Extensively drug-resistant tuberculosis
MONDO:0100482A type of drug-resistant tuberculosis that is resistant to any fluoroquinolone, and at least one of three second-line injectable drugs (capreomycin, kanamycin, and amikacin), in addition to resistance to rifampicin and isoniazid.
Also known as: XDR-TB
11 clinical trials for this condition and its sub-types.
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New hope for kids with Drug-Resistant TB: bedaquiline trial launches
Disease control Recruiting nowThis study tests a drug called bedaquiline in children and teens (0 months to under 18 years) with multidrug-resistant tuberculosis (MDR-TB), a lung infection that does not respond to standard antibiotics. About 60 participants will receive bedaquiline along with other TB medicat…
Phase: PHASE2 • Sponsor: Janssen Research & Development, LLC • Aim: Disease control
Last updated Jul 08, 2026 00:00 UTC
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TB study aims to unlock secrets of the disease
Knowledge-focused Recruiting nowThis study follows 150 people with active or latent tuberculosis (TB) to collect blood, sputum, and tissue samples. The goal is to better understand how TB behaves in the body and how the immune system responds. Participants receive standard TB treatment as part of the study, but…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Aug 18, 2026 02:00 UTC
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Blood test could revolutionize TB treatment monitoring
Knowledge-focused Recruiting nowThis study explores whether measuring tiny DNA fragments from the TB bacteria in the blood can help doctors monitor how well treatment is working. Researchers will enroll 140 adults with newly diagnosed TB in Thailand, taking blood samples over time to see if the DNA levels drop …
Sponsor: University of Oxford • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC