Extensively drug-resistant tuberculosis
MONDO:0100482A type of drug-resistant tuberculosis that is resistant to any fluoroquinolone, and at least one of three second-line injectable drugs (capreomycin, kanamycin, and amikacin), in addition to resistance to rifampicin and isoniazid.
Also known as: XDR-TB
11 clinical trials for this condition and its sub-types.
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Could a lower dose of an old antibiotic tame Drug-Resistant TB?
Disease control CompletedThis study tests whether a low daily dose of the antibiotic linezolid, added to a personalized combination of other drugs, is safe and tolerable for people with multidrug-resistant tuberculosis (MDR-TB). Participants take either linezolid or a placebo for 16 weeks, alongside thei…
Phase: PHASE1, PHASE2 • Sponsor: Centers for Disease Control and Prevention • Aim: Disease control
Last updated Jul 08, 2026 00:00 UTC
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New drug cocktail shows promise against Drug-Resistant TB
Disease control CompletedThis study tested a combination of three drugs—bedaquiline, pretomanid, and linezolid—in 109 people with extensively drug-resistant TB (XDR-TB) or multi-drug resistant TB (MDR-TB) that didn't respond to other treatments. Participants took the drugs for 6 to 9 months. The goal was…
Phase: PHASE3 • Sponsor: Global Alliance for TB Drug Development • Aim: Disease control
Last updated Jun 26, 2026 14:29 UTC
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Hotspot vs clinic: which TB hunt saves more lives?
Knowledge-focused CompletedThis study compares two strategies for finding undiagnosed tuberculosis (TB) in peri-urban Uganda. One strategy sets up screening at a large health clinic, while the other sends mobile screening teams into local hotspots where TB is thought to be most common. Researchers will tra…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Aug 14, 2026 00:00 UTC