New TB drug cocktail aims to shorten treatment

NCT ID NCT05807399

Recruiting now Disease control Sponsor: Michael Hoelscher Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This clinical trial is testing new combinations of tuberculosis (TB) drugs to see if they work better than the standard treatment. The study involves 390 adults with newly diagnosed, drug-sensitive TB. Researchers are comparing different drug regimens, including a new drug called BTZ-043, to find a shorter and more effective way to cure TB.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Combination of anti-tuberculosis drugs including BTZ-043, high-dose rifampicin, isoniazid, pyrazinamide, and moxifloxacin
What this could lead to: If successful, this could lead to shorter and more effective treatment regimens for drug-sensitive tuberculosis, reducing treatment duration and improving cure rates.
What could go wrong: This is an early-phase trial with only 390 participants, so results may not apply to all TB patients. The new drug BTZ-043 is still experimental, and side effects or lack of efficacy are possible.

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Conditions

The condition(s) this trial relates to.

pulmonary tuberculosis tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OTHER SPECIFIED PULMONARY TUBERCULOSIS PULMONARY TUBERCULOSIS

Contacts and locations

Locations

Centre de Recherches Médicales de Lambaréné (CERMEL)
COMPLETED

Lambaréné, Gabon
Ifakara Health Institute (IHI)
RECRUITING

Bagamoyo, Tanzania
Instituto Nacional de Saúde (INS)
RECRUITING

Maputo, Mozambique
Isango Lethemba TB Research Unit. Clinical HIV Research Unit (CHRU), Wits Health Consortium.
NOT_YET_RECRUITING

Port Elizabeth, Eastern Cape, 6003, South Africa
Kamuzu College of Health Sciences (formerly College of Medicine)
RECRUITING

Blantyre, Malawi
Kilimanjaro Clinical Research Institute (KCRI)
RECRUITING

Moshi, Tanzania
Makerere University Lung Institute Limited
RECRUITING

Kampala, Uganda
National Institute for Medical Research (NIMR-MMRC)
RECRUITING

Mbeya, Mbeya, Tanzania
TASK Applied Sciences Clinical Research Centre
RECRUITING

Cape Town, 7500, South Africa
University of Cape Town Lung Institute
NOT_YET_RECRUITING

Cape Town, 7700, South Africa

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