One-shot gene therapy aims to shrink ear tumors without surgery

NCT ID NCT06517888

Recruiting now Disease control Sponsor: Akouos, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests a gene therapy given as a single injection into the inner ear for people with a non-cancerous tumor called vestibular schwannoma. The therapy uses a harmless virus to deliver a gene that blocks blood vessel growth to the tumor, potentially stopping it from growing or shrinking it. The study will check safety and how well the delivery device works in 27 adults with hearing loss in the affected ear.

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Conditions

The condition(s) this trial relates to.

acoustic neuroma hearing loss disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

VESTIBULAR SCHWANNOMA

Contacts and locations

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Locations

Johns Hopkins Hospital
RECRUITING

Baltimore, Maryland, 21205, United States

Contact Email: •••••@•••••
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
University of Texas Southwestern
RECRUITING

Dallas, Texas, 75390, United States

Contact Email: •••••@•••••
Vanderbilt Bill Wilkerson Center
RECRUITING

Nashville, Tennessee, 37232, United States

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