Auditory system disorder

This phase 3 trial tests whether an experimental drug called KP-100IT, injected into the spinal fluid, can help people with severe acute spinal cord injuries regain function. Participants, aged 18 to 89 with a complete loss of motor and sensory function (AIS grade A), receive fiv…

This early-stage trial tests a new cell therapy called Rincell-1 for adults with certain types of hearing loss who are getting a cochlear implant. The study will compare the safety and early effectiveness of receiving the cell therapy plus the implant versus the implant alone. Ab…

This trial tests whether two self-assessment methods in a smartphone app can generate hearing aid settings that match those from a standard hearing test. Adults with perceived mild-to-moderate hearing loss will use the app to self-test their hearing and also undergo conventional …

This trial investigates whether antibiotics like amoxicillin or amoxicillin-clavulanate ease symptoms of ear infections (acute otitis media) in children aged 6 months to 3 years better than a placebo. Over 1,100 children are randomly assigned to one of three groups, and families …

This study looks at whether a wearable insulin patch pump, guided by a continuous glucose monitor, can better control high blood sugar caused by high-dose steroids in people with sudden hearing loss and diabetes or prediabetes. About 44 participants will be randomly assigned to e…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This study compares activating a cochlear implant on the day of surgery versus the usual two-week wait. About 100 adults receiving a cochlear implant will be randomly assigned to one of the two groups. Researchers will track how quickly the implant settings stabilize, hearing imp…

This early study tests a new surgical device called the Microtable® Stereotactic System for cochlear implants. The device uses a custom-made frame to guide a drill precisely to the inner ear, potentially making surgery faster, less painful, and better at preserving taste. The stu…

This study tests an oral drug called glycerol tributyrate in 24 adults with MELAS or LHON-Plus, two rare mitochondrial diseases that cause severe symptoms like strokes and vision loss. The trial is open-label (everyone gets the drug) and uses each person as their own control over…

This study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…

The ROOT study is testing a personalized nutrition program for pregnant women. Participants receive standard prenatal care plus customized diet and lifestyle plans based on their genes and nutrient levels. The goal is to see if this approach can lower the chances of preterm birth…

This study tests whether injecting steroids directly into the inner ear can improve hearing in people with sudden, severe hearing loss that hasn't responded to standard treatment. Researchers will compare this method to standard steroid injections behind the eardrum. The trial in…

This study will test three new types of cochlear implants in 66 adults with severe hearing loss. The goal is to see if the implants improve speech understanding and overall hearing quality. Participants will receive the implant as part of their normal care, and researchers will t…

This early-stage trial tests whether tiny particles from stem cells can help treat severe sudden hearing loss. Nine adults will receive injections into the ear alongside standard care. The study checks for safety and whether hearing improves compared to a common steroid treatment…

This study compares two types of cartilage grafts used to repair eardrum holes in adults. One graft is thin (0.5 mm) and the other is thick (1.8 mm). The goal is to see which one leads to better healing and hearing after six months. Thirty adults with long-standing eardrum perfor…

This phase 3 trial tests whether adding aspirin and folic acid to standard treatment can improve recovery from sudden sensorineural hearing loss. The idea is that these drugs may improve blood flow to the inner ear. The study will enroll 142 adults with recent hearing loss and tr…

This study tests a surgical procedure called endoscopic stapedotomy for people with otosclerosis, a condition that causes progressive hearing loss. Surgeons will use a tiny camera to place a small artificial device in the middle ear to improve sound transmission. The study will f…

This study tests whether virtual reality (VR) therapy works better than standard balance exercises for people with long-term dizziness. Researchers will enroll 40 adults aged 18-70 who have had dizziness for over 3 months due to inner ear problems. Participants will receive eithe…

This study tests a cream called terbinafine hydrochloride for treating fungal ear infections (otomycosis). About 50 adults with symptoms like itching, pain, and discharge will have the cream applied in the ear every two days for two weeks. The goal is to see if the cream clears b…

This study explores why some adults struggle to understand speech in noisy environments even when their standard hearing tests are normal. Researchers will use a battery of advanced hearing tests—including extended high-frequency audiometry, inner ear electrical responses, and br…

This pilot study tests a new imaging system that uses OCT and vibrometry to let doctors see the middle ear bones and measure how they move in response to sound. The study enrolls 500 adults with conductive or sensorineural hearing loss. The goal is to compare these detailed motio…

This study tests whether artificial intelligence (AI) can accurately help diagnose and triage patients with hearing loss and tinnitus, conditions affecting millions in the UK. Researchers will compare AI recommendations to those made by ear, nose, and throat doctors for 1,500 adu…

This study tests a new laser otoscope to see if it helps doctors find fluid behind the eardrum in children. About 150 kids already scheduled for ear tube surgery will get both a laser and a standard white-light ear exam. The results will be compared to what the surgeon finds duri…

This study tests a new prototype device that measures brain responses to speech sounds in infants. Researchers will compare brain responses between infants with normal hearing and those with hearing loss, both with and without hearing aids. The goal is to see if the device can ac…

This study tests whether a gamified training program for doctors, plus an AI tool that analyzes ear drum images, can improve the accuracy of diagnosing ear infections (otitis media). About 200 patients with ear symptoms will be seen by doctors who either received the training or …

This study tests whether a smartphone algorithm (Glimpse) can accurately diagnose ear infections in children aged 6 months to 6 years. Parents and doctors will take videos of the child's ear, and the AI's diagnosis will be compared to that of an ear specialist. The goal is to see…

This study tests a program to help farmworkers protect their hearing from loud machinery. About 200 farmworkers and supervisors will take part. The program includes a video, group talk, and hands-on earplug training. Researchers will measure noise exposure and survey participants…

This study tests a culturally tailored Talking Circles program to prevent noise-induced hearing loss in Native American adults. 400 tribal members will join group discussions and hearing tests over 12 months. The goal is to increase hearing protection use and knowledge through co…

This pilot study tests a short, culturally adapted training to help farmworkers use earplugs correctly and prevent hearing loss from loud noise. Fifteen farmworkers will receive the training and have their earplug fit measured before and after. The goal is to see if the training …

This study tests whether a steroid nasal spray can prevent fluid buildup in the middle ear, a common side effect of radiation therapy for nasopharyngeal cancer. About 168 adults who are about to start radiation will use either the spray or a placebo for 12 months. The goal is to …

This study compares two types of virtual reality (VR) during common ear, nose, and throat (ENT) procedures. One group will watch calming scenery, while the other plays an interactive puzzle game. Researchers want to see which better reduces pain and anxiety. The study will includ…

This trial tests whether chewing sugar-free gum for 20 minutes, alongside standard intravenous medication, can reduce dizziness and nausea in adults with a common inner-ear condition called posterior canal BPPV. Participants are randomly assigned to either chew gum or receive sta…

This trial tests whether hands-on manual therapy, tinnitus retraining therapy, or a combination of both can reduce the severity and daily impact of somatosensory tinnitus — a type of ringing in the ears that can be triggered by neck, jaw, or head movements. Sixty-five adults with…

This study tests whether a program delivered by trained older adult peers can help people aged 60 and over with hearing loss. Participants receive an over-the-counter hearing device fitted to their needs along with communication training. The goal is to see if this affordable, co…

This trial tests whether a web-based, game-like training program can strengthen the connection between the ears and the brain in older adults with mild-to-moderate hearing loss. Over 12 weeks, participants complete listening and thinking exercises designed to improve speech under…

This trial tests whether a structured aural rehabilitation program, called CSSAR, can improve hearing aid outcomes for new adult users aged 55 and older with mild-to-moderate hearing loss. Participants will either receive standard audiological care or standard care plus the CSSAR…

This study tests whether a mobile app that combines digital cognitive behavioral therapy (CBT) with personal mental health coaching can reduce anxiety in adults with hearing or mobility disabilities. Participants use either the active program or a sham version for 8 weeks, with f…

This study looks at whether a special noise-generator feature built into Sonova hearing aids can make tinnitus less annoying for people with hearing loss. About 170 adults with chronic tinnitus (lasting at least 6 months) who already use these hearing aids will rate their annoyan…

This study compares real acupuncture to a sham (fake) version in 226 adults with chronic tinnitus (ringing in the ears lasting at least 6 months). Participants receive 10 sessions over 5 weeks. The main goal is to see if real acupuncture reduces tinnitus-related handicap more tha…

This study tests a new hearing aid algorithm called SEDA-HA designed to help people with hearing loss understand speech better in noisy environments. Participants aged 16 and older with mild to severe bilateral sensorineural hearing loss will use a prototype hearing aid with the …

This study investigates whether wet cupping therapy can help adults with chronic subjective tinnitus (persistent ringing or buzzing in the ears). Participants aged 21 to 65 with tinnitus lasting over six months are randomly assigned to receive either wet cupping plus usual care o…

This study tests whether adjusting cochlear implant programming based on the health of the hearing nerve in different parts of the inner ear can help people understand speech better in noisy settings. Researchers will compare two experimental sound-processing strategies against e…

This study tests a personalized music program for people who wear hearing aids but are unhappy with how music sounds. Researchers will create a custom frequency profile for each participant and add it to their hearing aids as a dedicated music setting. The trial includes 66 adult…

This study compares sound therapy, cognitive behavioral therapy (CBT), and their combination to help people with chronic tinnitus (ringing in the ears). Sixty adults aged 18-65 with stable health will be randomly assigned to one of three groups for six weeks. The goal is to see w…

Many people with migraine also suffer from tinnitus, a persistent ringing in the ears. This trial will compare two types of migraine preventives—newer anti-CGRP drugs and older medications like antidepressants and blood pressure drugs—to see which better reduces tinnitus symptoms…

This study tests whether a cochlear implant placed just outside the inner ear, near the round window, can safely reduce severe tinnitus that has not responded to standard treatments. Six adults with long-term, high-impact tinnitus will receive the implant in a two-step procedure.…

This study tests whether manual acupuncture can reduce the burden of acute tinnitus compared to sham acupuncture or usual care. Researchers will enroll 180 adults with bothersome tinnitus lasting 2 weeks to 6 months. Participants receive 10 sessions over 4 weeks, and outcomes foc…

This study tests whether osteopathic manipulative treatment (OMT) — a gentle, hands-on therapy — can reduce the need for ear tube surgery in children with chronic or recurrent ear infections. Two hundred children aged 6 months to 7 years will receive either OMT or a placebo manua…

This study tests a coordinated rehab program for 74 veterans with head and neck cancer. The program combines standard swallowing therapy with proactive hearing and balance checks and a nurse assessment to find other rehab needs. The goal is to reduce stress and improve well-being…

This study tests a hearing rehabilitation program called Hear2Share for elderly people in nursing homes who have hearing loss. The program uses a simple hearing device and is run by nursing home staff. Researchers will measure how well participants can hear words and how often th…

This study tests how well a noise-reduction feature called ForwardFocus works in two different sound processors for adults with cochlear implants. 26 veterans and non-veterans will use each processor and take speech tests in background noise. The goal is to see if the newer proce…

This study tests whether Ai Chi, a slow, controlled water exercise program, can help people with long-term dizziness from inner ear problems. 38 adults will either do standard home exercises or add Ai Chi sessions in a pool over 4 weeks. Researchers will measure changes in balanc…

This study tests whether special eye and balance exercises can reduce dizziness, motion sickness, and improve quality of life in people with inner-ear balance problems. Thirty-two adults with motion sickness or vertigo will do either standard habituation exercises or a new optoki…

This study tests a conversational AI system called Fudan Tinnitus Doctor (FTD) for adults with chronic tinnitus. About 256 participants will use either the AI chatbot or a standard digital education program for 30 days. Researchers will measure changes in tinnitus severity, sleep…

This study tests whether a single one-hour educational session with an audiologist can help people with hyperacusis (extreme sensitivity to sound) feel more comfortable around everyday noises. Five participants will track their sound exposure and sensitivity for one month using a…

This study tests whether an AI-powered mobile app can help people with hearing loss monitor and adjust their hearing aids on their own. The goal is to reduce the need for clinic visits and improve hearing in real-world environments. The trial will involve 120 adults who are start…

This study tests a new wind noise canceller for hearing aids that aims to reduce bothersome wind sounds while keeping speech clear. About 25 adults with mild to moderate-severe hearing loss will compare the new canceller to an older version by listening to recordings and choosing…

This study tests whether acupuncture can reduce the severity of chronic tinnitus (ringing in the ears) in adults. Researchers will compare 72 tinnitus patients with healthy volunteers, and track changes in symptoms and brain activity after 10 acupuncture sessions. The goal is to …

This study tests whether injecting a small amount of lidocaine (a numbing medicine) around the ear and jaw can reduce tinnitus severity and related disability. Thirty adults with normal hearing and no other ear conditions will receive the injections and be followed for three mont…

This pilot study tests an online program for parents of children with hearing loss who have recently had cochlear implant surgery. The program combines education about implant care and communication strategies with Acceptance and Commitment Therapy (ACT) to help parents manage st…

This study tests whether combining physiotherapy, structured exercise, and psychological support can reduce the burden of chronic tinnitus (ringing in the ears) in 160 adults aged 18-70. Participants will be randomly assigned to either the 8-week multimodal program or a control g…

This study tests if a new treatment—mild nerve stimulation on the ear plus personalized music—can reduce the annoyance of chronic tinnitus (ringing in the ears) better than standard therapy. About 386 adults with bothersome tinnitus for at least 6 months will be randomly assigned…

This study tests whether rimegepant, a drug used for migraines, can quickly reduce dizziness from conditions like vestibular migraine. About 370 adults with moderate to severe dizziness will receive either rimegepant plus betahistine or betahistine alone. The main goal is to see …

This study tests whether umPEALUT, a supplement that reduces inflammation, can help people with tinnitus. The researchers believe that inflammation in the ear and brain may cause or worsen the phantom sounds. One hundred adults with tinnitus will receive either the supplement or …

This study compares two ways to insert a cochlear implant: using a robotic device or the standard manual method. Researchers want to see which approach leads to better hearing one year after surgery. The study will enroll 32 adults with hearing loss, randomly assigning them to on…

This study tests whether a 12-week mobile app therapy called Multimodal Acoustic Therapy (MAT) can improve how well children and teens with cochlear implants perceive music and enjoy it. Twenty-five participants aged 10 to 19 will use the app at home and be followed for another 1…

This study compares a nerve block (injecting numbing medicine near the ear) to standard painkillers (fentanyl and ketorolac) for children aged 6 months to 6 years having ear tube surgery. The goal is to see if the nerve block works just as well for pain control, with fewer side e…

This study compares two pain-relieving drugs, lidocaine and ketamine, given through an IV, to see if they can reduce stubborn face or mouth pain. About 105 adults with pain that hasn't responded to other treatments will receive one or both drugs. The goal is to measure pain relie…

This study tests whether automated text message reminders can encourage people with hearing loss to get hearing aids. Researchers will enroll 190 adults who have been recommended for hearing aids but do not yet use them. Participants will receive texts with basic information abou…

This study tests a new care pathway for adults getting a cochlear implant. Instead of the usual nine clinic visits in the first year, the new plan uses early activation of the implant and remote monitoring visits. The goal is to see if this approach is at least as good for hearin…

This study looks at how well new software helps clinicians adjust auditory implants for people with hearing loss. About 200 participants—including implant recipients and hearing healthcare professionals—will use the software in everyday clinic settings. The goal is to see how eas…

This study looks back at the medical records of 200 people who received a SONATA 2 cochlear implant. The goal is to understand how well the implant works over time in real-world settings, including speech recognition in quiet and noisy environments. Researchers will also analyze …

This study explores how the brain generates predictions when listening to natural sounds like speech and music. Researchers will use EEG to record brain activity while participants listen to audio and rate their pleasure and comprehension. The study includes people with normal he…

Standard hearing tests often fail in children with autism or social communication disorders because they struggle to engage with beeps and tones. This study tests whether using band-pass filtered familiar music — a child's known song altered to target specific frequencies — can p…

This trial is testing a device that has not been approved by the U.S. FDA. The purpose is to gather information about how the device works in people. Participants will be monitored for safety and any effects. The study is still ongoing, and details about who can join are not yet …

This observational study looks at whether children aged 3 months to 16 years are more likely to complete their full course of antibiotics when prescribed at a primary care clinic versus a hospital emergency department. Researchers surveyed parents by phone after treatment ended t…

This study surveys about 2,800 adults aged 65 and older in Xinxing County, China, to measure how many have untreated vision or hearing problems. Participants receive eye exams, hearing tests, and questionnaires. The goal is to provide local health services with data to improve ca…

This study tests a software tool called OTOGUIDE that helps surgeons monitor the placement of a cochlear implant electrode during surgery. Currently, surgeons lack real-time feedback on where the electrode is inside the cochlea, which can affect hearing outcomes. The trial will c…

This study investigates whether auditory and cognitive training can help adults with cochlear implants understand speech better. Researchers will enroll 100 experienced implant users and randomly assign them to different training programs. The goal is to see if these intervention…

This study will measure balance, coordination, and reaction time in 41 adults aged 18-40 who experience motion sickness. Participants will complete a series of physical tests and a controlled motion sickness provocation session. The goal is to see how these sensorimotor skills re…

This study follows 100 adults diagnosed with skull base osteomyelitis, a rare and serious bone infection near the ear and skull base. Researchers will track how often the infection returns or leads to death within 12 months. The goal is to gather real-world data to help standardi…

This study will follow 40 older adults (age 60+) with severe hearing loss who have or will receive a cochlear implant. Researchers want to see if the implant improves social interaction and thinking skills. Participants will fill out questionnaires, wear a small audio recorder fo…

This pilot study will test if parents can learn to use a digital otoscope (ear camera) at home to check for ear infections in their young children. About 40 children aged 1-4 who have had ear infections before will take part. Parents in the study group will get training and a dev…

This study aims to create a tool that predicts age-related hearing loss using artificial intelligence and blood samples. Researchers will analyze 15 years of data from 1,000 older adults and also test 100 seniors for proteins linked to memory problems. The goal is to identify ris…

This study will follow over 3,000 older adults for three years to see how age-related hearing loss is connected to dementia. Researchers will use hearing tests, cognitive assessments, and blood markers to build a 'Hearing Health Clock' and early screening tools. The goal is to be…

This study will compare four different non-surgical bone conduction hearing devices in 20 adults aged 18 to 84 with mixed or conductive hearing loss. The goal is to see which device provides the best hearing improvement by measuring hearing thresholds. The results could help guid…

This pilot study will test whether over-the-counter (OTC) hearing aids are practical and acceptable for older adults with mild-to-moderate hearing loss who are at risk for dementia. Forty participants aged 50 and older will either use the hearing aids right away or wait three mon…

This study surveys 600 health sciences students (excluding audiology majors) to see what they know and think about hearing loss and hearing aids. Participants fill out a 29-item questionnaire. The goal is to find gaps in knowledge so that education can be improved.

This study looks at how platinum-based chemotherapy can cause permanent hearing loss in cancer patients, and whether people from poorer backgrounds are more affected. Researchers will test hearing and thinking skills in 172 patients from North West England before and after treatm…

This study will test two methods for programming electric acoustic stimulation (EAS) in cochlear implant users who still have some natural hearing. One method uses electrical measurements from the inner ear, while the other uses standard hearing tests. The goal is to see which ap…

This study looks at 35 industrial workers who have hearing problems from loud noise at work. Researchers will test their balance and ask about daily activities to see if hearing loss affects how steady they feel. The goal is to understand if hearing issues are linked to balance t…

This study looks at how brain processes like attention and inhibition help people adapt after hearing loss. Researchers will use EEG to measure brain waves in 90 adults receiving cochlear implants, comparing them to normal-hearing participants. The goal is to find brain markers t…

This study investigates the connection between temporomandibular joint (TMJ) disorders and tinnitus (ringing in the ears). Researchers will use 3D jaw imaging and hearing tests in 50 adults to see if jaw bone shape and arthritis are linked to tinnitus. The goal is to better under…

This study looks at 10 adults over 50 with hearing loss and one weak balance ear. It compares implanting the device in the weak-balance ear versus the good-balance ear. The goal is to see if choosing the weaker side helps reduce dizziness after surgery.

This study tests a new digital health tool designed to help adults aged 40 and older who have two or more long-term health conditions, like high blood pressure, diabetes, or depression. The tool includes an electronic system to guide doctors, telemedicine for specialist visits, a…

This study looks at whether objective measurements, like the stapedius reflex, can help doctors program cochlear implants more precisely. Currently, tuning relies on patients describing what they hear, which can be subjective. Researchers will test 60 adults with severe hearing l…

This study will test whether a specially designed card game can improve knowledge and health beliefs about HPV in hearing-impaired adults. Forty participants will be randomly assigned to play the card game or receive standard education. The goal is to see if this fun, visual meth…

This study will observe 100 adults who receive the Sentio bone conduction hearing system as part of their normal care. The device is implanted under the skin and sends sound vibrations through the skull to the inner ear. Researchers will track how often the device is used success…