Can a pill save your hearing after a cochlear implant?

NCT ID NCT06340633

Recruiting now Disease control Sponsor: Sound Pharmaceuticals, Incorporated Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This phase 2 trial tests whether the drug SPI-1005 can prevent hearing loss and reduce side effects like tinnitus and vertigo in adults receiving a cochlear implant. Forty participants will take either the drug or a placebo for 6 months, starting 2 days before surgery. The study will compare safety and hearing outcomes between the two groups.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ebselen (SPI-1005)
What this could lead to: If it works, this could point toward a treatment to protect hearing and reduce side effects like tinnitus and vertigo after cochlear implant surgery.
What could go wrong: This is a small, early-phase trial with only 40 participants. The drug may not show benefit over placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hearing loss disorder sensorineural hearing loss disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COCHLEAR TRAUMA HEARING LOSS

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Medical College of Wisconsin
NOT_YET_RECRUITING

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Ohio State University
RECRUITING

Columbus, Ohio, 43212, United States
Thomas Jefferson University
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
University of Iowa
RECRUITING

Iowa City, Iowa, 52242, United States
University of Texas Southwestern
RECRUITING

Dallas, Texas, 75390, United States

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