Can a botox shot silence tinnitus? small trial hints at possibility

NCT ID NCT05650645

Completed Symptom relief Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether injections of incobotulinum toxin A (similar to Botox) into muscles around the ear can relieve tinnitus, a persistent ringing in the ears. Forty-one adults with tinnitus for at least two months received either the drug or a placebo injection. The main goal was to see if the treatment improved scores on a standard tinnitus questionnaire.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: incobotulinum toxin A (Xeomin)
What this could lead to: If it works, this could point toward a new treatment option for people with persistent ringing in the ears.
What could go wrong: This is a small, early-stage trial with only 41 participants. The treatment may not reduce tinnitus symptoms more than a placebo, and there are risks like injection site reactions or muscle weakness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

tinnitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TINNITUS

Contacts and locations

Locations

University of Minnesota

Minneapolis, Minnesota, 55455, United States

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