Gene therapy vs. cochlear implants: which restores hearing better?

NCT ID NCT06237790

Recruiting now Knowledge-focused Sponsor: Eye & ENT Hospital of Fudan University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study compares how well people with a genetic form of deafness (DFNB9) can hear and understand speech after receiving gene therapy versus a cochlear implant. Researchers will also include healthy participants for comparison. The goal is to see if gene therapy can match or outperform cochlear implants, helping doctors create better rehabilitation plans.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: gene therapy
What this could lead to: If successful, this study could show that gene therapy restores hearing as well as or better than cochlear implants, pointing toward a future treatment for certain genetic deafness.
What could go wrong: This is an observational comparison, not a randomized trial, so results may be influenced by differences between groups. Gene therapy is still experimental and may not work for all types of hearing loss.

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Conditions

The condition(s) this trial relates to.

hearing loss disorder hereditary disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GENETIC DISEASE HEARING LOSS SPEECH PERCEPTION

Contacts and locations

Locations

Eye & ENT Hospital of Fudan University
RECRUITING

Shanghai, Shanghai Municipality, 200031, China
Peking Union Medical College Hospital
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100730, China
The First Affiliated Hospital of Nanchang University
NOT_YET_RECRUITING

Nanchang, Jiangxi, 330006, China
The First Affiliated Hospital of Zhengzhou University
NOT_YET_RECRUITING

Zhengzhou, Henan, 450052, China
The Second Xiangya Hospital of Central South University
NOT_YET_RECRUITING

Changsha, Hunan, 410011, China
West China Hospital, Sichuan University
NOT_YET_RECRUITING

Chengdu, Sichuan, 610041, China

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