Lidocaine injection reveals tinnitus brain networks in tiny pilot
NCT ID NCT04192773
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase study will give IV lidocaine to 40 adults with or without tinnitus and hearing loss, then use fMRI to see how the drug changes brain activity. Participants act as their own control, comparing scans before and after the infusion. The goal is to identify neural networks linked to chronic tinnitus, not to test a treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- IV lidocaine
- What this could lead to
- If successful, this could help identify brain networks involved in tinnitus, pointing toward future targeted treatments.
- What could go wrong
- This is a very early, small pilot study (40 people) with no control group. It is designed to explore brain changes, not to test a treatment, so results may not lead to any therapy.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Massachusetts Eye and Ear Infirmary
RECRUITINGBoston, Massachusetts, 02114, United States
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