Insulin gel mends ear drums faster in small trial

NCT ID NCT07535827

Completed Disease control Sponsor: Deraya University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial tested a special insulin gel applied directly to the ear drum after surgery to repair a long-standing hole. Fifty adults with dry ear drum perforations received either the insulin gel or a plain foam control. The insulin group showed significantly better healing at follow-ups up to two months. While promising, the study is small and early, so more research is needed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: insulin gel (applied directly to the ear drum)
What this could lead to: If confirmed in larger trials, this insulin gel could become a simple, low-cost way to help ear drum perforations heal faster after surgery.
What could go wrong: This was a very small, early-phase trial (50 people). The results need to be repeated in larger, longer studies before we know if it really works safely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic tubotympanic suppurative otitis media Insulin Resistance Tympanic Membrane Perforation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TYMPANIC MEMBRANE PERFORATION

Contacts and locations

Locations

Minia university hospital

Minya, Egypt

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