Auditory system disorder

This study tested whether miconazole oil can cure fungal ear infections (otomycosis). 112 adults with ear fungus received either the active oil or a placebo for 14 days. Neither patients nor doctors knew who got the real treatment. After two weeks, doctors checked if the infectio…

This study tested a new vaccine called V114 in over 7,000 healthy infants to see if it could prevent ear infections caused by certain pneumococcal bacteria. The vaccine was given alongside routine childhood shots. Researchers tracked how many babies got vaccine-type ear infection…

This early-stage trial tested whether a new whole-cell pneumonia vaccine is safe for people. Thirty healthy adults received either the vaccine or a placebo and were monitored for 30 days. The main goal was to check for side effects like pain, fever, or headache. This study does n…

This study tested an experimental drug called SPI-1005 (ebselen) in 254 adults with Meniere's disease, a condition causing hearing loss, ringing in the ears, and dizziness. Participants received either the drug or a placebo for a set period, followed by an open-label phase where …

This study tests whether SPI-1005, a drug containing ebselen, can prevent hearing loss in people with cystic fibrosis who are receiving IV tobramycin for a lung infection. About 40 participants will receive either a placebo or one of three doses of SPI-1005 for 21 days. Researche…

This study tested whether using a patient's own platelet-rich plasma (PRP) during eardrum repair surgery improves healing. 48 adults with chronic ear infections and eardrum holes were split into two groups: one got PRP-soaked sponges placed in the ear during surgery, the other go…

This study tested a new cochlear implant (CI632) in 10 adults who have some low-frequency hearing but poor high-frequency hearing. The goal was to see if the implant improves speech understanding and overall hearing. Participants received the implant and were followed to measure …

This early-phase trial tested a special insulin gel applied directly to the ear drum after surgery to repair a long-standing hole. Fifty adults with dry ear drum perforations received either the insulin gel or a plain foam control. The insulin group showed significantly better he…

This study tested whether telehealth can replace in-person clinic visits for older adults who already use hearing aids. 339 participants were randomly assigned to receive hearing care either through telehealth or traditional clinic visits. The goal was to see if telehealth could …

This study tested two types of cochlear implants in 37 adults with severe-to-profound hearing loss who had never used an auditory implant before. The goal was to see how safe the implants are and how well they help people understand speech in quiet and noisy settings. Participant…

This study tested whether dornase alfa (Pulmozyme) ear drops can unclog tympanostomy tubes in children better than standard ofloxacin drops. 41 children aged 1 to 18 with clogged tubes received either treatment for 7 days. The main goal was to see if the tube was open at day 14.

This study compared two ways of preparing a tissue graft (temporalis fascia) for repairing holes in the eardrum caused by chronic ear infections. 92 adults aged 18–60 received either a wet or dry graft during tympanoplasty surgery. Researchers checked hearing improvement and graf…

This study looked at whether a cochlear implant is a good value for people who are deaf in one ear or have severe hearing loss in one ear. Participants first tried other hearing devices, and if those didn't work, they were randomly assigned to get a cochlear implant right away or…

This study compared two ear drop treatments for otomycosis, a fungal infection of the outer ear that causes itching, discharge, and blockage. Sixty patients were randomly assigned to receive either clotrimazole or 2% salicylic acid drops three times daily for two weeks. The main …

This study looked at 9 children under 5 who received the BONEBRIDGE BCI 602 hearing implant. The main goal was to check if the implant is safe within the first year after surgery. Researchers also measured how much the implant improved hearing and quality of life. The implant is …

This study tested two types of cochlear implants in 30 adults with severe-to-profound hearing loss who had never used an implant before. The goal was to see if the devices are safe and help people understand speech better in quiet and noisy settings. Participants received the imp…

This study tested whether a traditional Chinese herbal pill called Liuwei Dihuang Pill can improve hearing in older adults with age-related hearing loss. 120 people aged 65-75 took either the pill or a placebo for 48 weeks. Researchers measured changes in speech recognition to se…

This study tested two common treatments for fungal ear infections: boric acid and povidone iodine. Sixty patients were treated with one of the two solutions applied directly to the ear canal. The goal was to see which one clears the infection better and reduces symptoms like pain…

This pilot study from France tested two ways to treat otosclerosis, a condition that causes hearing loss. Thirty people first used a hearing aid for at least two months, then had surgery to fix the middle ear bone. Researchers measured quality of life after each treatment to see …

This study tested a smartphone app called HearCare MED-EL that lets people with cochlear implants adjust their audio processor and check for device problems remotely. 120 adults who already had a MED-EL implant for at least 3 months took part. The goal was to see if the app works…

This study tested a new type of cochlear implant that is completely hidden under the skin, with no external parts. Thirty adults with severe hearing loss received the implant to see if it improved their ability to understand speech. Participants took word and sentence tests, hear…

This trial tested a robotic system (ROSA) to assist with cochlear implant surgery, which restores hearing in people with profound hearing loss. The robot aims to make the surgery safer and less invasive by improving precision. Nine adults eligible for cochlear implants took part,…

This study tested a special hearing device called an auditory brainstem implant in 10 children aged 2 to 5 who are profoundly deaf due to missing or damaged inner ear parts. Unlike a cochlear implant, this device is placed directly on the brainstem during surgery. The main goal w…

This study compares two surgical techniques for repairing large eardrum holes caused by chronic ear infections. The interlay method places the graft between eardrum layers, while the underlay method places it beneath. Researchers measured hearing improvement in 60 adults to see w…

This study tested the safety of taking rimegepant every day to prevent episodic migraines. 441 adults with a history of migraines took a daily 75mg tablet for up to 52 weeks. Researchers tracked side effects and lab changes to see if long-term daily use is safe and tolerable.

This study tested a wearable device that tracks eye movements during dizzy spells to help doctors tell apart three common inner-ear conditions: Ménière's disease, vestibular migraine, and BPPV. Four adults wore the device for 30 days to capture data. The goal was to develop a com…

This study tested a new MRI technique to detect endolymphatic hydrops (fluid buildup) in the inner ear of people with Meniere's disease. The new method uses a special 3D FLAIR sequence without contrast dye, compared to the standard method that requires an injection. The goal was …

This study tested whether using specialized eye-movement tests (HINTS and v-HIT) in the emergency room can help doctors correctly diagnose the cause of sudden vertigo. Researchers tracked 90 adults with acute vertigo to see if these tests reduced misdiagnosis and sped up treatmen…

This study looked for a measurable brain signal (biomarker) that could objectively diagnose chronic tinnitus. Researchers used EEG to record brain activity in 560 adults—some with constant tinnitus and some without. The goal is to replace trial-and-error diagnosis with a personal…

This study tested a new device called CochSyn that measures brain waves to detect hearing damage. Researchers compared results from 65 adults with and without hearing difficulties. The goal was to see if the device can accurately identify different types of hearing loss and be ea…

This study tested a low-cost, smartphone-connected device that checks middle ear health. Researchers compared it to standard equipment in 30 adults and children. The goal is to make ear screening affordable and easy for rural communities, reducing preventable hearing loss.

This study tested a new Swiss German speech test for children aged 4 to 6 with normal hearing. The goal was to find typical scores for how well kids hear single and double-syllable words, both in quiet and with background noise. The results will help doctors better assess hearing…

This study tested whether a special eye-tracking device (video-oculography) helps emergency room doctors more accurately diagnose the cause of vertigo or dizziness. About 130 adults with dizziness were randomly assigned to get either the eye-tracking test plus standard care, or s…

This study compared Apple AirPods Pro 2 to standard hearing aids in 21 adults with mild to moderate hearing loss. Researchers checked if the AirPods could accurately test hearing and provide sound amplification similar to a traditional hearing aid. The goal was to see if a common…

This pilot study tested whether a smartphone app can accurately measure gaze stability and the vestibulo-ocular reflex (VOR) in adults with and without balance disorders. 35 participants performed standard balance tests using both a smartphone app and a commercial computer system…

This study tested a new method called CORGEE that uses brain wave recordings (EEG) to measure how well children with hearing loss understand speech. Unlike standard hearing tests that require kids to respond verbally, this approach is objective and does not need active participat…

This study tests whether the drug SENS-401 can prevent hearing loss caused by cisplatin, a common chemotherapy. Adults with cancer who are scheduled to receive cisplatin take SENS-401 before, during, and after treatment. Hearing is measured with a standard test to see if the drug…

This study tested whether an oral drug called SPI-1005 could prevent temporary hearing changes caused by listening to loud music through headphones. 83 healthy adults took either the drug or a placebo for 4 days. The drug works by helping the body get rid of harmful chemicals pro…

This study tests an experimental drug called SPI-1005 (ebselen) in adults with Meniere's disease, a condition that causes vertigo, tinnitus, and hearing loss. The trial compares three doses of SPI-1005 against a placebo to see if it safely reduces these symptoms. Researchers will…

This study investigates whether a beetroot powder jelly candy can help competitive swimmers swim faster and feel less tired. Beetroot is rich in nitrate, which the body converts to nitric oxide, a compound that may improve blood flow and muscle efficiency. The trial involves 21 s…

This completed study tested custom in-the-ear hearing aids in 24 adults with mild-to-moderately severe sensorineural hearing loss. Participants were experienced hearing aid users who tried the study device and compared it to their own hearing aids. The goal was to measure speech …

This completed study tested a sound-based therapy for tinnitus (ringing in the ears) in 108 Veterans. Participants used hearing aids that played either notched noise (sound with the tinnitus frequency removed) or broadband white noise. The goal was to see if notched noise could r…

This study tested a balloon catheter to open blocked Eustachian tubes in 31 adults. The device is inserted into the tube and inflated to widen it. Researchers measured changes in ear symptoms over 14 months to see if the procedure provides lasting relief.

This study tested a daily, non-invasive brain stimulation technique (tRNS) in 30 adults with chronic tinnitus (ringing in the ears lasting over 6 months). The goal was to see if it could reduce the perceived loudness and annoyance of tinnitus. Participants received stimulation to…

This study tested two new features in the MED-EL SONNET 3 audio processor for cochlear implant users: the Focused Beamformer, which improves directional hearing, and the AI Mode Medium, which uses adaptive intelligence to optimize sound processing. Forty experienced cochlear impl…

This completed trial tested a personalized sound therapy for adults with chronic tinnitus, a condition where people hear ringing or buzzing without an external source. 25 participants received either music embedded with tones matched to their tinnitus frequency or low-frequency s…

This study tested whether changing how fast pressure increases during hyperbaric oxygen therapy (HBOT) can lower the chance of ear pain and injury. Over 1,500 people receiving HBOT were randomly assigned to one of two compression schedules. The goal was to see if a non-linear (sl…

This study tested three non-drug treatments—cognitive behavioral therapy, a breathing exercise, and psychoeducation—to see which best reduces the distress caused by tinnitus (ringing in the ears). Seventy adults with tinnitus were randomly assigned to one of the three approaches.…

This study tested whether laser acupuncture, a painless procedure using low-level laser light on specific points, can improve middle ear function in children aged 2-10 with otitis media with effusion (fluid behind the eardrum). Thirty-two children received either real or sham las…

This completed trial tested whether combining online acceptance and commitment therapy (ACT) with customized sound therapy helps people with tinnitus and insomnia. 164 adults were split into two groups: one received both therapies, the other only sound therapy. The goal was to se…

This study looked at two different speech therapies for children aged 6-8 who have cochlear implants. Twelve children received either perceptual training or phonetic placement therapy for 12 hours over 8 weeks. The goal was to see which therapy better improves speech clarity and …

This study tested a smartphone app that plays music with a special low-frequency beat (theta auditory beat stimulation) to see if it can reduce the stress and annoyance of tinnitus. 54 adults with chronic tinnitus used the app for 24 minutes a day for 4 weeks. The app's effect wa…

This study tested three different balance exercise programs in 45 adults with dizziness from a chronic inner ear condition. One group did standard head and eye exercises, another watched 2D moving patterns, and a third used 3D virtual reality. All groups practiced for 6 weeks, an…

This study tested whether a home-based balance therapy program is practical for children aged 4-17 with inner-ear problems that cause dizziness and balance issues. Twenty-one children did balance exercises at home for 8 weeks, with weekly check-ins from a physical therapist. The …

This study tested whether playing WiiFit games is more effective than standard balance exercises for people with dizziness and balance problems caused by inner ear issues. 42 adults aged 18-65 took part in a 4-week program. The goal was to see if the fun, interactive nature of Wi…

This study tested a special earmuff device that swaps sound from your left ear to your right ear and vice versa, called auditory mirror therapy. Researchers wanted to see if this sound-flipping trick could reduce the distress, loudness, and annoyance of chronic tinnitus. 56 adult…

This study tested two types of eye exercises—gaze stabilization and optokinetic training—in 32 adults aged 35-55 with chronic dizziness from inner ear problems. The goal was to see which better improves dizziness, balance, and confidence in daily activities. Results help guide th…

This study tested whether eye and neck exercises can reduce dizziness and uncontrolled eye movements in young adults with benign paroxysmal positional vertigo (BPPV). Fifty-six participants did either eye exercises alone or combined eye and neck exercises for six weeks. The goal …

This study tested whether a device called AirOFit PRO, which guides children through blowing exercises, can help clear fluid behind the eardrum. Fifty-one children with otitis media with effusion (OME) used the device three times daily. The goal was to see if the exercises improv…

This study tested a device called Soricle that combines mild nerve stimulation with sound to help people with tinnitus, a condition where you hear ringing or noise in your ears. 36 adults with subjective tinnitus used the device daily for 8 weeks. The goal was to see if it reduce…

This study tested a hearing aid feature called AutoFocus360, which automatically points microphones toward whoever is speaking. Thirty adults with mild to moderate hearing loss listened to audio clips and compared AutoFocus360 to standard settings. The goal was to see if it made …

This study tested a device that sends sound from the non-hearing ear to a cochlear implant in the other ear. 16 older adults with one cochlear implant used the device to see if it improved their speech understanding in noisy settings. The goal was to also see if it improved quali…

This study tested whether two combinations of migraine medications can reduce the impact of moderate-to-severe tinnitus. 78 adults were randomly assigned to receive either nortriptyline plus topiramate, verapamil plus paroxetine, or a placebo. The main goal was to see if these dr…

This completed clinical trial tested whether a dietary supplement called Tisina complex could improve cognitive health in people with mild cognitive impairment and tinnitus. About 84 adults aged 30 to 75 took either the supplement or a placebo for 90 days. Researchers measured ch…

This study tested whether speech-language teletherapy can improve language outcomes in deaf or hard-of-hearing children aged 0-27 months. Researchers enrolled 210 children, some publicly insured and some privately insured, and gave some access to an 18-month teletherapy program. …

This study tested whether ketamine, a drug that blocks certain brain signals, can help people with tinnitus (ringing in the ears). 42 adults with chronic tinnitus received both ketamine and a placebo on different days. Researchers used brain scans to measure changes in brain chem…

This study tested whether osteopathic manual therapy—gentle hands-on techniques for muscles and joints—can reduce the discomfort and loudness of tinnitus in people whose symptoms change with movement. Fifty-four adults with tinnitus for at least six months received either real os…

This study tested whether playing specific sounds can temporarily reduce the loudness of tinnitus (ringing in the ears). Forty-five adults with chronic tinnitus listened to personalized sound clips for 3 minutes and 20 minutes. Researchers measured how much the tinnitus quieted d…

This pilot study tested a non-invasive white noise device called TinniSoothe in 20 UK veterans with persistent tinnitus. Participants wore the device around their neck during the day and docked it at night for at least one month. The goal was to see if it reduces tinnitus symptom…

This study looked at whether a cochlear implant in the poorer ear can help adults with hearing loss in one ear who already use a hearing aid in the better ear. Forty adults who had trouble with standard hearing aids received a cochlear implant. Researchers measured word understan…

This study looked at whether a cochlear implant in the deaf ear helps adults who have good hearing in one ear but severe hearing loss in the other. 59 adults received an implant and were tested on understanding speech in quiet and noise, locating sounds, and overall benefit. The …

This study tested a hearing care program for older adults with both hearing loss and dementia. Speech-language pathologists delivered the program at home. The goal was to see if better hearing could reduce troubling symptoms like agitation and improve quality of life. 77 people t…

This early study tested a new implant device for people with severe tinnitus (ringing in the ears). Nine adults received the implant to see if it was safe and could reduce their symptoms. The study measured side effects and used questionnaires to track changes in tinnitus severit…

This study looked at whether adjusting hearing aids helps older adults (60+) communicate more easily and with less mental tiredness. Sixty people with hearing loss who had never used hearing aids took part. Researchers measured listening effort, fatigue, and sentence recognition …

This study tested whether adding health and wellness coaching through a mobile app could help people with hearing loss get more satisfaction from their hearing aids. Thirty-four participants used the app to work with a health coach and track their progress. The goal was to see if…

This completed study tested whether manual therapy (hands-on treatment) on the neck can reduce tinnitus in people whose ringing ears are linked to neck pain. 31 adults with somatic tinnitus received either manual therapy or neck exercises. The goal was to see if treating the neck…

This study tested a device called SinuSonic that combines sound vibrations with gentle pressure to help people with Eustachian tube dysfunction (ETD) and facial pain. Thirty adults used the device twice a day for six weeks. Researchers measured changes in symptoms like ear pressu…

This study tested whether a smartphone app helps people with dizziness do their prescribed balance exercises more consistently. Thirty adults with various vestibular disorders were randomly assigned to use the app or keep a paper diary. The researchers measured how often particip…

This study tested whether injections of incobotulinum toxin A (similar to Botox) into muscles around the ear can relieve tinnitus, a persistent ringing in the ears. Forty-one adults with tinnitus for at least two months received either the drug or a placebo injection. The main go…

This study looked at whether a computer algorithm could improve how a cochlear implant is set for people who have one implant and a hearing aid in the other ear. Nine adults with severe hearing loss took part. The goal was to see if the new settings helped them hear better in qui…

This study tested whether combining mild electrical brain stimulation (tRNS) with white noise can temporarily reduce tinnitus symptoms. 35 adults with chronic tinnitus received either the combined treatment or brain stimulation alone. Researchers measured changes in tinnitus loud…

This study tested a new bimodal Bluetooth streaming feature for people who use a MED-EL cochlear implant in one ear and a Starkey hearing aid in the other. Ten participants tried the feature for one week and then completed a survey about their listening experience. The goal was t…

This study tested an herbal compound in 108 adults who had trouble sleeping and tinnitus (ringing in the ears) but did not want to take sleeping pills. Participants took either a low dose, high dose, or placebo daily for 3 months. Researchers measured changes in sleep quality and…

This study looked at two ear sprays—Ectoin Ear Spray and Normison Ear Spray—to see how well they work and if they are safe for people with chronic itching and skin irritation of the outer ear canal. 60 adults took part in this real-world observation. The main goal was to check if…

This study tested whether people with tinnitus can tell if they are receiving real or fake ultrasound stimulation of the vagus nerve in the ear. Twenty adults with constant tinnitus for at least six months took part. The goal was to see how well the blinding worked and what side …

This study tested a new way to adjust cochlear implants for people who are deaf in one ear but have some hearing in the other. Researchers used an evolutionary algorithm to customize the frequency settings of the implant. The goal was to help participants understand speech better…

This study tested a new, less invasive surgical method for placing a bone-anchored hearing device (Ponto implant) in 52 adults with hearing loss. The goal was to see if the implant stayed securely in place without causing skin problems or pain. The approach aims to make the proce…

This study looked at whether taking statins (cholesterol-lowering drugs) can reduce hearing loss caused by platinum-based chemotherapy in people with solid tumors. 56 adults who were about to start chemotherapy took part. The goal was to see if statins could protect their ears fr…

This study tested a new sound processor, the Osia 3, against the current Osia 2 model in 12 adults with hearing implants. Participants completed hearing tests and rated sound quality with both devices. The goal was to see if the new processor improves speech understanding in nois…

This study looked at whether placing small tubes in the ears of children aged 1-4 with chronic ear fluid (otitis media with effusion) improves their sleep and quality of life. Sixty children were randomly assigned to either receive ear tubes or not. Sleep was measured with a wris…

This study tested whether a new sound processor (Osia 3) helps adults with hearing loss or single-sided deafness hear better than the current model (Osia 2). Twenty-nine adults who already have a bone-anchored implant tried both processors. Researchers measured speech understandi…

This study tested whether a smartphone app could provide the same relief for chronic tinnitus as face-to-face counseling. 42 adults with constant ringing in their ears received either app-based or in-person counseling over six weeks. The goal was to see if the app could reduce th…

This study tested a 4-week virtual reality exercise program to help people who get motion sickness from visual cues, like in VR or certain videos. 46 adults, some with and some without motion sickness, took part. The program used 360-degree travel videos in a VR headset to gradua…

This study tested whether a new behind-the-ear audio processor (SONNET 3) is more satisfying for people who already use a cochlear implant. Twenty experienced users tried the new design and reported their satisfaction. The goal was to see if small design changes improve daily com…

This study tested a daily dietary supplement called ACEMg (Soundbites) in 64 adults with hearing loss or tinnitus. Participants took the supplement for 24 weeks and completed hearing tests and symptom surveys at home using a smartphone app. The goal was to see if the supplement c…

This study tested different doses of liposomal bupivacaine, a long-lasting numbing medicine, in 55 adults having shoulder surgery. The goal was to find the smallest dose that still blocks pain but lets patients move their arm. Researchers used a special method where each patient'…

This study tested whether repetitive transcranial magnetic stimulation (rTMS) can help people with chronic, severe tinnitus (ringing in the ears). Sixty-four adults received either real or fake rTMS at different intensities. The goal was to see if the treatment reduces tinnitus l…

This study tested whether hearing aids can improve thinking, daily behavior, and quality of life in people with mild to moderate Alzheimer's disease who also have age-related hearing loss. Fifty-one participants were split into two groups: one got real hearing aids for 12 months,…

This study tested whether changing the stimulation settings (called MAPs) in cochlear implants can improve how well adults with hearing loss understand speech, both in quiet and noisy environments. Twenty experienced cochlear implant users tried different low-power settings and e…

This completed study tested whether adding gastrodin acupoint injections to standard care helps people with sudden hearing loss and vertigo. One hundred adults received either standard therapy alone or standard therapy plus injections into specific acupuncture points over four we…

This study placed a humanoid robot in the homes of 10 children aged 8 to 12 who have cochlear implants. The robot can talk, listen, and interact via a touchscreen, aiming to make speech therapy practice more fun and accessible. The main goal was to see how often children would us…

This study tested a new sound processor (Sentio 1) for people with conductive or mixed hearing loss who already have a bone-anchored implant. Eleven adults participated, and the main goal was to see how much their hearing improved with the device. The results showed measurable he…

This study tested the ALICE app, a smartphone tool designed to train listening and communication skills in people with hearing loss. 161 adults who already use hearing aids or cochlear implants used the app alongside their usual care. The goal was to see if the app could improve …

This study tested whether an AI-powered chatbot could help people with chronic tinnitus (ringing in the ears). 172 adults used either the chatbot for daily therapy sessions or read educational materials for 30 days. The goal was to see if the chatbot could reduce tinnitus severit…

This study tested the RONDO 3, a new single-unit audio processor for people with cochlear implants. It includes features like beamforming and noise reduction to help users hear speech in noisy places. Twenty experienced users participated to see if these features improve hearing …

This study looked at whether placing a bone-anchored hearing implant in a single surgery is as safe as the traditional two-step approach in children aged 4 to 9. The single-stage method is already standard in adults, but many surgeons still use two surgeries for kids. The main qu…

This study tested a device that gently vibrates the left ear to stimulate the vagus nerve, aiming to reduce the bother of chronic tinnitus. Forty adults with moderate to severe tinnitus used either the active device or a sham (inactive) device during 8 weeks of online mindfulness…

This study tested a new device called Incremental Velocity Error (IVE) that uses a headband to help retrain the brain's balance system. It compared the device to standard eye and head exercises in 24 adults with dizziness from mild traumatic brain injury or inner-ear nerve damage…

This study tested a new way to process sound to help people with hearing loss understand speech better, especially tricky consonant sounds. Forty adults who use both a cochlear implant and a hearing aid (bimodal users) listened to consonants processed in different ways. The goal …

This study tested a program where parents learned special communication strategies to help their toddlers with hearing loss develop spoken language. 105 children aged 12-18 months with bilateral hearing loss and no other disabilities took part. Parents received coaching via video…

This study tested whether a web app can fit hearing aids as effectively as the standard method done by a professional. 28 adults with mild-to-moderate hearing loss tried both approaches. The goal was to see if the web app provides similar benefit in everyday listening situations.

This study tested whether using a virtual reality headset is as good as standard equipment for improving balance in people with vertigo. 76 adults with vestibular disorders completed a 3-4 week rehabilitation program. The goal was to see if the cheaper, smaller VR device could ma…

This pilot study tested a virtual reality system called DizzyVR for rehabilitating people with dizziness from inner ear disorders. Ten adults used the system for eight weekly sessions. The goal was to see if it was easy to use, safe, and enjoyable, and to gather early data on whe…

This completed Phase 1 study tested whether olanzapine, an antipsychotic drug, can reduce the discomfort of tinnitus (ringing in the ears). Fifty adults with stable tinnitus for at least 6 months received either olanzapine or a placebo in a crossover design. The main goal was to …

This study tested two online programs—cognitive behavioral therapy (CBT) and mindfulness—to help adults cope with the distress caused by tinnitus (ringing in the ears). 67 participants were randomly assigned to one of the two treatments or a waiting list. The goal was to see if t…

This study looked at 73 people with otosclerosis who had stapes surgery using bone cement to fix the middle ear bones. The goal was to see if bone cement helps improve hearing over the long term. Researchers measured both conductive and sensorineural hearing changes with hearing …

This study tested a robotic device called iotaSOFT that helps surgeons insert cochlear implants into the ears of children with hearing loss. Twenty children aged 9 months to 12 years took part. The goal was to see if the robot is safe and works well. Researchers tracked any probl…

This small study tested a single 6-hour intravenous infusion of brexanolone in 10 adults with tinnitus. The main goal was to check safety and tolerability, while also measuring changes in tinnitus loudness. Results are limited due to the small size and lack of a placebo group.

This study tested whether a special 40 Hz burst of sound can provide longer-lasting relief from tinnitus (ringing in the ears) compared to standard continuous sound therapy. Researchers enrolled 265 adults with chronic tinnitus and used EEG to measure brain activity changes. The …

This study tested whether a brief electrical stimulation of the inner ear could temporarily reduce tinnitus (ringing in the ears) in 25 adults with severe, disruptive tinnitus. Researchers aimed to find the best spot for stimulation to guide development of a future implantable de…

This study tested two drugs used to reverse muscle relaxants after surgery: sugammadex and a combination of neostigmine and glycopyrrolate. The goal was to see which one better prevents urinary retention in 124 patients having ear, nose, or throat surgery who were at high risk du…

This study tested whether a low dose of tranexamic acid, a drug that helps blood clot, could reduce bleeding during middle ear surgery. 100 adults undergoing microscopic or endoscopic ear surgery received either the drug or a placebo. The goal was to see if the drug improved the …

This study tested a new virtual reality rehab program for adults with two cochlear implants who struggle to locate where sounds come from. Twelve participants completed 8 sessions over a month, using head movements and joystick feedback to practice sound localization. The goal wa…

This completed study tested Nuance Audio glasses, which have a built-in hearing aid for adults with mild to moderate hearing trouble. 21 participants wore the glasses and took speech tests in quiet and noisy settings, plus a real-world walking tour. The goal was to see if the dev…

This completed study tested a hearing aid that is built into a pair of glasses for adults with mild to moderate hearing loss. The goal was to see if the device helps people understand speech better in noisy settings and reduces listening effort. Twenty-one adults participated in …

This study looked at 324 people with hearing loss and an inner ear problem called enlarged vestibular aqueducts. Researchers collected DNA, hearing tests, and scans to find genes that may cause the condition. The goal was to learn more about why it happens, not to test a treatmen…

This study tests an open-source speech-processing platform, called the Master Hearing Aid, as a wearable hearing aid for people with sensorineural hearing loss. Participants will wear the device in real-world settings and adjust it to their liking, then complete speech perception…

This study aims to find the genetic causes of hereditary hearing loss and balance disorders. Researchers will study families with these conditions, collecting medical history, blood or cheek swabs, hearing and balance tests, and sometimes scans. The goal is to identify genes and …

This study compared two imaging methods—PET/CT and labeled leukocyte scintigraphy—for monitoring malignant otitis externa, a serious infection of the ear canal that can spread to the skull. Researchers looked at 18 patients who had both scans before and after antibiotic treatment…

This study tested whether a computer model could find the best combination of active electrodes in a cochlear implant to improve speech understanding. Fourteen adults with cochlear implants tried different settings, including ones recommended by the model, and their speech recogn…

This study aimed to understand why people with cochlear implants vary in how well they understand speech. Researchers measured electrical interactions between the implant's electrodes in 17 adults with hearing loss. They compared these measurements to each person's ability to rec…

This study tested whether virtual reality (VR) training could help deaf and hard-of-hearing students learn vocational skills better than traditional methods. 48 students aged 17-20 with profound hearing loss participated in a 6-week program using 360-degree VR simulations of hote…

This study tested how well adults with hearing loss understand speech in noisy settings using hearing aids alone versus hearing aids paired with a remote microphone. Nineteen experienced hearing aid users participated. The goal was to compare different remote microphone systems t…

This study looked at whether giving doctors education and feedback, a special digital otoscope, or both could help them avoid prescribing antibiotics for ear infections that don't need them. Forty pediatric clinicians who often prescribed antibiotics for ear infections were split…

This study looked at 183 parents of children with hearing impairments to understand how their psychological resilience relates to their disaster preparedness. Parents completed surveys measuring their resilience and how ready they feel for disasters. The goal is to find ways to b…

This study tested two different methods for programming cochlear implants in 17 adults with hearing loss. The goal was to see if a new, faster fitting method works as well as the standard one for understanding speech in quiet and noisy settings. Results will help improve how impl…

This study looked at whether the muscle relaxant tizanidine affects the acoustic reflex, which is your ear's natural way of protecting itself from loud sounds. 48 adults who were already taking tizanidine had their hearing and reflex tested before and after one week of treatment.…

This completed study used PET scans to examine brain changes in 20 people with asymmetric hearing loss who received a cochlear implant. Participants performed hearing and voice perception tests while their brain activity was measured. The goal was to understand how the central au…

This study looked at how to improve care for dizzy patients in the emergency department. Over 90,000 adults participated. The goal was to help doctors use proven tests and treatments for common causes of dizziness like BPPV. The study tested new training and tools to make sure pa…

This study looked at how deaf children ages 18 to 60 months learn new words in American Sign Language (ASL). Researchers used eye-tracking and behavior tests to see if kids assume each object has only one sign (mutual exclusivity) or if bilingual deaf children expect two words—on…

This study looked at whether cochlear implants, which help restore hearing, can also improve thinking and memory in adults aged 65 and older with hearing loss. Researchers gave 37 participants a series of cognitive tests before surgery and again at 6 months, 12 months, and 5 year…

This completed study tested three different intensities of gentle neck movements designed to stimulate the vagus nerve in 128 healthy adults. Researchers measured changes in heart rate, balance, pain sensitivity, and digestion (via stool samples). The goal was to find the best 'd…

This study looked for hidden immune system problems in adults who get frequent or severe bacterial infections, like pneumonia or meningitis. Researchers screened 120 adults aged 18-65 to see how many had an undiagnosed primary immunodeficiency. The goal was to find out if these c…

This study looked back at medical records of 55 people who received a specific type of cochlear implant and also use an acoustic earhook. Researchers measured how well they understood words and sentences in quiet settings over the long term. The goal was to confirm how well the s…

This study tested a simple way for adult survivors of childhood cancer to get their hearing checked. Instead of going to a hospital, participants took a hearing test at a local hearing aid shop. The goal was to see if this approach could help more survivors find out if they have …

This study looked at whether hearing and vision loss are linked to delirium (sudden confusion) in older hospital patients. Over 1,500 participants answered screening questions and had their hearing and vision tested. In a smaller trial, researchers tested if posting communication…

This study tested a program designed to improve psychological hardiness (like resilience and commitment) in hard-of-hearing female students in Saudi Arabia. 25 students took part, with some receiving the program and others continuing their usual activities. The goal was to see if…

This study tested whether community health navigators who use American Sign Language (ASL) via videoconferencing could help deaf, deafblind, and hard-of-hearing adults complete recommended cancer screenings. The 184 participants were aged 45-80 and had early hearing loss. The nav…

This study tested a new way to program cochlear implants in 47 children aged 4 to 12. Instead of the standard method, doctors used CT scans to see exactly where the implant's electrodes sit inside the ear, then turned off any poorly placed ones. The goal was to see if this person…

This study looked at 52 adults with dizziness and balance problems from a one-sided inner ear disorder. Researchers measured how well people functioned before and after a standard balance therapy program. The goal was to see if things like dizziness severity or personal factors c…

This completed pilot study looked at 46 older adults with Alzheimer's disease to see if age-related hearing loss is linked to trouble finding words. Participants took a computer test to measure word-finding ability and answered a hearing questionnaire. The goal was to better unde…

This study looked at whether using feedback and spacing out practice sessions can help children aged 5 to 9 who are deaf or hard of hearing learn new words more efficiently. Thirteen children took part in word-learning exercises to see which methods worked best. The goal was to f…

This completed study enrolled 186 people with mild to moderate hearing loss to understand how damage to inner ear sensory cells and auditory neurons affects speech understanding, especially in noisy environments. Participants were fitted with hearing aids and tested on speech rec…

This study tested French versions of three hearing and quality-of-life questionnaires (PEACH, SSQ-C, SSQ-P) in 101 children and teens aged 1 to 17. The goal was to see if these tools are reliable and accurate for measuring hearing performance and quality of life in French-speakin…

This study looked at 98 adults with severe-to-profound hearing loss to see if they also have balance problems. Since the inner ear controls both hearing and balance, researchers used special tests to measure how well the balance system works. The goal was to understand if hearing…

This study tested whether using real-ear measurements (REM) to fit hearing aids leads to better outcomes than using the manufacturer's default settings. 101 first-time hearing aid users participated. Researchers measured hearing ability, satisfaction, and cost-effectiveness to se…

This completed study looked at 150 children with severe to profound hearing loss to find how many have a specific genetic form called DFNB9. Researchers collected medical and genetic data from routine care. The goal was to better understand this condition and pave the way for fut…

This study tested a new method for programming cochlear implants called Focused Multipolar Stimulation (FMS). Researchers compared two ways to set up the implant: one using objective measurements and another based on the user's feedback. The goal was to see which approach helps a…

This study tested a program to help doctors prescribe antibiotics more appropriately for common childhood infections like earaches, sore throats, and sinusitis. Over 1,000 doctors took part, receiving online training, personalized feedback on their prescribing habits, and support…

This completed study looked at electronic health records from over 3,300 adults with tinnitus across three hospitals in China. Researchers aimed to identify risk factors and develop models to predict different tinnitus subtypes. The goal is to improve diagnosis and personalized c…

This study checked whether hot air balloon pilots, who are exposed to burner noise and air pressure changes, have more hearing, eustachian tube, or balance problems than other adults. About 105 pilots and non-pilots took part in safe, non-invasive hearing and balance tests. The g…

This completed study looked at how the inner ear responds to sound during and after cochlear implant surgery in 88 participants. Researchers used a noninvasive test called electrocochleography to measure electrical activity in the cochlea. The goal was to see if these measurement…

This study tested a simple hearing screening for head and neck cancer survivors who had chemotherapy and radiation. 55 adults completed a hearing questionnaire and a quick hearing test. The goal was to see if the screening was practical and helpful for catching hearing problems e…

This study looked at how children with and without hearing loss use eye gaze and facial expressions to improve speechreading (lip-reading). Researchers tested 140 children aged 8–11 with cognitive and speechreading tasks, and some children with hearing loss trained using a specia…

This study tested a new mobile app feature that helps cochlear implant users measure how loud different sounds feel. Twenty adults with cochlear implants used the app at home and in the clinic. The goal was to see if the app could collect accurate loudness data, which could make …

This study looked at whether musical pitch training can improve music appreciation and hearing in people with cochlear implants. 120 teenage and adult implant users took part, with some receiving musical training and others visual training as a comparison. The goal was to underst…

This study looked at how much children with hearing loss and their caregivers understand about what caused the hearing loss. Researchers asked 156 participants to fill out questionnaires about the type and cause of their hearing loss and whether knowing the cause matters to them.…

This study looked at how deaf people who were born deaf process reading in their brains. Researchers used brain scans to compare deaf and hearing readers. The goal was to understand how the brain adapts to reading without ever hearing speech sounds. 60 adults who are deaf and hav…

This completed study surveyed 250 adults with vestibular disorders (like vertigo) across Belgium, France, and the US. Participants filled out questionnaires about dizziness, anxiety, and thinking problems, while doctors provided routine test results. The goal is to link symptoms …

This study looked at how children aged 8 to 17 with two cochlear implants locate sounds in three-dimensional space. Using virtual reality and motion tracking, researchers measured pointing accuracy and head movements during sound tasks. The goal was to better understand spatial h…

This study looked at how the brain processes sound in 43 deaf adults who have two cochlear implants. Researchers compared their brain activity to people with normal hearing using PET or EEG scans. The goal was to understand if the timing between activating the two implants affect…

This study aimed to better understand hearing loss by measuring electrical signals from the hearing nerve during brain surgery. Researchers studied 19 patients with normal hearing or hearing loss to see how nerve fibers respond to sound. The goal was to improve a computer model o…

This study looked at 49 adult cochlear implant users to see if electrical measurements from the inner ear can predict the best sound levels for each person. Researchers collected data during surgery and after months of implant use, then compared it to standard hearing tests. The …

This study looked at how the brain processes speech sounds in 25 people with language impairment or hearing loss. Researchers used e-learning games or hearing aids to see if these interventions change brain activity. The goal was to better understand the underlying problems and g…

This study tested new ways of stimulating the hearing nerve in 19 adults who already have a cochlear implant. The goal was to see if these new methods could improve how well they hear sounds and understand speech. Researchers adjusted the device settings and measured hearing perf…

This study tested whether French versions of two standard hearing aid benefit questionnaires (IOI-HA and COSI) are accurate and reliable. Researchers enrolled 100 adults with hearing loss who use hearing aids. The goal was to confirm these questionnaires work well in French, so c…

This study tested a home-based reading program called Sit Together and Read (STAR) in 15 preschoolers with hearing loss. Caregivers read with their child for 15 weeks using special techniques to teach print concepts and letter knowledge. The goal was to see if the program is feas…

This study tested a mobile app that lets adults with cochlear implants track their hearing difficulties in real-world situations, like noisy restaurants. The goal was to see if the app could collect useful data on how the implant performs outside the clinic. Fifty-one experienced…

This study looked at 119 children who had platinum-based chemotherapy for certain cancers. Researchers wanted to find out if certain genes make some kids more likely to develop hearing loss from the treatment. By analyzing DNA from saliva samples, they hope to identify high-risk …

This completed study looked at whether medications used for COVID-19 or the COVID-19 vaccine can harm hearing. Researchers compared hearing test results among 90 adults aged 18-35: those who had COVID-19 and took medications, those who had COVID-19 but took no medications, and a …

This study looked at whether a person's thinking skills affect how much they benefit from hearing aids. Researchers tested 32 first-time hearing aid users aged 45-80, adjusting features like frequency compression or noise reduction. The goal was to see if customizing settings bas…

This study looked at whether a single implant in the lower jaw to hold a denture can change hearing ability. Thirty adults aged 50-65 who had never worn dentures before were tested. Their hearing was measured before and after getting the denture, after implant surgery, and after …

This study followed 51 adults who received a wider bone-anchored hearing implant (BIA300) to see how well it stayed in place and worked after 10 years. Researchers measured implant stability and checked for any skin or tissue problems. The goal was to see if the wider design is a…

This study tested whether giving doctors automated reports on their antibiotic prescribing habits could improve how often they follow official guidelines. Researchers looked at over 26,000 patients with pneumonia, ear infections, or sore throat. They compared antibiotic use befor…

This study looked at whether it's possible and acceptable to screen for hearing loss in the emergency department (ED). Researchers worked with 133 veterans who had mild hearing trouble to see if using a hearing device helped them communicate with doctors and understand discharge …

This study looked at how two common seasickness drugs (scopolamine and meclizine) change inner ear balance tests in 54 healthy soldiers who get seasick. Researchers measured eye movements before and after taking the drugs to see if these tests could predict which drug works best …

This study looked at how COVID-19 infection relates to tinnitus (ringing in the ears). Researchers in Brazil followed 233 people who had COVID-19 between 2020 and 2024, comparing those who developed new tinnitus, those who had it before, and those without it. The goal was to unde…

This study from the University of Zurich looked at how people with different neurological conditions walk. Researchers measured walking patterns in 208 adults, including those with stroke, Parkinson's, multiple sclerosis, and spinal cord injury, as well as healthy volunteers. The…

This study looked at whether a person's working memory should influence how hearing aids are set. Researchers tested 42 adults with hearing loss in a lab, adjusting two features: directional microphones and compression. Participants listened to sentences in noise from different d…

This study tested a French version of a questionnaire that measures dizziness symptoms in children aged 7 to 17. Researchers asked 85 kids with and without balance issues to fill out the survey twice, two weeks apart. The goal was to see if the translated questionnaire is reliabl…

This study measured the hearing quality of life of 130 children aged 2 to 10 with hearing aids or cochlear implants. Parents filled out a questionnaire called PEACH to rate how well their child hears in quiet and noisy everyday situations. The goal was to understand how different…

This study examined 22 deaf infants under 10 months old to find factors linked to early signs of neurodevelopmental disorders like autism. Researchers filmed psychiatric consultations and used a special scoring system to assess the babies' interaction and movement skills. By comp…

This study followed 50 children who received cochlear implants, measuring their brain's electrical responses to sounds and comparing them with speech and language test results over three years. The goal was to see if certain brain wave patterns could predict how well a child deve…

This study looked at 20 people with long-term balance problems caused by inner-ear damage. Researchers wanted to see if fast, unconscious eye movements called 'covert saccades' help them see clearly when moving their head. Participants had their eye movements measured during quic…

This study looked at how different channels in a cochlear implant interact and affect a person's ability to understand speech in noisy settings. Researchers tested 28 adults—some with normal hearing and some with cochlear implants—using speech tests and sound masking measurements…

This study tested whether healthy volunteers with minimal training could collect their own blood using a finger prick during brief periods of weightlessness on parabolic flights. The goal was to see if the blood samples were good enough to measure caffeine levels. Thirty particip…

This completed study tested whether a virtual reality training program could improve the ability to locate sounds in people with hearing loss. 79 participants performed sound localization tasks with and without visual feedback. The goal was to see if training could reduce pointin…

This study looked at how cochlear implant microphones change as they age and get dirty, and whether different signal coding strategies can help. Researchers tested 81 people with hearing loss by having them listen to words in noise at various levels, before and after cleaning the…