure-tone audiometry and otoacoustic emissions—in over 13,000 preschool children. The goal is to determine which method is better at identifying hearing loss early, so children can get the help they need to avoid speech and…

This study aims to create a step-by-step guide for adapting a children's speech hearing test, called MATCH, into different languages. Researchers will test the adapted test on 120 children, including those with normal hearing and those with hearing loss, to make sure it works cor…

This study tests whether a new imaging technology called optical coherence tomography (OCT) can help doctors more accurately diagnose ear infections in children. Researchers will compare standard ear exams with OCT-enhanced exams in 235 children. The goal is to see if OCT reduces…

This study tests whether an AI-powered app can help doctors more accurately diagnose ear infections in young children (6-24 months) with cold symptoms. Researchers will compare standard ear exams with the AI app's analysis of eardrum photos. The goal is to see if the AI reduces u…

This study tests whether the drug ORC-13661 can prevent hearing loss in people receiving intravenous amikacin for a lung infection called NTM. About 105 adults will take either a high dose, low dose, or placebo daily for up to 90 days. Researchers will compare hearing changes amo…

This study tests whether a program called HoorToren can help 10-11 year olds use headphones and earbuds more safely. About 600 children and their parents will take part, with half receiving the lessons and home assignments. Researchers will measure listening habits through survey…

This study tests whether acetylcysteine, a drug often used for other purposes, can prevent hearing loss caused by cisplatin chemotherapy. About 40 adults receiving high-dose cisplatin will get either acetylcysteine or a placebo after each chemo session. Researchers will measure h…

This study tests whether injecting a special gel (sodium thiosulfate) into the ear before each round of cisplatin chemotherapy can prevent hearing loss. About 100 adults with head and neck cancer will receive the gel in one ear only, so the treated ear can be compared to the untr…

This study tests the long-term safety of rimegepant, a migraine medication taken as a dissolving tablet, in children and adolescents aged 6 to 18. About 600 participants with a history of migraine will take the drug as needed for up to one year. The main goal is to check for side…

This study tests whether rimegepant, a fast-dissolving tablet, can safely relieve migraine pain in children and adolescents aged 6 to 18. About 2,100 participants will receive either the drug or a placebo during a migraine attack. The main goal is to see if more kids become pain-…

This study tests a new treatment called ACTIVE that combines counseling (Acceptance and Commitment Therapy) with balance exercises for people with mild traumatic brain injury. Researchers want to see if it helps reduce dizziness and anxiety better than standard balance therapy al…

This study is testing whether changing the frequency settings on a cochlear implant can improve sound quality and speech understanding for people who use both a cochlear implant and a hearing aid. Thirteen experienced bimodal users will try an experimental frequency setting for o…

This study tests a small, TENS-like device that sends a mild electric signal to improve balance and walking in older adults. Researchers will measure walking speed and stability in 120 participants aged 60 and older, as well as younger adults for comparison. Participants will wal…

This study tests whether a combination of two existing drugs, nortriptyline and topiramate, can reduce vertigo and other symptoms in people with Meniere's disease. Forty adults with active Meniere's will take the drugs or a placebo for 8 weeks. The goal is to see if this approach…

This study tests a drug called Pedmark (sodium thiosulfate) to see if it can prevent hearing loss in adults receiving cisplatin chemotherapy for cancers like testicular, head and neck, or thoracic cancer. About 25 adults will take Pedmark alongside their chemo. The drug is alread…

This study tests whether combining sound therapy with mild electrical stimulation inside the ear can reduce or temporarily stop tinnitus (ringing in the ears). Researchers will enroll 100 adults who have had tinnitus for at least 6 months. Participants will listen to sounds and r…

This study tests whether atorvastatin, a widely used cholesterol medication, can reduce hearing loss caused by cisplatin chemotherapy in people with head and neck cancer. About 224 adults will be randomly assigned to take atorvastatin or a placebo daily during and for three month…

This study tests a new hearing aid device (RH210A) in 24 adults with self-perceived mild-to-moderate hearing loss. Participants will compare the investigational device to Apple AirPods Pro with a hearing aid feature. The goal is to see if the new device improves hearing and speec…

This study tests a new Bluetooth Low Energy Audio feature in Nucleus 8 and Kanso 3 sound processors for cochlear implants. Twenty experienced adult users will try wireless microphones at home and in the lab to see if they can hear speech better in noisy places like classrooms. Th…

This study tests whether walking backwards, with or without a Bosu ball, can improve balance and mobility in children aged 8-12 with hearing loss. Twenty-four participants will be split into two groups: one doing only retro walking, the other adding Bosu ball exercises. Over 8 we…

This study tests whether a simple head-and-body movement called the Epley maneuver can quickly relieve dizziness from benign paroxysmal positional vertigo (BPPV) in the emergency department. About 118 adults with BPPV will either get the real maneuver or a fake one. Researchers w…

This study tests whether Apple AirPods can help adults with mild-to-moderate hearing loss understand speech in noisy places. Twenty-four participants will compare AirPods, hearing aids, and wireless microphones in a single lab session. Researchers will measure how well people hea…

This study tests whether adding acupuncture to standard steroid treatment helps people recover hearing after sudden sensorineural hearing loss. 256 adults will receive either real or sham acupuncture three times a week for four weeks, along with oral steroids. The main goal is to…

This study compares two ways of tuning cochlear implants to see which helps adults with hearing loss understand speech better, especially in noisy settings. About 25 French-speaking adults who have had a cochlear implant for six months will try both settings. The goal is to find …

This study compares two methods for tuning cochlear implants: a standard tonotopic-based setting (FS4T) and a new setting adjusted by an evolutionary algorithm (EAFS4T). Researchers want to see which one helps 22 adults with hearing loss understand speech better, especially in no…

This study compares 3D-printed ear tips to standard ones for hearing aids in 32 adults with hearing loss. Participants will try each type for a week and rate comfort, sound quality, and fit. Researchers will also measure production time and cost to see if 3D printing is a practic…

This study is testing whether changing the low-frequency settings on a cochlear implant can improve hearing for people who are deaf in one ear but have normal hearing in the other. Twenty-two adults will try four different sound maps during their first month after implant activat…

This study tests whether a one-month treatment combining the allergy drug clemastine fumarate with engineered sound can improve the ability to hear speech in background noise for people aged 45-65 with age-related central auditory processing disorder (CAPD). About 344 participant…

This study tests a new way for hearing aids to process soft sounds, aiming to make quiet speech clearer. Sixteen adults with hearing loss will try two different hearing aid settings in a lab and rate which one sounds more natural and understandable. The goal is to improve hearing…

This study compares black seed (Nigella sativa) oil to standard steroid ear drops for treating eczema in the ear canal. 85 adults with ear eczema will use either the oil or steroid drops twice daily for 10 days. Researchers will measure changes in inflammation, itching, and pain …

This early-stage trial tests whether adding Pedmark to standard cisplatin chemotherapy can prevent hearing loss in men with metastatic testicular cancer. About 80% of patients currently develop hearing damage from cisplatin. Pedmark works by neutralizing harmful molecules that ca…

Many blast-exposed veterans struggle to hear in noisy places even though their standard hearing tests are normal. This study tests whether a new fitting method called speech-based audiometry (SBA) makes low-gain hearing aids more effective than the usual approach. Eighty veterans…

This study tests a new way to treat chronic tinnitus by pairing gentle electrical stimulation on the back of the head with a listening exercise. One hundred adults with constant ringing in the ears will be randomly assigned to receive real or fake stimulation combined with active…

This study tests if lip reading rehabilitation improves how well people with hearing aids can recognize spoken words by watching a speaker's mouth. Eight adults with moderate to severe hearing loss will participate. The goal is to see if this therapy helps them understand speech …

This study tests whether automatic sound processing in cochlear implants helps children with hearing loss understand speech in noisy environments. Twenty children aged 6 to 16 who use cochlear implants will compare three different sound settings. The goal is to see which setting …

This trial tests whether a set of three virtual-reality games, called BEARS, can improve hearing in noisy places for children aged 8 to 16 who have two cochlear implants. The games train the brain to pick out speech from background noise, locate where sounds come from, and enjoy …

This study tests whether mild-gain hearing aids (boosting sound by about 8 decibels) can reduce the distress and loudness of tinnitus in adults with normal hearing. Fifteen participants will try both the active device and a placebo (no amplification) for three weeks each. The goa…

This study tests whether a special belt that vibrates can help people with balance disorders walk better and feel more steady. Researchers will enroll 90 adults aged 18-80 who have balance issues from conditions like inner ear problems or ataxia. Participants will use the belt an…

This study tests whether wearing Boarding Ring glasses can help people with vestibular neuritis (a sudden, severe vertigo attack) recover their balance more quickly. Researchers will measure changes in balance and eye movements over one week in 51 adult patients. The glasses are …

This study tests whether a new nasal spray system that delivers fluticasone deeper into the nose can relieve Eustachian tube dysfunction (ETD) — a condition causing ear pressure, popping, and muffled hearing. About 80 adults with chronic ETD will receive either the active spray o…

This study tests if a text-messaging system called Florence can help new hearing aid users wear their devices more often. About 70 adults getting their first NHS hearing aid will either receive standard care or also get supportive texts. The goal is to see if this simple approach…

This study tests whether virtual reality exercises can help people with balance problems caused by a weak inner ear on one side. 48 adults will be split into three groups: one doing standard balance exercises, one using VR, and one doing both. The goal is to see if VR can reduce …

This study tests whether a non-invasive brain stimulation technique called TMS can reduce the ringing or buzzing of chronic tinnitus. Fifty adults with tinnitus will receive 10 real and 10 fake (sham) treatments in random order, with a two-week break in between. An MRI scan is us…

This study tests whether etanercept, a drug that blocks inflammation, can reduce the severity of tinnitus (ringing in the ears) caused by blast or noise exposure or traumatic brain injury. About 88 adults with moderate to severe tinnitus will receive either the drug or a placebo …

This study is testing a type of talk therapy, called Brief Cognitive Behavioral Therapy for Suicide Prevention, delivered via video call. The goal is to see if it can reduce suicidal thoughts and attempts in adults with physical disabilities affecting vision, hearing, or mobility…

This study is testing a new rechargeable behind-the-ear hearing device kit from Sonova. It aims to see if the device helps adults with hearing loss in challenging listening situations and improves speech understanding in noisy environments. Twenty experienced hearing aid users wi…

This study tests a safe, low-dose electrical brain stimulation technique called tDCS to see if it can reduce the loudness and distress of tinnitus (ringing in the ears). Forty adults with tinnitus will receive multiple sessions, and researchers will measure changes in symptoms an…

This study tests a virtual reality training program (KidTrain) designed to help children aged 7-17 with bilateral cochlear implants improve their ability to locate sounds and understand speech in noisy environments. The training uses immersive VR with varying background noise and…

This study tests whether a new AI-based noise reduction feature in Phonak hearing aids helps people with hearing loss or cochlear implants hear speech more clearly in noisy settings. Researchers will measure how well 500 participants repeat words and sentences in quiet and noisy …

This study looks at whether combining a non-invasive brain stimulation technique called rTMS with hearing aids can improve cognitive function in older adults with age-related hearing loss. About 189 participants, including those with and without hearing aids, will receive two 14-…

This study compares two ways of tuning cochlear implants for people who also use a hearing aid in the other ear. The new method aims to match the implant's sound processing to the natural pitch map of the ear. Twenty adults with hearing loss will try both tuning methods to see wh…

This study compares two fitting methods for people who use a cochlear implant in one ear and a hearing aid in the other. One method synchronizes the devices, the other does not. Researchers want to see if synchronization helps with sound localization and speech understanding in n…

This study tests if a noninvasive cooling device can safely relieve tinnitus (ringing in the ears). Forty adults with chronic tinnitus will use the ReBound device for 30 minutes in one session and then at home for six months. Researchers will compare their symptoms to a control g…

This study tests whether vestibular therapy—a set of head-movement exercises done with a physical therapist—can reduce falls in people with Alzheimer's disease who also have inner-ear balance problems. About 100 participants aged 60 and older will receive either the therapy or st…

This study tests whether a 5-week audio-proprio-phonatory training program can reduce the daily-life disability caused by chronic tinnitus. 56 adults with tinnitus will either receive the training or not, and researchers will use brain wave recordings (EEG) and questionnaires to …

This pilot study tests whether a new training program called SEBAR can improve confidence and success with over-the-counter (OTC) hearing aids. Twenty-seven adults with mild-to-moderate hearing loss who have never used hearing aids will wear OTC devices for a week and answer ques…

This study tests whether adding neck therapy (cervical mobilization) to standard balance exercises can reduce dizziness and improve balance in people with Meniere's disease. 33 adults with Meniere's will be split into three groups: one getting only their usual medication, one add…

This study tests a new type of hearing aid that is built into glasses. It is for adults 18 and older who have mild to moderate hearing loss and already wear glasses. The goal is to see if the device helps people hear better in noisy places and is safe to use. About 89 people will…

This study is testing a new software algorithm called SEDA that reduces background noise for cochlear implant users. Researchers will measure how well 60 participants (ages 12 and older) understand speech in quiet and noisy settings with and without the algorithm. The goal is to …

This study tests a new noise-reduction feature for hearing aids that uses deep neural networks to help people hear speech better in noisy settings. Fifty adults with mild-to-moderate hearing loss will listen to sentences at different noise levels while using three settings: no no…

This study tests whether a personalized form of brain stimulation (TMS) can better reduce chronic tinnitus (ringing in the ears) than the standard approach. 116 adults with bothersome tinnitus for over 6 months will receive five days of stimulation, with their progress tracked fo…

This study tests an injection called KP-100LI for people with vocal fold scars that cause voice problems. About 62 adults will receive either the study drug or a placebo to see if it improves voice function over 24 weeks. The goal is to confirm the treatment is safe and effective…

This study looks at whether adding Brandt-Daroff exercises to the usual GANS maneuver can reduce dizziness and improve quality of life for people with BPPV, a common inner-ear condition that causes brief spinning spells. About 30 adults with BPPV will be split into two groups: on…

This study tests whether a gentle electrical stimulation on the ear (taVNS) can improve speech understanding in noisy environments for older adults with age-related hearing loss. 36 participants aged 55-80 will receive either active or sham stimulation. The goal is to see if this…

This study tests a 12-week program called ENACT that combines hearing exercises, memory training, and family support for people with mild cognitive impairment and hearing loss. Researchers want to see if it improves thinking, hearing, and quality of life compared to usual care. T…

This study tests whether hearing aids can improve quality of life in cancer patients who develop hearing loss from platinum-based chemotherapy. Fifty-two adults currently on such chemotherapy and with confirmed hearing loss will be randomly assigned to receive a hearing aid or st…

This study tests a new way to program cochlear implants to help children and adults with severe hearing loss hear better. Researchers will compare the new programming to standard settings and measure how well participants understand speech. The goal is to improve hearing outcomes…

This study tests a new hearing aid, Audiocap, in 100 adults with mild-to-moderate hearing loss who have never used a hearing aid before. The goal is to see if it improves hearing better than a placebo device after one month of use. Participants will undergo standard hearing tests…

This study tests whether six months of music therapy, starting right after cochlear implant surgery, can improve a person's ability to understand speech in noisy places. Thirty adults who speak German will be split into groups: some start music therapy immediately, some start lat…

This study compares using virtual reality glasses versus the standard 'show-do' technique to reduce dental anxiety in 54 children with moderate to severe hearing impairment. The children will have their pulse and anxiety scores measured during a dental cleaning. The goal is to se…

This study tests whether a personal sound amplifier, along with hearing training, can reduce troubling symptoms like agitation and distress in older adults with Alzheimer's or related dementias who also have hearing loss. Researchers will enroll 300 people aged 60-100 and their c…

This study tests whether adding Buteyko breathing exercises to a smoking hygiene program can improve Eustachian tube function and lung health in 40 teens who are regularly exposed to secondhand smoke at home. Participants will practice the breathing technique daily for 6 months. …

This study tests whether adding traditional Chinese medicine and acupuncture to standard Western treatment helps people with sudden hearing loss recover faster and feel better. Researchers will compare standard care alone versus combined treatment in 64 adults who recently lost h…

This study looks at whether stimulating deeper parts of the inner ear with a cochlear implant helps people hear music better. About 32 adults with hearing loss who already qualify for a cochlear implant will test two different stimulation depths. The goal is to see if the deeper …

This study tests a device called SWAN that guides people through head movements to reduce motion sickness and improve balance. It is for adults with inner ear disorders, motion sickness, or those recovering from vestibular schwannoma surgery. Participants use the device at home f…

This study looks at whether giving Veterans who have trouble hearing a small personal amplifier in the emergency room can help them understand their discharge instructions better and lower their chances of coming back to the ER within 3 or 30 days. About 1,050 Veterans from six V…

This study looks at whether changes in brain waves can objectively measure tinnitus improvement after using a non-invasive device. The device delivers sound through headphones and mild electrical pulses to the tongue. Twenty-four adults with chronic tinnitus will use the device d…

This study tests whether a stabilizing occlusal splint (a type of mouthguard) can reduce tinnitus (ringing in the ears) in people who also have temporomandibular joint (TMJ) disorder. Researchers will compare the real splint to a placebo splint in 63 adults over 4 months, measuri…

This study tests three hearing aid adjustments to help people with hearing loss understand speech in noisy, multi-talker settings. Researchers will compare how well 220 participants (with normal hearing or hearing loss) can pick out words and sense where sounds come from, with an…

This study tests a 6-week, internet-based mindfulness program for adults with chronic tinnitus—a condition that can cause anxiety, depression, and poor quality of life. The program includes guided meditations and cognitive exercises, with no therapist support. Researchers will co…

This study tests whether Buteyko breathing exercises can ease chronic Eustachian tube dysfunction in seniors. Forty older adults with long-term ear blockage will either receive standard care (nasal spray and medication) or standard care plus 30 minutes of Buteyko breathing twice …

This study tests a personalized sound therapy for people with chronic tinnitus (ringing in the ears lasting over 6 months). Researchers will use each participant's hearing loss and tinnitus pitch to create custom audio signals. The goal is to see if this acoustic stimulation redu…

This study looks at whether over-the-counter hearing aids can improve communication for older adults with mild cognitive impairment and mild to moderate hearing loss. Fifty participants and their communication partners will be randomly assigned to try hearing aids first or receiv…

This study looks at a type of tinnitus called somatosensory tinnitus, where ringing in the ears changes with head, neck, or jaw movements. Researchers are testing whether physical therapy, sound-based therapy, or a combination of both can help. The study involves 72 veterans with…

This study is testing whether joining a choir for 12 weeks can help older adults (60+) with mild-to-moderate untreated hearing loss understand speech better and improve their mood and social connections. 210 participants will be randomly assigned to either a weekly group singing …

This study tests whether a mild cooling device worn on the head for 30 minutes can reduce the severity of chronic tinnitus (ringing in the ears). Eighty adults with constant tinnitus will either receive the cooling therapy or a sham device. Researchers will measure changes in tin…

This study tests whether community healthcare workers can effectively fit hearing aids using a smartphone app in low- and middle-income communities. 90 adults with mild to severe hearing loss will be randomly assigned to receive either a smartphone-based fitting, a pre-set fittin…

This study investigates whether brain imaging can predict how well children with cochlear implants will develop language skills. Researchers are building models to forecast long-term language outcomes in English- and Spanish-speaking children. They are also testing a parent-led c…

This study follows adults who have recently received a cochlear implant to track how their ability to distinguish sounds and understand speech changes over time. Participants complete at-home sound tests frequently during the first three months, then return for lab tests up to on…

This study investigates whether older adults with age-related hearing loss (presbycusis) can still hear and enjoy the sound of a crunchy biscuit while eating. Researchers will compare a crunchy biscuit with a soft one in 100 seniors aged 65 and older, asking them if they hear the…

This study aims to better understand disorders that cause hearing to fluctuate, such as Meniere's disease. Researchers will use advanced MRI scans and blood tests to look for biomarkers linked to hearing changes. The goal is to identify different types of these disorders and pave…

This study is looking at whether people with a common inner-ear condition called benign paroxysmal positional vertigo (BPPV) have lower vitamin D levels than those without it. Researchers will compare vitamin D in 160 adults — half with BPPV and half without. The goal is to see i…

This study is testing a new tool called HPARSS that helps doctors identify childhood cancer survivors at risk for hearing or vision problems. The tool uses a patient's past cancer treatments to flag who needs screening. Researchers will see if this approach leads to more kids get…

This study looks at whether listening to music with a steady beat can improve how older adults with age-related hearing loss process sentences. Researchers will have 55 participants aged 70 or older listen to regular or irregular rhythm music, then judge if sentences are grammati…

This study aims to create a large collection of tissue samples from people with head and neck disorders, such as hearing loss, mouth diseases, and throat cancers. Researchers will use leftover surgical tissue and additional samples like blood, saliva, and cheek swabs to study the…

This study looks at why some people aged 60 and older have trouble understanding speech in noisy settings, even though their standard hearing tests are normal. Researchers will use hearing tests and brain scans to see if the problem is related to how the brain processes sound tim…

This study analyzes dried blood spots from 630 newborns to find protein and RNA markers that could predict which babies with congenital CMV will develop hearing loss or other problems. Researchers will compare samples from infected babies who had complications, those who did not,…

This study will follow 5,000 children and teens with hearing loss and normal hearing over time. Researchers will measure changes in hearing, speech, language, and brain scans to see how different treatments—like hearing aids, cochlear implants, or gene therapy—affect development.…

This study looks at whether a vestibular implant (a device that helps with balance) can improve how people with severe inner ear damage perform tasks like staying upright, navigating, and thinking. About 20 people who already have the implant will be tested with it on and off, an…

This study follows 180 children up to age 16 who have hearing loss caused by mutations in the GJB2 or OTOF genes. Researchers will regularly measure their hearing using standard tests and questionnaires to see how it changes over time. The goal is to better understand the natural…

This study looks at how people with normal hearing, hearing loss, or cochlear implants use nearby sounds to recognize speech. Researchers will test participants' ability to identify words and sentences in quiet and noisy settings. The goal is to better understand how hearing aids…

This study observes 60 children with severe hearing loss who received cochlear implants before age 2. Researchers will track their speech therapy sessions and language skills over time to see which therapy approaches and how much therapy lead to better language development. The g…

This study looks at whether programming a cochlear implant from home works as well as doing it in the clinic. About 51 adults with hearing loss will have their device adjusted both remotely and in-office to compare hearing test results. The goal is to see if remote programming is…

This study looks at whether people with new cochlear implants can have fewer follow-up appointments and still get good results. Researchers will test a new programming method that may make each visit shorter. About 48 adults who are getting a Cochlear Americas implant will take p…

This study uses PET scans to watch brain activity while people with cochlear implants try to understand speech in background noise. Researchers want to pinpoint which brain regions help make sense of sound in challenging listening situations. The study includes 120 cochlear impla…

This study aims to objectively measure how social older adults with hearing loss are, and whether hearing aids improve social engagement and thinking skills. Researchers will use a wearable audio sensor to track conversation patterns and optional EEG to measure brain responses to…

This study looks at how multiple sclerosis (MS) affects hearing. Researchers will test hearing and analyze spinal fluid from 30 adults with MS to see if hearing problems are linked to inflammation in the body. The goal is to better understand MS, not to test a new treatment.

This study looks at adults aged 30 to 55 who have hearing loss that started after age 16 and carry a mutation in the GJB2 gene. Researchers will track how their hearing changes over time using hearing tests and genetic analysis. The goal is to better understand this form of heari…

This study looks at people with a type of inherited hearing loss (called DFNA) and their family members to learn which genes cause it. Researchers will collect hearing tests, balance tests, blood samples, and skin biopsies over up to 20 years. The goal is to gather information th…

This study tests a patient navigation program to help rural adults in Kentucky get hearing tests. 500 participants from primary care clinics will receive guidance every two weeks to overcome barriers like travel and cost. The goal is to see if more people complete diagnostic hear…

This study tests a telemedicine program called STAR that brings hearing specialists into schools via smartphone or tablet. It aims to reduce the number of children who get lost to follow-up after a school hearing screening. Over 8,000 students in rural Alaska will take part, with…

This study looks at whether simpler hearing aid settings work better for older adults with Alzheimer's dementia or mild memory problems. Researchers will test two different hearing aid programs in 20 participants to see which one helps them understand speech in noisy settings and…

This study tests whether hearing aids with built-in sensors and artificial intelligence can assess a person's risk of falling and help them hear better in noisy environments. Researchers at Stanford University will enroll 350 adults aged 55 and older who already wear hearing aids…

This study collects medical information and samples from people with hearing, balance, taste, smell, voice, speech, or language disorders. Researchers aim to use this data for future studies and to find candidates for other research. Participants receive standard care, and no exp…

This study tests whether cinematic virtual reality (VR) is more effective than traditional lectures for teaching medical students about geriatric care. One hundred students at Ohio University will be randomly assigned to either VR training or a lecture. The VR group will experien…

This study is testing whether auditory training can help people, especially older adults, understand speech in noisy environments. Researchers will compare different training methods in 1,260 participants aged 18-30 and 60-85. The goal is to find out which approaches work best an…

This study looks at whether a balance exercise called IVA is safe and helpful for adults who have vision problems, with or without inner-ear balance issues. Researchers will compare two groups: people with vision problems only and those with both vision and inner-ear problems. Pa…

This observational study looks at how much mental energy children aged 6-18 with cochlear implants use when listening, and whether that extra effort slows their brain development over three years. Researchers will compare 240 children with cochlear implants to 120 children with n…

This study looks at how common hyperacusis (sensitivity to everyday sounds) and misophonia (strong negative reactions to specific sounds) are among teachers, and whether these conditions add to their work stress. Researchers will survey 500 teachers in Turkey to measure these sen…

This study is looking at whether people with benign paroxysmal positional vertigo (BPPV) have differences in their autonomic nervous system compared to healthy people. Researchers will measure heart rate variability (HRV) in 104 participants (52 with BPPV and 52 matched controls)…

This study surveys 500 adults with chronic tinnitus to understand their preferences about a future brain implant that could ease their symptoms. Participants answer questions about their willingness to undergo surgery, accept risks, and pay for such a device. The results will hel…

This study aims to uncover genetic and biological differences between people with Menière's disease, those with vestibular migraine, and healthy individuals. Researchers will analyze blood samples from 250 participants to look for specific gene variations and biohumoral factors. …

This study tests a virtual reality (VR) game to measure hand-eye coordination in children aged 7 to 17 with and without chronic balance (vestibular) disorders. Researchers want to see if the VR tasks are reliable and fun for kids, and how balance problems affect coordination. The…

This large observational registry aims to collect data from over 13,000 adults across Europe with rare head and neck cancers, including cancers of the nasopharynx, nasal cavity, salivary glands, and middle ear. Researchers will track patient outcomes like survival, treatment resp…

This study looks at whether adjusting the difficulty of online listening exercises can help adults with hearing problems learn better. Researchers will have 120 participants do 30 minutes of training per day for two weeks. The goal is to understand how task difficulty affects lis…

This study looks at how people with hearing aids perceive the timbre (quality) of sounds and understand complex sound scenes, like music or crowded rooms. Researchers will compare 75 adults aged 60-75 with and without hearing loss. Participants will listen to sounds and rate how …

This study looks at whether a noninvasive device that stimulates the vagus nerve can improve the ability to understand speech in noisy environments for people who have had a traumatic brain injury. Researchers will compare brain responses and speech test scores with and without t…

This study looks at how often young children get ear infections from RSV, a common virus. Researchers will track 1900 children under 2 years old to see how many have RSV-related ear infections, with or without bronchiolitis. The goal is to better understand the burden of RSV in t…

This study collects a small sample of fluid from the ears of children aged 3 months to 15 years who have a draining ear infection (otorrhea). The goal is to identify which bacteria are present using standard lab tests and newer molecular methods. By understanding the bacterial ca…

This study explores whether very small, barely noticeable movements can help retrain the brain's balance system in people with inner ear problems. Researchers will test balance and motion sensitivity in 48 adults with certain balance disorders and healthy volunteers. The goal is …

This large observational study is checking how pneumococcal vaccines have changed the types of bacteria living in children's noses. Researchers will compare healthy children and those with ear infections to see which bacterial strains are present and whether they resist antibioti…

This study aims to translate and test the Situational Vertigo Questionnaire (SVQ) in Turkish. The SVQ measures dizziness triggered by visual environments like supermarkets or driving. Researchers will check if the Turkish version is valid and reliable by comparing it with other d…

This study follows up to 150 people with hearing loss caused by changes in the otoferlin gene. Researchers will measure hearing function using tests like auditory brainstem response (ABR) and otoacoustic emissions (OAE). The goal is to learn how this type of hearing loss changes …

This study aims to improve how children with cochlear implants perceive sound by testing new sound coding strategies. Researchers will compare hearing performance between children and adults, and between those with implants and those with normal hearing. The goal is to understand…

This study looks at 20 adults with hearing loss in one ear but a normal-looking eardrum. Doctors want to see how often their best guess about the cause matches what they find during a small ear surgery. The goal is to improve diagnosis and treatment for this tricky condition.

This study aims to find out why hearing aids work well in quiet labs but not in noisy real-world settings. About 45 adults with hearing loss who already use hearing aids will listen to different sound scenarios and rate their experience. The goal is to improve hearing aid perform…

This nationwide study aims to understand how hearing loss affects thinking, language, reading, and emotional wellbeing in 256 deaf or hard-of-hearing adolescents. Researchers will use tests and questionnaires to measure speech perception, cognitive skills, and school burnout. No …

This study is gathering information from 100 children and adults who use MED-EL hearing devices, including implants and non-implantable devices. Researchers will collect data on hearing ability, speech understanding, and quality of life through tests and questionnaires. The goal …

This study tests if adults having awake ear surgery can hear short electrical pulses applied to a part of the inner ear. Researchers want to see if people can tell different frequencies apart. The results could help design better hearing implants. About 18 participants will be in…

This study aims to understand why people with Turner syndrome often lose their hearing. Researchers will look at genetic and epigenetic markers in 150 adults aged 18-60. Participants will have hearing, balance, blood, and imaging tests. The goal is to find new ways to treat or de…

This study is building a registry of 100 people with hearing loss caused by changes in the CABP2 gene. Researchers will collect hearing test results and genetic information to learn how the condition progresses over time. The goal is to better understand the disease, not to test …

This study observes how children and adults with hearing loss who use cochlear implants and preserve some natural hearing process sound, especially in noisy settings. Researchers will measure hearing abilities over time in 200 participants, including those with normal hearing for…

This study tests whether a two-part approach—improving communication about viral infections and having pharmacists double-check prescription lengths—can reduce how many days antibiotics are prescribed for respiratory infections like bronchitis, sinusitis, and sore throat. About 4…

This study measures how well people with and without vestibular (balance) disease can sense motion through vision and balance. Researchers hope to learn how aging and disease change motion perception. About 300 healthy adults and patients with balance disorders will participate i…

This study collects information from 450 newborns who fail their initial hearing screening. Doctors will test them for congenital CMV, a common infection that can cause hearing loss and other problems. The goal is to see how often CMV is found and to improve follow-up care for af…

This study is a registry that will follow 300 children under 18 who receive a balloon dilation treatment for Eustachian tube dysfunction. Researchers will track how often the procedure fails and needs repeat surgery. The goal is to confirm the device's real-world performance in k…

This research study looks at how children and adults who use cochlear implants or auditory brainstem implants hear and understand sounds. Participants will listen to words, sentences, and tones to see how well they identify speech and tell differences in loudness or pitch. The go…

This study explores whether a brain-scanning technique called fNIRS can measure how well hearing aids help young children with hearing loss. Researchers will compare brain activity in 40 infants (3-18 months old) with normal hearing and those using hearing aids. If fNIRS proves r…

This study looks at whether inner-ear balance (vestibular) problems make reading harder for children with hearing loss. Researchers will test 90 children, some with normal hearing and some with severe hearing loss, measuring their ability to see clearly during head movements and …

This study looks at whether sleep disorders make vertigo worse for people with Ménière's disease, a condition that causes hearing loss, ringing in the ears, and dizziness. Researchers will track 100 adults to see if those with more severe vertigo also have more sleep problems. Th…

This study is building a worldwide registry for people with Wolfram syndrome, a rare genetic disorder causing diabetes, vision loss, and hearing problems. Researchers will track how the disease progresses over time and analyze participants' genetic information. The goal is to bet…

This study looks at how older adults with hearing loss understand speech in noisy settings, and how hearing aids can help. Researchers will test 121 people, including young and older adults with normal hearing and older adults with hearing loss. They will measure both behavior (l…

This study will test how much sound amplification three different bone-anchored hearing devices can provide. Twenty adults with mixed hearing loss who already use such a device will have their current device swapped and measured. The goal is to see if one device offers more usabl…

This study follows 19 adults with hearing loss who already received a cochlear implant that releases a steroid to reduce inflammation. Researchers will check how well the implant works over 5 years by measuring electrical signals and tracking any side effects. The goal is to see …

This study looks at how people with cochlear implants understand speech in everyday situations, like conversations with background noise. Researchers will test 460 adults (both with and without hearing loss) using listening tasks that measure effort and comprehension. The goal is…

This early-phase study will give IV lidocaine to 40 adults with or without tinnitus and hearing loss, then use fMRI to see how the drug changes brain activity. Participants act as their own control, comparing scans before and after the infusion. The goal is to identify neural net…

This study aims to see if a one-time health assessment and advice session can improve the overall vascular health of 1,000 adults living in Innsbruck, Austria. Participants will have their heart and blood vessel health measured using a standard score called Life's Essential 8, wh…

This study collects leftover tissue samples and additional blood, saliva, and cheek swabs from up to 1,000 people with hearing, balance, smell, taste, voice, or speech disorders. The samples are stored in a biobank for researchers to study the biology of these conditions. No new …

This study follows 50 adults aged 18–85 with certain types of hearing loss who either use or could use an FDA-approved bone-anchored hearing device. Over 3 years, researchers will measure changes in memory, attention, and other thinking skills. The goal is to see if treating hear…

This study explores whether a test that measures brain waves in response to visual images can be used in a new way for people with hearing loss. Researchers will compare these brain responses to standard hearing tests and thinking skills tests. The goal is to see if this test can…

This study tests a teaching method called 'shape coding' to help deaf and hard of hearing middle schoolers improve their written English. Researchers will work with 30 students in grades 5-8 who use both spoken English and American Sign Language. The goal is to see if using visua…

This study looks at how children and adults with cochlear implants and some natural hearing understand speech in noisy environments and locate where sounds come from. Researchers will test 160 participants, including those with normal hearing and those with cochlear implants. The…

This study looks at how families feel about antibiotic use and whether a Garmin smartwatch can track symptoms in children aged 4-17 with common infections like UTIs, tonsillitis, or skin infections. About 300 children from the Royal Children's Hospital Emergency Department will w…

This study looks at how children and adults with cochlear implants understand and express emotions through speech. Researchers will measure how well participants recognize emotions in voices and how they produce emotional sounds. The goal is to find out why some implant users str…

This study compares cognitive function in 180 adults aged 45-64 with severe hearing loss to those with normal hearing. Participants take memory, attention, and thinking tests. The goal is to see if hearing loss is linked to mild cognitive impairment earlier in life.

This study tests whether a small recording device called LENA can help speech therapists guide parents to improve their child's language environment. Thirty children with profound congenital deafness who received a cochlear implant before 18 months old will wear the recorder at h…

This study tests whether a special monitoring tool called electrocochleography can help surgeons preserve a patient's remaining natural hearing while placing a cochlear implant. About 40 adults with severe hearing loss in both ears will be randomly assigned to receive the monitor…

This study tests whether measuring a tiny ear muscle reflex (the stapedial reflex) can help doctors set the right volume levels on cochlear implants for children. Currently, kids must describe how loud sounds feel, which can be tricky. The researchers will compare reflex measurem…

This study compares how well people with a genetic form of deafness (DFNB9) can hear and understand speech after receiving gene therapy versus a cochlear implant. Researchers will also include healthy participants for comparison. The goal is to see if gene therapy can match or ou…