New vaccine shows promise against childhood ear infections

NCT ID NCT04193215

Completed ⭐️ VACCINE ⭐️ Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new vaccine called V114 in over 7,000 healthy infants to see if it could prevent ear infections caused by certain pneumococcal bacteria. The vaccine was given alongside routine childhood shots. Researchers tracked how many babies got vaccine-type ear infections and monitored for serious side effects. The goal was to see if V114 works better than no V114 at preventing these infections.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: V114 (Pneumococcal 15-Valent Conjugate Vaccine)
What this could lead to: If successful, this vaccine could reduce the number of ear infections caused by certain pneumococcal bacteria in young children.
What could go wrong: This is a completed phase 3 trial, but results may not apply to all children or regions. Ear infections can still be caused by other germs not covered by the vaccine.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

otitis media infectious otitis media prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE OTITIS MEDIA (AOM)

Contacts and locations

Locations

Bamrasnaradura Infectious Disease Institute ( Site 0011)

Nonthaburi, 11000, Thailand
Bhumibol Adulyadej Hospital ( Site 0013)

Sai Mai, Bangkok, 10220, Thailand
Chiang Rai Prachanuchro Hospital-Pediatrics ( Site 0015)

Chiang Rai, 57000, Thailand
Chulalongkorn University ( Site 0008)

Bangkok, Bangkok, 10330, Thailand
Faculty of Medicine Thammasat Univ. ( Site 0007)

Khong Luang, Changwat Pathum Thani, 12120, Thailand
Maharaj Nakorn Chiang Mai Hospital ( Site 0001)

Chiang Mai, 50200, Thailand
Panyananthaphikkhu Chonprathan Medical Center ( Site 0014)

Pak Kret, Changwat Nonthaburi, 11120, Thailand
Phramongkutklao Hospital ( Site 0003)

Bangkok, Bangkok, 10400, Thailand
Prince of Songkla University Faculty of Medicine ( Site 0005)

Hat Yai, Changwat Songkhla, 90110, Thailand
Ramathibodi Hospital, Mahidol University ( Site 0009)

Rajthevee, Bangkok, 10400, Thailand
Sappasit Prasong Hosptial-Pediatric ( Site 0016)

Ubon Ratchathani, 34000, Thailand
Siriraj Hospital ( Site 0004)

Bangkok, Bangkok, 10700, Thailand
Srinagarind Hospital ( Site 0002)

Khon Kaen, 40002, Thailand

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