New hope for hard-to-treat lung cancer: experimental drug targets MET gene

NCT ID NCT04077099

Recruiting now Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an experimental drug called REGN5093 in people with advanced non-small cell lung cancer that has a specific change in the MET gene. The first part finds a safe dose, and the second part checks if the drug can shrink tumors. About 231 participants will take part.

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Conditions

The condition(s) this trial relates to.

autosomal recessive nonsyndromic hearing loss 39 Neoplasm Metastasis non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NSCLC

Contacts and locations

Locations

Ajou University Hospital
RECRUITING

Suwon, Gyeonggi-do, 16499, South Korea
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Boramae Medical Center
RECRUITING

Seoul, 07061, South Korea
Centre Francois Baclesse (CFB)
COMPLETED

Caen, Normandy, 14076, France
Centre Georges Francois Leclerc
WITHDRAWN

Dijon, Bourgogne-Franche-Comté, 21034, France
Centre Hospitalier Regional Universitaire (CHRU) Montpellier Arnaud de Villeneuve
COMPLETED

Montpellier, 34295, France
Centre Hospitalier Universitaire de Grenoble
COMPLETED

Grenoble, 38043, France
Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou
COMPLETED

Rennes, Bretange, 35033, France
Chonnam National University Hwasun Hospital
RECRUITING

Hwasun, Jeollanam-do, 58128, South Korea
Chungbuk National University Hospital
RECRUITING

Cheongju-si, North Chungcheong, 28644, South Korea
DNU_Massachusetts General Hospital_DNU
WITHDRAWN

Boston, Massachusetts, 02114, United States
Dana Farber Harvard Cancer Center Consortium
COMPLETED

Boston, Massachusetts, 02215, United States
Duke Cancer Center
WITHDRAWN

Durham, North Carolina, 27710, United States
Fox Chase Cancer Center
WITHDRAWN

Philadelphia, Pennsylvania, 19111, United States
Gachon University Gil Medical Center
RECRUITING

Incheon, Namdong-gu, 21565, South Korea
Georgetown University Medical Center
COMPLETED

Washington D.C., District of Columbia, 20007, United States
Haeundae Paik Hospital
RECRUITING

Pusan, Gyeongsangnam-do, 48108, South Korea
Harold C. Simmons Comprehensive Cancer Center
WITHDRAWN

Dallas, Texas, 75235, United States
Henry Ford Health System
WITHDRAWN

Detroit, Michigan, 48202, United States
Icahn School of Medicine at Mount Sinai
COMPLETED

New York, New York, 10029, United States
Institut Bergonie
COMPLETED

Bordeaux, New Aquitaine, 33076, France
Korea University Guro Hospital
RECRUITING

Seoul, 08308, South Korea
Memorial Sloan Kettering Cancer Center
COMPLETED

New York, New York, 10065, United States
Moffitt Cancer Center - McKinley Drive
RECRUITING

Tampa, Florida, 33612, United States
NYU Cancer Institute
WITHDRAWN

New York, New York, 10016, United States
National Cancer Center
RECRUITING

Gyeonggi-do, Gyeonggi-do, 10408, South Korea
Pusan National University Hospital
RECRUITING

Busan, 49241, South Korea
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Seol St. Mary's Hospital
COMPLETED

Seoul, 06591, South Korea
Seoul National University Bundang Hospital
RECRUITING

Seongnam-si, Gyeonggi-do, 13620, South Korea
Seoul National University Hospital
RECRUITING

Seoul, 3080, South Korea
Severance Hospital Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
Stephenson Cancer Center
WITHDRAWN

Oklahoma City, Oklahoma, 73104, United States
The Catholic University Of Korea St. Vincent's Hospital
RECRUITING

Suwon, Gyeonggi-do, 16247, South Korea
The University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
University of Alabama at Birmingham
WITHDRAWN

Birmingham, Alabama, 35294, United States
University of California Irvine Medical Center - Bldg 56, RT81, Rm 241
COMPLETED

Orange, California, 92868, United States
University of Kentucky, Markey Cancer Center Clinical Research Organization
WITHDRAWN

Lexington, Kentucky, 40536, United States
University of Pittsburgh UPMC - Clinical Research Services
COMPLETED

Pittsburgh, Pennsylvania, 15232, United States
Washington University School of Medicine
WITHDRAWN

St Louis, Missouri, 63110, United States

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