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Wet or dry? study tests best way to patch an eardrum

NCT ID NCT07595484

Disease control Sponsor: Shaikh Zayed Hospital, Lahore Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compared two ways of preparing a tissue graft (temporalis fascia) for repairing holes in the eardrum caused by chronic ear infections. 92 adults aged 18–60 received either a wet or dry graft during tympanoplasty surgery. Researchers checked hearing improvement and graft healing three months after surgery to see which method worked better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
temporalis fascia graft (dry or wet)
What this could lead to
If one method proves better, it could improve hearing and surgical success for people with chronic ear infections and eardrum holes.
What could go wrong
This is a small, single-center study with only 92 participants. Results may not apply to all patients, and long-term outcomes beyond 3 months are not reported.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

92 people

The number who actually took part.

Started

Sep 2025

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18 to 60 years. * Patients of either gender. * Patients diagnosed with chronic otitis media. * Patients with inactive mucosal disease, with no active ear discharge. * Patients with a large central perforation of the tympanic membrane. * Tympanic membrane perforation persisting for at least 6 weeks. * Patients with pure conductive hearing loss confirmed on pure-tone audiometry. Exclusion Criteria: * Patients with active otitis media, acute infection, or active ear discharge. * Patients with tympanosclerosis or ossicular necrosis affecting ossicular chain mobility. * Patients with a history of previous ear surgery that could affect tympanoplasty outcomes, such as ossiculoplasty or mastoidectomy, except prior myringotomy. * Patients with sensorineural hearing loss or mixed hearing loss. * Patients with conditions impairing wound healing or postoperative care compliance, including uncontrolled diabetes mellitus or immunodeficiency disorders. * Patients with confirmed Eustachian tube dysfunction. * Patients with active infection in the throat, nose, paranasal sinuses, or oral cavity. * Patients with bleeding disorders.

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Conditions

The condition(s) this trial relates to.

chronic otitis media Tympanic Membrane Perforation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic otitis media Tympanic membrane perforation

Contacts and locations

Locations

  • Shaikh Zayed Medical college/hospital, Lahore

    Lahore, Punjab Province, 54000, Pakistan

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