Can a supplement stop the ringing? new trial targets brain inflammation in tinnitus

NCT ID NCT06718452

Not yet recruiting Symptom relief Sponsor: University of Campania Luigi Vanvitelli Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether umPEALUT, a supplement that reduces inflammation, can help people with tinnitus. The researchers believe that inflammation in the ear and brain may cause or worsen the phantom sounds. One hundred adults with tinnitus will receive either the supplement or a placebo for a period, and their symptoms will be tracked using questionnaires and hearing tests.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: umPEALUT (palmitoylethanolamide and luteolin) with or without rutin and 5-HTP
What this could lead to: If it works, this could point toward a new way to ease tinnitus by targeting inflammation in the brain and ear.
What could go wrong: This is an early, small trial with no phase designation. The supplement is not a proven treatment, and results may not apply to all tinnitus patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Neuroinflammatory Diseases neuronitis tinnitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEUROINFLAMMATION TINNITUS

Contacts and locations

Locations

Vanvitelli ENT department

Naples, Campania, 80138, Italy

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