Can a pill save hearing during CF lung treatment?
NCT ID NCT02819856
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether SPI-1005, a drug containing ebselen, can prevent hearing loss in people with cystic fibrosis who are receiving IV tobramycin for a lung infection. About 40 participants will receive either a placebo or one of three doses of SPI-1005 for 21 days. Researchers will measure hearing, lung function, and side effects to see if the drug is safe and effective.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
SPI-1005 (ebselen)
What this could lead to
If it works, this could point toward a way to protect hearing in cystic fibrosis patients who need strong antibiotics.
What could go wrong
This is a small, early-phase trial with only 40 participants, so results may not apply to everyone. The drug may not prevent hearing loss or could have side effects.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States