Can a simple anesthesia tweak stop Post-Surgery nausea?
NCT ID NCT05759481
First seen Aug 14, 2026 · Last updated Aug 14, 2026
Summary
This trial tests whether adding a low-dose propofol infusion during general anesthesia can prevent post-operative nausea and vomiting (PONV) in adults with a history of PONV or motion sickness. Participants receive either a hybrid approach (propofol plus sevoflurane) or propofol alone for total intravenous anesthesia. The study tracks nausea, retching, or vomiting within 24 hours after surgery to see if the propofol infusion helps.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- A low-dose propofol infusion added to standard anesthesia, or propofol used alone for total intravenous anesthesia.
- What this could lead to
- If effective, this could offer a simple way to reduce post-operative nausea and vomiting in people prone to it, improving recovery comfort.
- What could go wrong
- This is a small phase 2 trial, so results may not be definitive. Propofol can cause side effects like low blood pressure or breathing issues, and the added infusion may not significantly reduce nausea.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Penn State Health Milton S Hershey Medical Center
Hershey, Pennsylvania, 17033, United States
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