Antipsychotic drug could quiet ringing ears
NCT ID NCT07190482
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This completed Phase 1 study tested whether olanzapine, an antipsychotic drug, can reduce the discomfort of tinnitus (ringing in the ears). Fifty adults with stable tinnitus for at least 6 months received either olanzapine or a placebo in a crossover design. The main goal was to see if olanzapine lowers tinnitus-related distress, measured by a standard questionnaire.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Olanzapine (Zyprexa) 5 mg oral tablet
- What this could lead to
- If it works, this could point toward a new way to reduce the distress of tinnitus for some people.
- What could go wrong
- This is a very early Phase 1 trial with only 50 participants. Olanzapine is an antipsychotic with side effects, and it may not work better than a placebo for tinnitus.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Research Ethics Committee (CEP)
São Paulo, São Paulo, 05403000, Brazil
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Other studies related to the condition(s) this trial covers.
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