Can a simple injection save your hearing during cancer treatment?

NCT ID NCT07218913

Recruiting now Symptom relief Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests whether adding Pedmark to standard cisplatin chemotherapy can prevent hearing loss in men with metastatic testicular cancer. About 80% of patients currently develop hearing damage from cisplatin. Pedmark works by neutralizing harmful molecules that cause ear damage. The study will compare hearing outcomes between men who get Pedmark plus chemo and those who get chemo alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pedmark (sodium thiosulfate)
What this could lead to: If it works, this could point toward a way to prevent hearing loss in adults receiving cisplatin chemotherapy for testicular cancer.
What could go wrong: This is a very early Phase 1 trial with only 44 participants, so results may not be conclusive. Pedmark is already approved for children, but its effectiveness in adults is still uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hearing loss disorder malignant germ cell tumor malignant testicular germ cell tumor nongerminomatous germ cell tumor seminoma testicular cancer testicular non-seminomatous germ cell cancer testicular non-seminomatous germ cell tumor testicular seminoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEARING LOSS METASTATIC MALIGNANT GERM CELL TUMOR METASTATIC MALIGNANT NONGERMINOMATOUS GERM CELL TUMOR METASTATIC MALIGNANT TESTICULAR NON-SEMINOMATOUS GERM CELL TUMOR METASTATIC TESTICULAR SEMINOMA STAGE II TESTICULAR CANCER AJCC V8 STAGE III TESTICULAR CANCER AJCC V8

Contacts and locations

Locations

City of Hope Medical Center
RECRUITING

Duarte, California, 91010, United States

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