Gene therapy aims to restore hearing in children born deaf

NCT ID NCT05788536

Recruiting now ⭐️ CURE ⭐️ Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 4 times

Summary

This study tests a new gene therapy called DB-OTO for children with hearing loss caused by changes in the otoferlin gene. The treatment is injected into the inner ear to help restore hearing. Up to 30 children and infants will take part to check safety and how well it works.

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Conditions

The condition(s) this trial relates to.

auditory neuropathy autosomal recessive nonsyndromic hearing loss 9 Deafness, Autosomal Recessive 9 hearing disorder hearing loss disorder Hearing Loss, Sensorineural

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONGENITAL HEARING LOSS SECONDARY TO BIALLELIC MUTATIONS OF THE OTOFERLIN GENE (OTOF)

Contacts and locations

Locations

Addenbrooke's Hospital, Cambridge University Hospitals NHS FT
RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Boston Children's Hospital - Main
RECRUITING

Boston, Massachusetts, 02115, United States
Cincinnati Children's Hospital Medical Center
RECRUITING

Cincinnati, Ohio, 45229, United States
Clinica Universidad de Navarra- Pamplona
RECRUITING

Pamplona, Navarre, 31008, Spain
Columbia University Irving Medical Center
RECRUITING

New York, New York, 10032, United States
Great Ormond Street Hospital For Children NHS Foundation Trust
RECRUITING

London, WC1N 3JH, United Kingdom
Hospital Sant Joan de Deu
RECRUITING

Barcelona, 08950, Spain
Hospital Universitario Materno Infantil en las Palmas de Gran Canaria
WITHDRAWN

Las Palmas de Gran Canaria, 35016, Spain
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Nemours Children s Clinic
RECRUITING

Jacksonville, Florida, 32207, United States
Nemours Childrens Hospital
RECRUITING

Orlando, Florida, 32827, United States
Rady Children's Hospital
RECRUITING

San Diego, California, 92123, United States
Ramon y Cajal University Hospital
RECRUITING

Madrid, 28034, Spain
Seattle Children's Hospital
RECRUITING

Seattle, Washington, 98105, United States
Shinshu University Hospital
RECRUITING

Matsumoto-shi, Nagano, 390-8621, Japan
University Hospital Tubingen
RECRUITING

Tübingen, 72076, Germany
University of California Los Angeles Medical Center
RECRUITING

Los Angeles, California, 90024, United States