Antipsychotic drug could quiet ringing ears
NCT ID NCT07190482
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This completed Phase 1 study tested whether olanzapine, an antipsychotic drug, can reduce the discomfort of tinnitus (ringing in the ears). Fifty adults with stable tinnitus for at least 6 months received either olanzapine or a placebo in a crossover design. The main goal was to see if olanzapine lowers tinnitus-related distress, measured by a standard questionnaire.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Olanzapine (Zyprexa) 5 mg oral tablet
What this could lead to
If it works, this could point toward a new way to reduce the distress of tinnitus for some people.
What could go wrong
This is a very early Phase 1 trial with only 50 participants. Olanzapine is an antipsychotic with side effects, and it may not work better than a placebo for tinnitus.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Research Ethics Committee (CEP)
São Paulo, São Paulo, 05403000, Brazil