Could a single infusion quiet the ringing? small trial tests brexanolone for tinnitus
NCT ID NCT05645432
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This small study tested a single 6-hour intravenous infusion of brexanolone in 10 adults with tinnitus. The main goal was to check safety and tolerability, while also measuring changes in tinnitus loudness. Results are limited due to the small size and lack of a placebo group.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- brexanolone (allopregnanolone)
- What this could lead to
- If it works, this could point toward a new treatment to reduce tinnitus loudness.
- What could go wrong
- This is a very small, early-phase trial with only 10 participants and no placebo group. Results may not apply to everyone, and the drug may not show meaningful benefit.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Sage Investigational Site
Atlanta, Georgia, 30331, United States
-
Sage Investigational Site
Iowa City, Iowa, 52242, United States
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Other studies related to the condition(s) this trial covers.
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