Can a spinal injection restore movement after paralysis?
NCT ID NCT07722962
First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether an experimental drug called KP-100IT, injected into the spinal fluid, can help people with severe acute spinal cord injuries regain function. Participants, aged 18 to 89 with a complete loss of motor and sensory function (AIS grade A), receive five weekly doses and are followed for 24 weeks. The study measures improvements in spinal injury classification, motor and sensory scores, and the ability to perform daily activities.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- an experimental drug called KP-100IT injected into the spinal fluid
- What this could lead to
- If it works, this could point toward a treatment that helps people with severe spinal cord injuries recover significant movement and sensation.
- What could go wrong
- This is a small, early-phase trial with only 10 participants, so results may not apply widely. The drug is injected directly into the spine, which carries risks like infection or nerve damage.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Japan Organization for Occupational Health and Safety Comprehensive Spinal Cord Injuries Center
Iizuka, Fukuoka, 820-8508, Japan
Contact Phone: •••-•••-••••
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Japan Organization for Occupational Health and Safety Hokkaido Spinal Cord Injury Center
Bibai, Hokkaido, 072-0015, Japan
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National Hospital Organization Murayama Medical Center
Musashimurayama, Tokyo, 208-0011, Japan
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