New Pig-Tissue patch shows promise for fixing eardrums

NCT ID NCT04635228

Completed Disease control Sponsor: Cook Research Incorporated Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested a special graft made from pig tissue to close holes in the eardrum. Researchers followed 87 patients for 3 months after the graft was placed to see how many had complete healing. The goal was to find out if this material works well for repairing eardrum perforations.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Biodesign Otologic Repair Graft (a porcine-derived material used as a patch for the eardrum)
What this could lead to: If successful, this graft could offer a reliable way to repair eardrum perforations, potentially improving hearing and reducing ear infections.
What could go wrong: This is a small, post-market study with no comparison group, so results may not apply to everyone. The graft is made from pig tissue, which could cause allergic reactions in sensitive individuals.

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Conditions

The condition(s) this trial relates to.

Tympanic Membrane Perforation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EARDRUM PERFORATION TYMPANIC MEMBRANE PERFORATION

Contacts and locations

Locations

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
Cincinnati Children's Hospital

Cincinnati, Ohio, 45229, United States
Gloucestershire Royal Hospital

Gloucester, GL 3NN, United Kingdom
IU Health

Indianapolis, Indiana, 46202, United States
University Hospitals-Cleveland

Cleveland, Ohio, 44106, United States

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