Could a single infusion quiet the ringing? small trial tests brexanolone for tinnitus
NCT ID NCT05645432
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This small study tested a single 6-hour intravenous infusion of brexanolone in 10 adults with tinnitus. The main goal was to check safety and tolerability, while also measuring changes in tinnitus loudness. Results are limited due to the small size and lack of a placebo group.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
brexanolone (allopregnanolone)
What this could lead to
If it works, this could point toward a new treatment to reduce tinnitus loudness.
What could go wrong
This is a very small, early-phase trial with only 10 participants and no placebo group. Results may not apply to everyone, and the drug may not show meaningful benefit.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Sage Investigational Site
Atlanta, Georgia, 30331, United States
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Sage Investigational Site
Iowa City, Iowa, 52242, United States